T2252

脱铁转铁蛋白 人

≥95% protein basis (biuret)

• Synonym(s): 人转铁蛋白, 铁传递蛋白
• CAS Number: 11096-37-0
• EC 号: 234-318-8
• MDL编号: MFCD00130536
• NACRES: NA.61

Properties

• 生物来源: human
• 质量水平: 200
• 测定: ≥95% protein basis (biuret); ≥98% (agarose gel electrophoresis)
• 形式: powder
• 分子量: 76-81 kDa
• technique(s): cell culture | mammalian: suitable
• 溶解性: H₂O: 50 mg/mL
• UniProt登记号: P02787
• 运输: wet ice
• 储存温度: −20°C
• Gene Information: human ... TF(7018)

Description

一般描述

Transferrin is a bilobed glycoprotein containing an N-terminal lobe and a C-terminal lobe. Each of these domains is divided into two sub-domains and within the inter subdomain cleft is the metal-binding site. A single transferrin molecule can bind to two ferric ions. Apo-transferrin is an iron-free form.

应用

转铁蛋白可以强烈抑制细菌与生物材料的粘附，包括聚苯乙烯、聚甲基丙烯酸甲酯和硅氧烷。在培养基中，20 ug/ml 可以观察到抑制作用 。

apo-Transferrin human has been used in Dulbecco′s Modified Eagle Medium/Nutrient Mixture F-12 to culture:

• pancreatic ductal adenocarcinoma (PDAC) cell lines
• oligodendrocytes
• renal proximal tubule epithelial cells (RPTEC/TERT1) cells

生化/生理作用

Transferrin transports iron through receptor-mediated endocytosis. The iron transport mechanism occurs in the endothelial cells of the blood-brain barrier. Transferrin maintains iron homeostasis and is an iron-associated marker. Reduced levels of transferrin are observed in severe COVID-19 conditions. It may bind to other molecules apart from iron, hence it can be used in targeted drug delivery.

其他说明

非血红素铁转运蛋白。

Safety Information

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3