Merck
All Photos(2)

T3258

Sigma-Aldrich

四环素

98.0-102.0% (HPLC)

Empirical Formula (Hill Notation):
C22H24N2O8 · xH2O
CAS Number:
Molecular Weight:
444.43 (anhydrous basis)
Beilstein:
2230417
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.85

质量水平

200

测定

98.0-102.0% (HPLC)

形式

powder or crystals

储存条件

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

颜色

faint yellow to dark yellow

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES string

CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

InChI key

OFVLGDICTFRJMM-WESIUVDSSA-N

Gene Information

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Related Categories

一般描述

Chemical structure: tetracycline

包装

5, 25 g in poly bottle

生化/生理作用

作用机制:四环素通过细胞膜中的 proin 通道被动扩散,与 30S 核糖体结合,并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合,改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用,这表明起到抗菌作用的是可逆结合的抗生素,而不是不可逆结合的药物。

耐药性机制:这种作用通过细胞壁通透性的丧失而失活。

抗菌谱:包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。

其他说明

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

警示用语:

Warning

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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