T2036

脱铁转铁蛋白 人

powder, BioReagent, suitable for cell culture, ≥98% (agarose gel electrophoresis)

• Synonym(s): 人转铁蛋白, 铁传递蛋白
• CAS Number: 11096-37-0
• EC 号: 234-318-8
• MDL编号: MFCD00130536
• NACRES: NA.75

Properties

• 产品线: BioReagent
• 质量水平: 200
• 测定: ≥98% (agarose gel electrophoresis)
• 形式: powder
• 分子量: 76-81 kDa
• 浓度: ~25 mM
• technique(s): cell culture | mammalian: suitable
• 杂质: HIV and HBsAg, source material tested negative; endotoxin, tested
• 溶解性: H₂O: 50 mg/mL
• 痕量阳离子: Fe: ≤0.005%
• UniProt登记号: P02787
• 运输: ambient
• 储存温度: −20°C
• Gene Information: human ... TF(7018)

Description

一般描述

Transferrin, majorly synthesized in the liver, is an abundant glycoprotein in the serum. The members of the transferrin superfamily have similar polypeptide folding patterns. Transferrin contains N- and C-terminal iron-binding homologous domains. Each of these domains is split into two subdomains having binding sites for iron and anions within the inter-subdomain cleft. The binding cleft opens and closes with iron releasing and iron binding. apo-Transferrin is an iron-free protein that arises after transferrin dissociates from its receptor. This product can be supplemented with iron or used to bind free iron present in media.

应用

apo-Transferrin human has been used:

• to culture human primary pancreatic endothelial cells, Het1As (non-tumorous esophagus cells), and immortalized human colonic epithelial cells (HCEC-1CT)
• to culture α mouse liver 12 (AML-12) (mature hepatocytes) cells
• as a source for human apo-transferrin for purification before crystallography

生化/生理作用

Transferrin is responsible for transporting iron from the sites of absorption and storage to the tissue cells. It maintains the levels of iron in biological fluids. The levels of transferrin may indicate the total iron-binding capacity (TIBC). Transferrin supplies the required iron for incorporation into hemoglobin within RBCs in the bone marrow. Iron deficiency causes an increase in the levels of transferrin. Pregnancy and estrogen administration can also raise the levels of transferrin. Chronic liver disease, renal insufficiency, malnutrition, and protein-losing enteropathies reduce the synthesis of transferrin.

其他说明

非血红素铁转运蛋白。

Safety Information

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3