Merck
Search Within

03978

应用筛选条件
关键词:'03978'
显示 1-30 共 291 条结果 关于 "03978" 范围 论文
Jelena Levi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(14), 3721-3729 (2014-05-23)
To evaluate the utility of targeted photoacoustic imaging (PAI) in providing molecular information to complement intrinsic functional and anatomical details of the vasculature within prostate lesion. We developed a PAI agent, AA3G-740, that targets gastrin-releasing peptide receptor (GRPR), found to
Allison Auchter et al.
Journal of Alzheimer's disease : JAD, 42 Suppl 4, S525-S535 (2014-08-01)
Chronic cerebral hypoperfusion, a risk factor for mild cognitive impairment and Alzheimer's disease, affects mitochondrial respiration and memory consolidation. Therefore, drugs that improve mitochondrial function may be appropriate cognitive treatments for cerebral hypoperfusion. Methylene blue (MB) crosses the blood-brain barrier
Ashok A Kumar et al.
American journal of hematology, 90(1), 31-36 (2014-09-30)
This paper demonstrates the enrichment of reticulocytes by centrifuging whole blood through aqueous multiphase systems (AMPSs)-immiscible phases of solutions of polymers that form step-gradients in density. The interfaces of an AMPS concentrate cells; this concentration facilitates the extraction of blood
Lei Guo et al.
Carbohydrate polymers, 93(2), 374-379 (2013-03-19)
Crosslinked porous starch (CPS) was prepared by two steps. Native starch was crosslinked with epichlorohydrin and then CPS was prepared by hydrolyzing the crosslinked starch with α-amylase. As a biodegradable and safe adsorbent, CPS was used to remove methylene blue
Catherine Kamtchueng et al.
PloS one, 9(7), e102399-e102399 (2014-07-16)
The TAF6δ pathway of apoptosis can dictate life versus death decisions independently of the status of p53 tumor suppressor. TAF6δ is an inducible pro-apoptotic subunit of the general RNA polymerase II (Pol II) transcription factor TFIID. Alternative splice site choice
Yuko Mitobe et al.
Regulatory toxicology and pharmacology : RTP, 71(3), 529-540 (2015-02-24)
Japanese cedar (JC) pollinosis is caused by Japanese cedar pollen (JCP) and most common seasonal allergic disease in Japan. Subcutaneous immunotherapy (SCIT) with allergen extract of JCP (JCP-allergen extract) is well established for JC pollinosis treatment with improvement of symptoms.
Gustavo A Higuera et al.
Biomaterials, 61, 190-202 (2015-05-26)
Cells and tissues are intrinsically adapted to molecular gradients and use them to maintain or change their activity. The effect of such gradients is particularly important for cell populations that have an intrinsic capacity to differentiate into multiple cell lineages
Cécile Voisset et al.
Disease models & mechanisms, 7(4), 435-444 (2014-02-22)
Epstein-Barr virus (EBV) is tightly associated with certain human cancers, but there is as yet no specific treatment against EBV-related diseases. The EBV-encoded EBNA1 protein is essential to maintain viral episomes and for viral persistence. As such, EBNA1 is expressed
Ad de Ruiter et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 42(5), 460-468 (2013-07-16)
The purpose of this study was to evaluate the use of synthetic bone graft material as a filling material at the mandibular symphysis donor site of autologous bone in children. A blinded patient group comprised 20 patients with unilateral (UCLP)
Aihua Li et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 20(40), 12945-12953 (2014-08-12)
The preparation of thermoresponsive drug carriers with a self-destruction property is presented. These drug carriers were fabricated by incorporation of drug molecules and thermoresponsive copolymer, poly(N-isopropylacrylamide-co-acrylamide), into silica nanoparticles in a one-pot preparation process. The enhanced drug release was primarily
Masami Watanabe
International journal of oncology, 47(3), 875-883 (2015-07-03)
Focal ablation therapy is an emerging treatment modality for localized cancer lesions. It is an attractive strategy for inhibiting tumor progression and preventing morbidity associated with open surgery. As for intratissue drug delivery systems for use in local therapy, the
Jonel Steffen et al.
The British journal of ophthalmology, 98(1), 13-15 (2013-10-26)
To evaluate the diagnostic accuracy of methylene blue used as a non-invasive in vivo stain to detect ocular surface squamous neoplasia (OSSN). A test validation study was performed according to Standards for the reporting of diagnostic accuracy studies (STARD) guidelines
Hossein Hosseinzadeh et al.
Carbohydrate polymers, 134, 213-221 (2015-10-03)
This study investigated the potential use of quince seed mucilage (QSM) as alternative bioadsorbents for methylene blue (MB) dye from aqueous solutions. This novel magnetic nanocomposite adsorbent (MNCA) based on QSM was synthesized by in situ formation of magnetic iron
Mayra Araguaia Pereira Figueiredo et al.
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, 24(2), 122-128 (2015-07-15)
The states that make up the Legal Amazon Region, which include the state of Maranhão, account for 99% of registered cases of human malaria in Brazil. It is also believed that transmission of malaria from nonhuman primates (NHP) to humans
Zalilah Tapsir et al.
