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Merck

S8809

Sigma-Aldrich

Pan单克隆抗 钠通道 小鼠抗

~1 mg/mL, clone K58/35, purified immunoglobulin

别名:

Sodium Channel Antibody

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

K58/35, monoclonal

物種活性

mammals

濃度

~1 mg/mL

技術

immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons
western blot: 1 μg/mL using crude brain membrane prep (rat)

同型

IgG1

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

一般說明

电压门控钠通道/VGSCs(Nav)是由膜的去极化启动的跨膜蛋白。它们是具有大的成孔 α-亚基和小的 β-亚基的异质多聚体。

特異性

该克隆识别的序列在所有已知脊椎动物的 Na + 通道中是相同的。在培养的海马神经元中,该抗体可特异性染色轴突起始段。在坐骨神经和视神经中,它可染色郎飞结。

免疫原

来自细胞内 III-IV Na + 通道环的合成肽 CTEEQKKYYNAMKKLGSKK

應用

小鼠单克隆抗钠通道泛抗体可用于:
  • 免疫组化(1:50)
  • 免疫染色(1:200)
  • 免疫荧光
  • 免疫细胞化学(1:100)

生化/生理作用

电压门控钠通道/VGSCs(Nav)参与伤害性传导。它们在调节胞外和胞内空间之间的交换方面发挥着关键作用。VGSC 对于动作电位的启动和激发至关重要。它们参与神经元的兴奋性。因此,VGSC 基因的突变会导致几种癫痫疾病。

外觀

溶液含 10 mM Tris (pH 7.5)、 0.1 mNaCl、30% 甘油和 15 mM 叠氮化钠。

法律資訊

由SUNY Stony Brook 独家授权销售。

免責聲明

除非我们的产品目录或产品随附的其他公司文件中另有说明,否则我们的产品仅用于研究用途,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。

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Amanda L York et al.
eNeuro, 4(4) (2017-08-12)
The neuromuscular junction (NMJ) is a chemical synapse formed between motoneurons and skeletal muscle fibers. The vertebrate NMJ uses acetylcholine (ACh) as the neurotransmitter and features numerous invaginations of the postsynaptic muscle membrane termed junctional folds. ACh receptors (AChRs) are
J-C Platel et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(52), 19174-19179 (2005-12-17)
Before synaptogenesis, early excitability implicating voltage-dependent and transmitter-activated channels is known to be crucial for neuronal development. We previously showed that preplate (PP) neurons of the mouse neocortex express functional Na(+) channels as early as embryonic day 12. In this
Alexander Drobyshevsky et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(25), 5988-5997 (2005-06-25)
Disruption of oligodendrocyte lineage progression is implicated in the white-matter injury that occurs in cerebral palsy. We have previously published a model in rabbits consistent with cerebral palsy. Little is known of normal white-matter development in perinatal rabbits. Using a
Marie K Bosch et al.
Channels (Austin, Tex.), 10(4), 297-312 (2016-02-19)
Intracellular Fibroblast Growth Factor 14 (iFGF14) and the other intracellular FGFs (iFGF11-13) regulate the properties and densities of voltage-gated neuronal and cardiac Na(+) (Nav) channels. Recent studies have demonstrated that the iFGFs can also regulate native voltage-gated Ca(2+) (Cav) channels.
Analgesic and antipyretic natural products
Shilpi JA and Uddin SJ
Annual Reports in Medicinal Chemistry, 55, 435-458 (2020)

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