Merck

SAB4700751

Sigma-Aldrich

Monoclonal Anti-CD28 antibody produced in mouse

clone CD28.2, purified immunoglobulin, buffered aqueous solution

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别名:
Anti-MFASCD28-P
NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

CD28.2, monoclonal

形式

buffered aqueous solution

种属反应性

human, nonhuman primates

浓度

1 mg/mL

技术

FUNC: suitable
flow cytometry: suitable
immunoblotting: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

同位素/亚型

IgG1

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

2-8°C

靶向翻译后修饰

unmodified

基因信息

human ... CD28(940)

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此商品
SAB4700135SAB4700394SAB4701090
Sigma-Aldrich

SAB4700135

单克隆抗 CD28 小鼠抗

clone

CD28.2, monoclonal

clone

CD28.2, monoclonal

clone

MEM-101A, monoclonal

clone

SN3, monoclonal

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

species reactivity

human, nonhuman primates

species reactivity

nonhuman primates, human

species reactivity

human, pig, canine

species reactivity

-

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

Allophycocyanin conjugate

Gene Information

human ... CD28(940)

Gene Information

human ... CD28(940)

Gene Information

human ... ITGB1(3688)

Gene Information

human ... CD24(100133941)

一般描述

Cluster of differentiation 28 (CD 28) is a lymphocyte surface protein. In human chromosome, the gene CD28 is localized on 2q33.2. The antibody CD28.2 reacts with CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells. HLDA V.; WS Code 5T CD28.05.

免疫原

DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA

生化/生理作用

Cluster of differentiation 28 (CD28) acts as a costimulatory molecule for T cell activation and proliferation. CD28 might function as a tumor suppressor gene and the polymorphism is related to increased risk of breast cancer. CD28 plays a key role in allogenic responses. The level of CD28 is upregulated in CD4+ lymphocytes during acute graft rejection. Polymorphism in CD28 owing to higher frequency of CD28 molecule has impact on schizophrenia. Mutations in CD28 is associated with T cell lymphoma′s and neoplasm, leading to accelerated tumour growth. CD28 along with phosphatidylinositol 3 kinase (PI3K) regulates diverse biochemical pathways. CD28 signals to T cells and prevents anergy and apoptosis and promotes T cell proliferation and production of interleukin-2.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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A point mutation in CD28 distinguishes proliferative signals from survival signals
Okkenhaug K, et al.
Nature Immunology, 2(4), 325-332 (2001)
CD28 biomarker quantification and expression level profiles in CD4+ T-lymphocytes in solid organ transplantation
Boix F, et al.
Transplant Immunology, 42, 9-17 (2017)
Polymorphisms in immune-inflammatory response genes and the risk of deficit schizophrenia
Mak M, et al.
Schizophrenia Research, 193, 359-363 (2018)
Use of flow-sorted canine chromosomes in the assignment of canine linkage, radiation hybrid, and syntenic groups to chromosomes: refinement and verification of the comparative chromosome map for dog and human
Sargan D, et al.
Genomics, 69(2), 182-195 (2000)
The association between CD28 gene rs3116496 polymorphism and breast cancer risk in Chinese women
Yan Y and Zhang X
Bioscience Reports, 37(6), BSR20170884-BSR20170884 (2017)

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