Merck
  • T1408
All Photos(2)

T1408

Sigma-Aldrich

全转铁蛋白 牛

Synonym(s):
嗜铁蛋白, 嗜铁蛋白,铁饱和
CAS Number:
EC 号:
MDL编号:
NACRES:
NA.61

生物来源

bovine

质量水平

检测方案

97-100% (agarose gel electrophoresis)

形式

powder

technique(s)

cell culture | mammalian: suitable

UniProt登记号

储存温度

2-8°C

Gene Information

bovine ... TF(280705)

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1 of 4

This Item
T4132T1283T1428
holo-Transferrin bovine

Sigma-Aldrich

T1408

全转铁蛋白 牛

holo-Transferrin human ≥98%

Sigma-Aldrich

T4132

全转铁蛋白 人

holo-Transferrin bovine Iron-saturated, BioReagent, suitable for cell culture

Sigma-Aldrich

T1283

全转铁蛋白 牛

biological source

bovine

biological source

human

biological source

-

biological source

bovine

assay

97-100% (agarose gel electrophoresis)

assay

≥98%

assay

97-100% (agarose gel electrophoresis)

assay

≥98%

form

powder

form

powder

form

powder

form

powder

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

Q29443

UniProt accession no.

P02787

UniProt accession no.

Q29443

UniProt accession no.

Q29443

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

一般描述

Holo-Transferrin is an iron transporting glycoprotein and belongs to metalloprotein class. The gene encoding transferrin is mapped to bovine chromosome 1.

应用

Holo-Transferrin bovine has been used:
  • as a RPMI-1640 medium supplement for culturing cancer cell lines
  • as a component of visceral fat differentiation medium for the pre-adipocytes primary cell culture
  • to test the influence of iron-saturation complex on the growth of Malassezia pachydermatis
  • as a standard for strong anion exchange (SAX) reactor measurements

生化/生理作用

Holo-Transferrin (holo-Tf) or the iron bound transferrin functions as an iron sequester and is crucial for defense against microbial infections. Transferrin is used as a model system for understanding the kinetics and dynamics of protein structure based interactions. It is a potential candidate for delivery studies for its ability to cross the blood-brain barrier. The interaction of holo-Tf with thrombin is implicated in the pathogenesis of intracerebral hemorrhage. Polymorphisms in the bovine transferrin gene has led to the generation of 10 variant transferrin protein.
Studies show that treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.

分析说明

经琼脂糖凝胶电泳纯度。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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