Merck

WH0001639M1

Sigma-Aldrich

Monoclonal Anti-DCTN1 antibody produced in mouse

clone 1E12, purified immunoglobulin, buffered aqueous solution

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别名:
Anti-DAP150, Anti-DP150, Anti-P135, Anti-dynactin 1 (p150, glued homolog, Drosophila)
NACRES:
NA.41

生物来源

mouse

偶联物

unconjugated

抗体形式

purified immunoglobulin

antibody product type

primary antibodies

克隆

1E12, monoclonal

形式

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: 1-5 μg/mL

同位素/亚型

IgG1λ

GenBank® accession no.

UniProt登记号

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... DCTN1(1639)

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此商品
SAB1403726WH0010540M1SAB1402168
species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

clone

1E12, monoclonal

clone

2E4-1C2, monoclonal

clone

2G7, monoclonal

clone

2E11, monoclonal

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

Gene Information

human ... DCTN1(1639)

Gene Information

human ... DCTN1(1639)

Gene Information

human ... DCTN2(10540)

Gene Information

human ... DBN1(1627)

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

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一般描述

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). (provided by RefSeq)

免疫原

DCTN1 (AAH06163, 1 a.a. ~ 198 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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