Merck

X7375

Sigma-Aldrich

黄嘌呤

≥99%

别名:
2,6-二羟基嘌呤
Empirical Formula (Hill Notation):
C5H4N4O2
CAS号:
分子量:
152.11
Beilstein:
8733
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.51

生物来源

synthetic (organic)

检测方案

≥99%

形式

powder

溶解性

1 M NaOH: soluble 50 mg/mL, clear to slightly hazy
NH4OH: freely soluble
NaOH: freely soluble

SMILES string

O=C1NC(=O)c2nc[nH]c2N1

InChI

1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11)

InChI key

LRFVTYWOQMYALW-UHFFFAOYSA-N

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此商品
X0626X4002526460
Xanthine ≥99%

Sigma-Aldrich

X7375

黄嘌呤

Xanthine ≥99.5% (HPLC), purified by recrystallization

Sigma-Aldrich

X0626

黄嘌呤

Xanthine BioUltra, ≥99%

Sigma-Aldrich

X4002

黄嘌呤

assay

≥99%

assay

≥99.5% (HPLC)

assay

≥99%

assay

97%

form

powder

form

-

form

powder

form

-

solubility

1 M NaOH: soluble 50 mg/mL, clear to slightly hazy, NH4OH: freely soluble, NaOH: freely soluble

solubility

1 M NaOH: soluble 50 mg/mL, clear, colorless to faintly yellow

solubility

1 M NaOH: 0.1 M, clear, colorless to light yellow

solubility

-

Quality Level

300

Quality Level

400

Quality Level

200

Quality Level

300

一般描述

黄嘌呤是在鸟嘌呤脱氨酶存在的情况下由鸟嘌呤合成。黄嘌呤氧化酶催化由次黄嘌呤生成黄嘌呤并随后分解为尿酸。黄嘌呤衍生物存在于咖啡、茶和可可种子中。黄嘌呤被认为是生成药理活性化合物的先导物。

应用

黄嘌呤已用于构巢曲霉转运试验中的非放射性标记底物混合物。它还被用作黄嘌呤氧化酶的底物,用于鳃细胞和藻类细胞产生超氧阴离子。

生化/生理作用

高水平黄嘌呤与自毁容貌综合征等代谢紊乱有关。基于黄嘌呤的生物传感器可用于检测食品和临床样品中的黄嘌呤。肾衰竭、痛风和黄嘌呤尿患者的血液和尿液样本均显示高水平的黄嘌呤。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


Certificates of Analysis (COA)

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示例

T1503
货号
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25G
包装规格/数量

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1000309185

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Sigma-Aldrich

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次黄嘌呤

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CDS020790

黄嘌呤核苷

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Sigma-Aldrich

U2625

尿酸

Transport Assays in Aspergillus nidulans
Krypotou E and Diallinas G
Molecular Microbiology, 3(22), 1-5 (2013)
Biosensing methods for xanthine determination: a review
Pundir CS and Devi R
Enzyme and Microbial Technology, 57, 55-62 (2014)
Study on detection methods for xanthine in food and biological samples
Wu S, et al.
Int. J. Curr. Res. Chem. Pharma. Sci, 3(8), 1-5 (2016)
D L Krebs et al.
Methods in cell science : an official journal of the Society for In Vitro Biology, 21(1), 57-68 (2000-03-25)
Murine B cell lines such as WEHI-231, BAL17 and M12.4.1 are frequently used as model systems to study signal transduction, cell cycle regulation, and apoptosis. Dissection of these processes often involves expressing exogenous genes in these cells. Electroporation is an
Xanthine scaffold: scope and potential in drug development
Singh N, et al.
Heliyon, 4(10), e00829-e00829 (2018)

商品

Uric Acid in Cell Culture

Uric acid is not a direct additive to any of the classical cell culture media. However, it is present in animal sera. Consequently, uric acid is typically present in complete serum-supplemented classical cell culture systems.

HPLC Analysis of Xanthines on Purospher® STAR RP-18 endcapped

Xanthine is a purine base found in most human body tissues and fluids as well as in other organisms. Methylated xanthines (methylxanthines), which include caffeine, paraxanthine, theobromine, and theophylline, commonly used for their effects as mild stiµlants and as bronchodilators, notably in the treatment of asthma symptoms. This application shows the efficient separation of several common xanthines and may be applied their analysis in any number of desired matrices.

相关内容

Uric Acid in Cell Culture

Uric acid is not a direct additive to any of the classical cell culture media. However, it is present in animal sera. Consequently, uric acid is typically present in complete serum-supplemented classical cell culture systems.

HPLC Analysis of Xanthines on Purospher® STAR RP-18 endcapped

Separation of Hypoxanthine, ≥99.0%; Xanthine, ≥99%; 7-Methylxanthine, ≥98.0% (HPLC); 3-Methylxanthine; 1-Methylxanthine, ≥97.0% (HPLC); Theobromine, ≥98.0%; 1,7-Dimethylxanthine, ~98%, solid; Theophylline, anhydrous, ≥99%, powder; Specimen capsules, microporous, average pore diameter 120 μm

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