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Sergio Rodríguez-Arévalo et al.
Molecules (Basel, Switzerland), 26(4) (2021-02-13)
AR-15512 (formerly known as AVX-012 and WS-12) is a TRPM8 receptor agonist currently in phase 2b clinical trials for the treatment of dry eye. This bioactive compound with menthol-like cooling activity has three stereogenic centers, and its final structure and
Jennifer L Dale et al.
Antimicrobial agents and chemotherapy, 59(7), 4094-4105 (2015-04-29)
The emergence of multidrug-resistant bacteria and the limited availability of new antibiotics are of increasing clinical concern. A compounding factor is the ability of microorganisms to form biofilms (communities of cells encased in a protective extracellular matrix) that are intrinsically
Kendra J Alfson et al.
Journal of virology, 89(13), 6773-6781 (2015-04-24)
This study addresses the role of Ebola virus (EBOV) specific infectivity in virulence. Filoviruses are highly lethal, enveloped, single-stranded negative-sense RNA viruses that can cause hemorrhagic fever. No approved vaccines or therapies exist for filovirus infections, and infectious virus must
Wei Jie Seow et al.
Carcinogenesis, 36(8), 852-857 (2015-04-25)
Formaldehyde has been classified as a human myeloid leukemogen. However, the mechanistic basis for this association is still debated. We aimed to evaluate whether circulating immune/inflammation markers were altered in workers occupationally exposed to formaldehyde. Using a multiplexed bead-based assay
Jolene Read et al.
PLoS pathogens, 11(6), e1004962-e1004962 (2015-06-11)
Pore formation is the most energy-demanding step during virus-induced membrane fusion, where high curvature of the fusion pore rim increases the spacing between lipid headgroups, exposing the hydrophobic interior of the membrane to water. How protein fusogens breach this thermodynamic
Mai Nakayachi et al.
Bone, 75, 170-182 (2015-03-07)
Inflammatory bone diseases have been attributed to increased bone resorption by augmented and activated bone-resorbing osteoclasts in response to inflammation. Although the production of diverse proinflammatory cytokines is induced at the inflamed sites, the inflammation also generates reactive oxygen species
Yíngyún Caì et al.
PloS one, 9(11), e112060-e112060 (2014-11-20)
Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently isolated betacoronavirus identified as the etiologic agent of a frequently fatal disease in Western Asia, Middle East respiratory syndrome. Attempts to identify the natural reservoirs of MERS-CoV have focused in part
Ki Yeon Kim et al.
Molecules and cells, 38(6), 548-561 (2015-05-28)
By combining conventional single cell analysis with flow cytometry and public database searches with bioinformatics tools, we extended the expression profiling of thymic stromal cotransporter (TSCOT), Slc46A2/Ly110, that was shown to be expressed in bipotent precursor and cortical thymic epithelial
Yolanda Karla Cupertino da Silva et al.
Molecules (Basel, Switzerland), 19(6), 8456-8471 (2014-06-24)
Different chemotypes are described as anti-inflammatory. Among them the N-acylhydrazones (NAH) are highlighted by their privileged structure nature, being present in several anti-inflammatory drug-candidates. In this paper a series of functionalized 3-aminothiophene-2-acylhydrazone derivatives 5a-i were designed, synthesized and bioassayed. These
Wei Ding et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 774, 1-7 (2014-12-03)
Cyproterone acetate (CPA), a synthetic hormonal drug, induces rat liver tumors in a sex-specific manner, with five-fold higher doses needed to induce liver tumors in male rats compared to females. In order to evaluate the potential of the in vivo
Sang Woo Seo et al.
Nature communications, 6, 7970-7970 (2015-08-11)
The regulators GadE, GadW and GadX (which we refer to as GadEWX) play a critical role in the transcriptional regulation of the glutamate-dependent acid resistance (GDAR) system in Escherichia coli K-12 MG1655. However, the genome-wide regulatory role of GadEWX is
M Waheed Roomi et al.
Experimental and therapeutic medicine, 10(3), 901-906 (2015-12-02)
Cervical cancer is one of the most commonly diagnosed cancers and a significant cause of mortality in women worldwide. Although cervical cancer is fully treatable in the early stages, once it has metastasized, patient outcome is poor. The objective of
Morgan H McCoy et al.
Human pathology, 45(1), 48-53 (2013-10-22)
Histopathologic diagnosis of gastrointestinal (GI) tract cytomegaloviral (CMV) infection relies on hematoxylin and eosin (H&E)-stained tissue, along with the aid of immunohistochemistry (IHC). However, non-classic appearing inclusions or atypical IHC staining patterns remain an ongoing concern for pathologists. We reported
Gwenaëlle Sana et al.
Cell transplantation, 23(9), 1127-1142 (2013-04-16)
The success of liver cell therapy remains closely dependent on how well the infused cells can be accepted after transplantation and is directly related to their degree of immunogenicity. In this study, we investigated the in vitro immunogenic properties of
Nobuki Furubayashi et al.
Oncology letters, 8(5), 2237-2242 (2014-10-09)
The aim of the present study was to evaluate the hypothesis that a positive resection margin (RM1) of an excised specimen may not reflect the true margin in patients that have undergone radical prostatectomy (RP). Between September 2003 and March
Adriana Rojas et al.
