Merck

X0626

Sigma-Aldrich

黄嘌呤

≥99.5% (HPLC), purified by recrystallization

别名:
2,6-二羟基嘌呤
Empirical Formula (Hill Notation):
C5H4N4O2
CAS号:
分子量:
152.11
Beilstein:
8733
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.51

质量水平

检测方案

≥99.5% (HPLC)

纯化方式

recrystallization

溶解性

1 M NaOH: soluble 50 mg/mL, clear, colorless to faintly yellow

SMILES string

O=C1NC(=O)c2nc[nH]c2N1

InChI

1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11)

InChI key

LRFVTYWOQMYALW-UHFFFAOYSA-N

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此商品
X4002X2502X3627
Xanthine ≥99.5% (HPLC), purified by recrystallization

Sigma-Aldrich

X0626

黄嘌呤

Xanthine BioUltra, ≥99%

Sigma-Aldrich

X4002

黄嘌呤

Xanthine sodium salt ≥99%

Sigma-Aldrich

X2502

黄嘌呤 钠盐

Xanthine sodium salt suitable for cell culture, ≥99%

Sigma-Aldrich

X3627

黄嘌呤 钠盐

solubility

1 M NaOH: soluble 50 mg/mL, clear, colorless to faintly yellow

solubility

1 M NaOH: 0.1 M, clear, colorless to light yellow

solubility

dilute NaOH: soluble, clear to slightly hazy

solubility

1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to light yellow

purified by

recrystallization

purified by

-

purified by

-

purified by

-

一般描述

黄嘌呤及其衍生物的天然来源包括动物器官、酵母、土豆、咖啡豆和茶叶。作为一种嘌呤,黄嘌呤由嘌呤代谢通路中的几种不同前体生成:鸟嘌呤脱氨酶催化的鸟嘌呤脱氨和黄嘌呤氧化还原酶催化的次黄嘌呤转化。

应用

黄嘌呤已用于黄嘌呤-氧化酶-细胞色素c还原法测定超氧化物歧化酶活性。还用作底物,测定不同牛奶中的黄嘌呤氧化酶活性

生化/生理作用

黄嘌呤和黄嘌呤氧化酶可用于生成超氧自由基,测定超氧化物歧化酶的活性。黄嘌呤在嘌呤代谢中是尿酸的前体代谢物。黄嘌呤已被指定为特定疾病的生物标志物,例如痛风。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


Certificates of Analysis (COA)

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货号
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25G
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Hypoxanthine powder, BioReagent, suitable for cell culture

Sigma-Aldrich

H9636

次黄嘌呤

Allopurinol xanthine oxidase inhibitor

Sigma-Aldrich

A8003

别嘌醇

Mycophenolic acid powder, BioReagent, suitable for cell culture

Sigma-Aldrich

M3536

霉酚酸

Xanthine sodium salt ≥99%

Sigma-Aldrich

X2502

黄嘌呤 钠盐

P Leanderson et al.
Carcinogenesis, 17(3), 545-550 (1996-03-01)
The formation of DNA-strand breaks was studied in cultured human lung cells (A 549) subjected to iron, either in the form of iron(III) citrate or in combination with the metal chelators ethylene diamine tetra-acetic acid (EDTA), nitrilo triacetic acid (NTA)
Different processed milk with residual xanthine oxidase activity and risk of increasing serum uric acid level
Sha W, et al.
Food Bioscience, 40, 100892-100892 (2021)
Bioactive chemical constituents of Stereospermum kunthianum (Bignoniaceae)
Island, W
Research Journal of Phytochemistry, 3, 35-43 (2009)
Physiological acclimation to gradients of solar irradiance within mats of the filamentous green macroalga Chaetomorpha linum from southern Spain.
Bischof, Kai, et al.
Marine Ecology Progress Series, 306, 165-175 (2006)
Oxidative stress and enzymatic scavenging of superoxide radicals induced by solar UV-B radiation in Ulva canopies from southern Spain.
Bischof, Kai, et al.
Scientia Marina, 67, 353-359 (2003)

商品

HPLC Analysis of Xanthines on Purospher® STAR RP-18 endcapped

Xanthine is a purine base found in most human body tissues and fluids as well as in other organisms. Methylated xanthines (methylxanthines), which include caffeine, paraxanthine, theobromine, and theophylline, commonly used for their effects as mild stiµlants and as bronchodilators, notably in the treatment of asthma symptoms. This application shows the efficient separation of several common xanthines and may be applied their analysis in any number of desired matrices.

实验方案

超氧化物歧化酶的酶学测定

在测定超氧化物歧化酶活性时,使用了一种在550 nm处的连续分光光度法进行测定。一个酶单位可将酶偶联系统的细胞色素c还原率抑制50%。

Enzymatic Assay of Superoxide Dismutase

Enzymatic Assay of Superoxide Dismutase

相关内容

HPLC Analysis of Xanthines on Purospher® STAR RP-18 endcapped

Separation of Hypoxanthine, ≥99.0%; Xanthine, ≥99%; 7-Methylxanthine, ≥98.0% (HPLC); 3-Methylxanthine; 1-Methylxanthine, ≥97.0% (HPLC); Theobromine, ≥98.0%; 1,7-Dimethylxanthine, ~98%, solid; Theophylline, anhydrous, ≥99%, powder; Specimen capsules, microporous, average pore diameter 120 μm

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