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关键词:'15512'
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15512

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Sergio Rodríguez-Arévalo et al.
Molecules (Basel, Switzerland), 26(4) (2021-02-13)
AR-15512 (formerly known as AVX-012 and WS-12) is a TRPM8 receptor agonist currently in phase 2b clinical trials for the treatment of dry eye. This bioactive compound with menthol-like cooling activity has three stereogenic centers, and its final structure and
Sandra Milena Bernal Ulloa et al.
Zygote (Cambridge, England), 23(3), 367-377 (2014-01-16)
Cyclic adenosine monophosphate (cAMP) modulators have been used to avoid spontaneous oocyte maturation and concomitantly improve oocyte developmental competence. The current work evaluated the effects of the addition of cAMP modulators forskolin, 3-isobutyl-1-methylxanthine (IBMX) and cilostamide during in vitro maturation
Elizabeth A Reznikov et al.
The Journal of nutrition, 144(9), 1401-1408 (2014-07-25)
Lactoferrin is a bioactive milk protein that stimulates cell proliferation in vitro; however, limited in vivo evidence exists to allow lactoferrin to be incorporated into infant formula. Herein, the effect of dietary bovine lactoferrin (bLF) on neonatal intestinal growth and
Ina Rosenberger et al.
Journal of controlled release : official journal of the Controlled Release Society, 194, 130-137 (2014-09-01)
Iron oxide-containing magnetic nanoparticles (MNPs) have certain advantages over currently used contrast agents for tumor imaging by magnetic resonance imaging (MRI) as they offer the possibility of functionalization with ligands and tracers. Functionalized MNPs also may be used for targeted
Aya D Pusic et al.
Experimental neurology, 264, 43-54 (2014-12-17)
Multiple sclerosis and migraine with aura are clinically correlated and both show imaging changes suggestive of myelin disruption. Furthermore, cortical myelin loss in the cuprizone animal model of multiple sclerosis enhances susceptibility to spreading depression, the likely underlying cause of
Remya Sreedhar et al.
Cellular signalling, 27(4), 770-776 (2015-01-21)
There is a definite cardioprotective role for 14-3-3η protein against pressure overload induced cardiac hypertrophy and streptozotocin induced cardiac dysfunction in type 1 diabetes mellitus (DM). But it is not conclusive whether it has any influence on mitochondrial mediated cardiomyocyte
Lijie Dong et al.
Cell and tissue research, 360(2), 233-243 (2015-02-02)
Pathological retinal neovascularization, including retinopathy of prematurity and age-related macular degeneration, is the most common cause of blindness worldwide. Insulin-like growth factor-1 (IGF-1) has a direct mitogenic effect on endothelial cells, which is the basis of angiogenesis. Vascular endothelial growth
Tsz Kin Ng et al.
Scientific reports, 5, 7828-7828 (2015-01-17)
Cigarette smoking contributes to the development of destructive periodontal diseases and delays its healing process. Our previous study demonstrated that nicotine, a major constituent in the cigarette smoke, inhibits the regenerative potentials of human periodontal ligament-derived stem cells (PDLSC) through
Ellen Senft et al.
International journal of oral science, 7(1), 18-22 (2014-07-12)
It is known that human papillomavirus (HPV) infection can cause squamous cell neoplasms at several sites, such as cervix uteri carcinoma and oral squamous carcinoma. There is little information on the expression of HPV and its predictive markers in tumours
Sarit Anavi et al.
Laboratory investigation; a journal of technical methods and pathology, 95(8), 914-924 (2015-06-23)
Accumulation of cholesterol in the liver is associated with the development of non-alcoholic steatohepatitis-related fibrosis. However, underlying mechanisms are not well understood. The present study investigated the role of inducible nitric oxide synthase (iNOS) in cholesterol-induced liver fibrosis by feeding
Jiahai Shi et al.
Pathology, research and practice, 211(9), 633-640 (2015-05-27)
Acute allograft rejection is initiated by a large number of recipient T cells that recognize donor alloantigens. Apoptotic signals trigger Nur77 production. Nur77 translocates from the nucleus to the mitochondria to induce a loss of mitochondrial membrane potential and the
Candice C Clay et al.
Journal of virology, 88(13), 7412-7425 (2014-04-18)
Influenza is the cause of significant morbidity and mortality in pediatric populations. The contribution of pulmonary host defense mechanisms to viral respiratory infection susceptibility in very young children is poorly understood. As a surrogate to compare mucosal immune responses of
Alok R Singh et al.
Experimental cell research, 327(1), 78-90 (2014-06-03)
Pattern recognition receptors (PRRs), e.g. toll receptors (TLRs) that bind ligands within the microbiome have been implicated in the pathogenesis of cancer. LPS is a ligand for two TLR family members, TLR4 and RP105 which mediate LPS signaling in B
Ashlee H Rowe et al.
Science (New York, N.Y.), 342(6157), 441-446 (2013-10-26)
Painful venoms are used to deter predators. Pain itself, however, can signal damage and thus serves an important adaptive function. Evolution to reduce general pain responses, although valuable for preying on venomous species, is rare, likely because it comes with
Junghyun Kim et al.
Molecular medicine reports, 12(1), 1075-1081 (2015-03-31)
The retinal accumulation of advanced glycation end products (AGEs) is a condition, which is found in diabetic retinopathy. The purpose of the present study was to investigate the protective effect of Litsea japonica extract (LJE) and to elucidate its underlying
C Egloff et al.