The Journal of biological chemistry, 290(47), 28329-28342 (2015-10-11)
Transcription factor Runx2 controls bone development and osteoblast differentiation by regulating expression of a significant number of bone-related target genes. Here, we report that transcriptional activation and repression of the Runx2 gene via its osteoblast-specific P1 promoter (encoding mRNA for
Hai-bo Cheng et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(6), 623-634 (2015-03-07)
Pancreatic cancer is a devastating disease with a poor prognosis. It ranks as the fourth or fifth most common cancer in men and women and has the lowest 5-year survival rate. Therefore, there is an urgent need to develop novel
Magdalena Stasiulewicz et al.
Development (Cambridge, England), 142(13), 2291-2303 (2015-05-23)
Notochord-derived Sonic Hedgehog (Shh) is essential for dorsoventral patterning of the overlying neural tube. Increasing concentration and duration of Shh signal induces progenitors to acquire progressively more ventral fates. We show that Notch signalling augments the response of neuroepithelial cells
Emmanuel João Nogueira Leal da Silva et al.
Journal of applied oral science : revista FOB, 21(1), 43-47 (2013-04-06)
The aim of the present study was to investigate the effects of root canal sealers on the cytotoxicity of 3T3 fibroblasts during a period of 5 weeks. Fibroblasts (3T3, 1×105 cells per well) were incubated with elutes of fresh specimens
Ayako Tabata-Imai et al.
PloS one, 9(8), e105282-e105282 (2014-08-19)
D-Serine, an endogenous coagonist of the N-methyl-D-aspartate receptor (NMDAR), is widely distributed in the central nervous system and is synthesized from L-serine by serine racemase (SR). NMDAR plays an important role in pain processing including central sensitization that eventually causes
Owen A Darr et al.
Head & neck, 37(7), 994-1001 (2014-04-05)
Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are the 2 most common cutaneous carcinomas. Molecular profiles predicting metastasis of these cancers have not been identified. Epigenetic profiles of 37 primary cases of cutaneous SCC and BCC were quantified
Xiaoyan Xiao et al.
Molecular medicine reports, 12(3), 4043-4050 (2015-06-18)
Recent studies in animal models have revealed that mycophenolate mofetil (MMF) has certain protective effects against experimental diabetic nephropathy. The present study therefore aimed to investigate the hypothesis that diabetic nephropathy may be ameliorated by mycophenolate mofetil and benazepril treatment
Yu Liu et al.
American journal of translational research, 7(5), 967-975 (2015-07-16)
Resistance to single or multiple chemotherapeutic drugs is a major obstacle in breast cancer therapy. Recent studies have suggested that GPR30 is implicated in mediating cancer cell proliferation. The aim of this study was to examine the anti-tumor effects of
Jaime Pei Pei Foong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(18), 7106-7115 (2015-05-08)
Acetylcholine-activating pentameric nicotinic receptors (nAChRs) are an essential mode of neurotransmission in the enteric nervous system (ENS). In this study, we examined the functional development of specific nAChR subtypes in myenteric neurons using Wnt1-Cre;R26R-GCaMP3 mice, where all enteric neurons and
Ashleigh Poole et al.
Journal of cellular physiology, 231(3), 650-658 (2015-07-29)
Transient FGF stimulation of various cell types results in FGF memory--a sustained blockage of efficient proliferative response to FGF and other growth factors. FGF memory establishment requires HDAC activity, indicating its epigenetic character. FGF treatment stimulates proinflammatory NFκB signaling, which
Yan Cai et al.
BMC pulmonary medicine, 15, 72-72 (2015-07-17)
Secretoglobin (SCGB) 3A2, a cytokine-like secretory protein of small molecular weight, is predominantly expressed in airway epithelial cells. While SCGB3A2 is known to have anti-inflammatory, growth factor, and anti-fibrotic activities, whether SCGB3A2 has any other roles, particularly in lung homeostasis
Bailey T , et al. et al.
Science of Synthesis: Houben-Weyl Methods of Molecular Transformations, 21 (2014)
Alice Plein et al.
The Journal of clinical investigation, 125(7), 2661-2676 (2015-06-09)
In mammals, the outflow tract (OFT) of the developing heart septates into the base of the pulmonary artery and aorta to guide deoxygenated right ventricular blood into the lungs and oxygenated left ventricular blood into the systemic circulation. Accordingly, defective
Giulia Salvatore et al.
Journal of lipid research, 56(6), 1110-1122 (2015-04-03)
Interleukin 17A (IL-17A) is a proinflammatory cytokine involved in the pathogenesis of chronic inflammatory diseases. In the field of immunometabolism, we have studied the impact of IL-17A on the lipid metabolism of human in vitro-generated monocyte-derived dendritic cells (DCs). Microarrays
M Kalinichev et al.
British journal of pharmacology, 171(21), 4941-4954 (2014-06-14)
The GABA(B) receptor agonist, baclofen, has shown promising effects in patients suffering from pain, post-traumatic stress disorder, alcoholism, overactive bladder and gastroesophageal reflux disease. However, baclofen's short duration of action and side effects limit its wider use. Here we characterized
页码 1 来自 102
页码 1 来自 102