The journal of contemporary dental practice, 14(1), 47-50 (2013-04-13)
To evaluate and compare the microleakage of various restorative materials used as coronal barriers between endodontic appointments. Eighty extracted human permanent posterior teeth were prepared for standardized access cavities with dimensions of 4 × 4 × 4 mm. The teeth
Alex Crowe et al.
The Journal of biological chemistry, 288(16), 11024-11037 (2013-02-28)
Alzheimer disease and several other neurodegenerative disorders are characterized by the accumulation of intraneuronal fibrils comprised of the protein Tau. Tau is normally a soluble protein that stabilizes microtubules, with splice isoforms that contain either three (3-R) or four (4-R)
Alexandre Kaempfen et al.
International journal of molecular sciences, 16(6), 12616-12630 (2015-06-09)
The gold standard treatment of large segmental bone defects is autologous bone transfer, which suffers from low availability and additional morbidity. Tissue engineered bone able to engraft orthotopically and a suitable animal model for pre-clinical testing are direly needed. This
Joseph Tuffour et al.
The American journal of tropical medicine and hygiene, 93(2), 216-223 (2015-06-10)
The synergy between Mycobacterium tuberculosis infection and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome is well established but not so in Buruli ulcer (BU). We screened confirmed BU cases for HIV infection and followed seven BU/HIV-coinfected patients. Management of BU/HIV was
W Yang et al.
European cells & materials, 27, 350-364 (2014-06-11)
In the context of skeletal tissue development and repair, endochondral ossification has inspired a new approach to regenerate bone tissue in vivo using a cartilage intermediate as an osteoinductive template. The aim of this study was to investigate the behavior
Jhon A Ochoa-Alvarez et al.
Oncotarget, 6(11), 9045-9060 (2015-04-01)
Podoplanin (PDPN) is a unique transmembrane receptor that promotes tumor cell motility. Indeed, PDPN may serve as a chemotherapeutic target for primary and metastatic cancer cells, particularly oral squamous cell carcinoma (OSCC) cells that cause most oral cancers. Here, we
Nicholas J D Wright et al.
Invertebrate neuroscience : IN, 15(1), 175-175 (2014-11-09)
The generation of the novel messenger molecule nitric oxide (NO) has been demonstrated in many tissues across phyla including nervous systems. It is produced on demand by the enzyme nitric oxide synthase often stimulated by intracellular calcium and typically affecting
Xiaoqiang Cong et al.
Molecular medicine reports, 9(6), 2528-2532 (2014-04-01)
The role of resveratrol (Res) in inflammation induced by ischemia/reperfusion is not well understood. The aim of the present study was to investigate whether Res modulates neutrophil accumulation and tumor necrosis factor-α (TNF-α) induction in an ischemia/reperfusion-injured rat heart model.
Peijun Xu et al.
Advances in experimental medicine and biology, 827, 187-203 (2014-11-13)
Different quantum mechanic methods have been evaluated for the calculation of binding modes and interactions between intercalators with different DNA base pairs by comparing with the results of MP2, which is very expensive, indicating that WB97XD method under 6-311+G* basis
Ben Aernouts et al.
Optics express, 23(20), 26049-26063 (2015-10-21)
In many research areas and application domains, the bulk optical properties of biological materials are of great interest. Unfortunately, these properties cannot be obtained easily for complex turbid media. In this study, a metamodeling approach has been proposed and applied
Ahmed Ebraheem Al Subaie et al.
Journal of clinical periodontology, 42(7), 688-696 (2015-06-16)
To assess the effect of anti-vascular endothelial growth factors (VEGF) on bone healing (defect volume) and implant osseointegration (bone-implant contact per cent) in rat tibia. In Sprague-Dawley rats (n = 36), a unicortical defect was created in the right tibia
Chang Hee Woo et al.
Journal of biomaterials science. Polymer edition, 26(13), 841-854 (2015-06-23)
We designed bilayer composites composed of an upper layer of titanium dioxide (TiO2)-incorporated chitosan membrane and a sub-layer of human adipose-derived extracellular matrix (ECM) sheet as a wound dressing for full-thickness wound healing. The dense and fibrous top layer, which
Methylene blue for refractory anaphylaxis--is it a magic bullet? The authors' response.
Cindy S Bauer et al.
The American journal of emergency medicine, 31(7), 1140-1141 (2013-05-18)
Nouruddin Wageih Ali et al.
Pakistan journal of pharmaceutical sciences, 26(3), 641-648 (2013-04-30)
Validated spectrophotometric and chemometric methods were developed for determination of Naphazoline Hydrochloride (NAP), Chlorpheniramine maleate (CLO) and Methylene blue (MB) in their ternary mixture. Method A was a spectrophotometric method, where NAP and MB were determined using second derivative (D²)
D C Riley et al.
Journal of neuroscience research, 93(4), 572-583 (2014-11-27)
Restoration of neuronal functions by outgrowths regenerating at ∼1 mm/day from the proximal stumps of severed peripheral nerves takes many weeks or months, if it occurs at all, especially after ablation of nerve segments. Distal segments of severed axons typically
C Riccó et al.
The Veterinary record, 173(24), 608-608 (2013-10-26)
To compare different volumes of injectate using electrostimulator (ES)-guided and blind brachial plexus blockade (BPB) techniques in dogs. Prospective, randomised, blinded study. Fifty-eight healthy adult purpose-bred beagle dogs. Animals were randomised into 4 groups based on the volume of methylene
1/10