Osteoarthritis and cartilage, 22(11), 1886-1893 (2014-08-12)
Interactions between mechanical and non-mechanical independent risk factors for the onset and progression of Osteoarthritis (OA) are poorly understood. Therefore, the goal of the present study was to investigate the in vivo effects of muscle weakness, joint inflammation and the combination
Jessica Schmitt et al.
Molecular medicine (Cambridge, Mass.), 21, 185-196 (2015-03-27)
Parent-of-origin imprints have been implicated in the regulation of neural differentiation and brain development. Previously we have shown that, despite the lack of a paternal genome, human parthenogenetic (PG) embryonic stem cells (hESCs) can form proliferating neural stem cells (NSCs)
Catherine A Mayer et al.
Pediatric research, 78(2), 145-151 (2015-05-08)
Continuous positive airway pressure (CPAP) is a primary form of respiratory support used in the intensive care of preterm infants, but its long-term effects on airway (AW) function are unknown. We developed a neonatal mouse model of CPAP treatment to
Qingyuan Meng et al.
International journal of nanomedicine, 10, 2313-2323 (2015-04-08)
Cell culture systems have proven to be crucial for the in vitro maintenance of primary hepatocytes and the preservation of hepatic functional expression at a high level. A poly-(N-p-vinylbenzyl-4-O-β-D-galactopyranosyl-D-gluconamide) matrix can recognize cells and promote liver function in a spheroid
Claire Valotteau et al.
ACS applied materials & interfaces, 7(32), 18086-18095 (2015-08-08)
Classical antibacterial surfaces usually involve antiadhesive and/or biocidal strategies. Glycosylated surfaces are usually used to prevent biofilm formation via antiadhesive mechanisms. We report here the first example of a glycosylated surface with biocidal properties created by the covalent grafting of
Natasha R Ryz et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(9), G730-G742 (2015-09-05)
Vitamin D deficiency affects more that 1 billion people worldwide. Although thought to increase risk of bacterial infections, the importance of vitamin D on host defense against intestinal bacterial pathogens is currently unclear since injection of the active form of
Go Atsumi et al.
The Journal of general virology, 96(Pt 2), 431-439 (2014-10-30)
In this study, we identified a novel virus from gentian (Gentiana triflora) that causes ring-spots on ovaries. Furthermore, the virus causes unusual symptoms, ring-spots that appear specifically on the outer surface of the ovarian wall after pollination. Pollen grains carrying
Daniel P Morris et al.
PloS one, 10(8), e0134442-e0134442 (2015-08-06)
In mammals, increasing evidence supports mechanisms of co-transcriptional gene regulation and the generality of genetic control subsequent to RNA polymerase II (Pol II) recruitment. In this report, we use Pol II Chromatin Immunoprecipitation to investigate relationships between the mechanistic events
Paul J Toren et al.
Molecular cancer therapeutics, 14(1), 59-69 (2014-10-30)
VT-464 is a novel, nonsteroidal, small-molecule CYP17A1 inhibitor with 17,20-lyase selectivity. This study evaluates the anticancer activity of VT-464 compared with abiraterone (ABI) in castrate-resistant prostate cancer cell lines and xenograft models that are enzalutamide (ENZ)-responsive (C4-2) or ENZ-resistant (MR49C
Minjeong Jung et al.
PloS one, 10(1), e0116972-e0116972 (2015-01-28)
Autophagy is a lysosomal degradative pathway that plays an important role in maintaining cellular homeostasis. We previously showed that the inhibition of autophagy causes pancreatic β-cell apoptosis, suggesting that autophagy is a protective mechanism for the survival of pancreatic β-cells.
Sean M Hartig et al.
Molecular endocrinology (Baltimore, Md.), 29(9), 1320-1333 (2015-07-21)
Insulin resistance and type 2 diabetes mellitus (T2DM) result from an inability to efficiently store and catabolize surplus energy in adipose tissue. Subcutaneous adipocytes protect against insulin resistance and T2DM by coupling differentiation with the induction of brown fat gene
Rob J W Arts et al.
Journal of leukocyte biology, 98(1), 129-136 (2015-05-03)
Epidemiologic studies suggest that VAS has long-lasting immunomodulatory effects. We hypothesized that ATRA inhibits inflammatory cytokines in a model of trained immunity in monocytes by inducing epigenetic reprogramming through histone modifications. We used an previously described in vitro model of
Muhammad Akhtar Ali et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(25), 7743-7748 (2015-06-10)
The transcription factor ZBED6 (zinc finger, BED-type containing 6) is a repressor of IGF2 whose action impacts development, cell proliferation, and growth in placental mammals. In human colorectal cancers, IGF2 overexpression is mutually exclusive with somatic mutations in PI3K signaling
M Sato et al.
Oral diseases, 21(1), e86-e97 (2014-03-13)
Mesiodentes are usually found in the central position of the upper or lower jaw as supernumerary teeth. Here, we obtained 10 mesiodentes and three permanent teeth (PT) and separated the dental pulp (DP) from these into crown and root portions.
David Brea et al.
Scientific reports, 5, 12030-12030 (2015-07-15)
In this work, we report our study of protein expression in rat peri-infarct tissue, 48 h after the induction of permanent focal cerebral ischemia. Two proteomic approaches, gel electrophoresis with mass spectrometry and combined fractional diagonal chromatography (COFRADIC), were performed
页码 1 来自 102
页码 1 来自 102