Merck

SAB4200176

Sigma-Aldrich

Anti-JNK antibody, Mouse monoclonal

clone 1C2, purified from hybridoma cell culture

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别名:
Anti-JNK-46, Anti-JNK1, Anti-JNK1A2, Anti-JNK21B1/2, Anti-JUN N-terminal kinase, Anti-MAP kinase 8, Anti-MAPK8, Anti-PRKM8, Anti-SAPK1, Anti-stress-activated protein kinase 1
MDL编号:
NACRES:
NA.44

生物来源

mouse

偶联物

unconjugated

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

1C2, monoclonal

分子量

antigen ~43 kDa

种属反应性

mouse, rat, human

浓度

~1.0 mg/mL

技术

western blot: 1-2 μg/mL using using whole extracts of mouse NIH-3T3 cells

同位素/亚型

IgG2a

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... MAPK8(5599)
mouse ... Mapk8(26419)
rat ... Mapk8(116554)

相关类别

一般描述

Anti-JNK antibody, Mouse monoclonal, (mouse IgG2a isotype) is derived from the hybridoma 1C2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant protein. JNK1 (c-Jun N-terminal kinase), also known as MAPK8 (mitogen-activated protein kinase 8) is a member of the MAP kinase family. This gene is mapped to human chromosome 10q11.

应用

Anti-JNK antibody, Mouse monoclonal has been used in immunoblotting and enzyme linked immunosorbent assay (ELISA).

生化/生理作用

JNK1 (or MAPK8) is a serine threonine kinase that is a key regulator of cellular apoptosis. During the lack of NFkB stiμLation; persistent activation of JNK1 results in TNF-a induced cell death. However, JNK1 may also function as an apoptotic inhibitor. For instance; JNK1 interacts with WOX1 to inhibit apoptosis. Furthermore, JNK1 phosphorylates Bcl-2 to mediate starvation-induced autophagy, and also activates SIRT1 by phosphorylation during conditions of oxidative stress. JNK1 is activated by UV irradiation and oncoproteins and hence may be implicated in cancer propagation
Monoclonal Anti-JNK antibody is specific for human, mouse and rat JNK1 (43 kDa) and/or JNK2 (55 kDa).
JNK1 is also involved in UV (ultra violet) radiation induced apoptosis, which is thought to be related to cytochrome C-mediated cell death pathway.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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The Role of c-Jun N-Terminal Kinase (JNK) in Retinal Degeneration and Vision Loss
Kim BJ, et al.
Advances in Experimental Medicine and Biology, Adv(Exp), Med-Med (2018)
HSP70 Facilitates Memory Consolidation of Fear Conditioning through MAPK Pathway in the Hippocampus
Porto RR, et al.
Neuroscience, 375, 108-118 (2018)
JNK Signaling in Apoptosis
Dhanasekaran DN, et al.
Oncogene, 27(48), 6245-6245 (2008)
Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells
Rodriguez HMA, et al.
Journal of Cellular Physiology, 234(1), 692-708 (2019)
Esophageal squamous cell carcinomas with distinct invasive depth show different gene expression profiles associated with lymph node metastasis
Sato T, et al.
International Journal of Oncology, 28(5), 1043-1055 (2006)

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