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关键词:'200-158-2'
显示 1-15 共 15 条结果 关于 "200-158-2" 范围 论文
Sarah M Farrell et al.
Biological psychiatry, 71(6), 538-544 (2012-03-01)
Catechol-O-methyltransferase (COMT) metabolizes dopamine. The COMT Val(158)Met polymorphism influences its activity, and multiple neural correlates of this genotype on dopaminergic phenotypes, especially working memory, have been reported. COMT activity can also be regulated pharmacologically by COMT inhibitors. The inverted-U relationship
B Bruguerolle et al.
Clinical and experimental pharmacology & physiology, 21(12), 997-999 (1994-12-01)
1. This study was designed to document the acute toxicity of two metabolites of bupivacaine, desbutylbupivacaine (2,6, desbutylbupivacaine; PPX) and pipecolic acid in mice. All the compounds were administered by the intraperitoneal (i.p.) route. 2. The mean convulsant activity was
Ruo-Zhi Zhao et al.
Biochemical and biophysical research communications, 327(4), 985-992 (2005-01-18)
We investigated the effect of TNF-alpha on interleukin-8 (IL-8) and endothelin-1 (ET-1) expression, and their different signal transduction pathways. Human dermal microvascular endothelial cells (HMECs) were treated with TNF-alpha. By Northern blot analysis, TNF-alpha at 50, 100, 200, and 400
C M Loughrey et al.
Cell calcium, 34(1), 1-9 (2003-05-28)
The Ca(2+) dissociation constant (K(d)) of Fluo-3 was determined using confocal fluorescence microscopy in two different situations: (i) within the cytosol of a permeabilised cardiomyocyte; and (ii) in an intact cardiomyocyte after incubation with the acetoxymethyl ester form of Fluo-3
Qi Chang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 805(2), 275-280 (2004-05-12)
A new method for the determination of tranexamic acid (TA) in human plasma using high performance liquid chromatography with tandem mass spectrometric detection was described. TA and the internal standard, methyldopa, was extracted from a 200 l plasma sample by
George D Carystinos et al.
Molecular pharmacology, 63(4), 821-831 (2003-03-20)
Connexin 43 (Cx43) is essential for survival and is tightly regulated at the transcriptional and post-transcriptional levels. A number of previous studies have demonstrated altered expression in malignant tissues, and in the presence of carcinogenic factors. We examined the effect
D Gailani et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 8(2), 134-144 (1997-03-01)
To facilitate investigations into the physiologic and pathologic roles of factor XI, we have developed a murine model of severe factor XI deficiency using the technique of homologous recombination in embryonic stem cells. The factor XI gene was disrupted by
Inaya-Abdallah Hajj Hussein et al.
World journal of gastroenterology, 14(25), 4028-4039 (2008-07-09)
To develop a novel model of colitis in rats, using a combination of iodoacetamide and enteropathogenic E. coli (EPEC), and to elucidate the pathophysiologic processes implicated in the development of ulcerative colitis (UC). Male Sprague-Dawley rats (n = 158) were
Vildan Bozok Cetintas et al.
Endocrine, 41(3), 465-472 (2011-12-28)
Acromegaly is a syndrome that results when the pituitary gland produces excess growth hormone after epiphyseal closure at puberty. Usually, subjects with acromegaly exhibit a 2- to 3-fold higher mortality rate from diseases that are associated with cardiovascular complications when
Toshiya Kamiyama et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 45(10), E21-E31 (2014-11-11)
To evaluate the oncological implications of multiplication of α-fetoprotein (AFP) and protein induced by vitamin K absence or antagonists-II (PIVKA-II) in patients with hepatocellular carcinoma (HCC). Data were prospectively collected from 516 consecutive patients who underwent a curative primary hepatectomy
C M Goodall et al.
Journal of the National Cancer Institute, 73(5), 1215-1218 (1984-11-01)
The carcinogenic activity of N-nitrosohexamethyleneimine [(NHEX) CAS: 932-83-2; hexahydro-1-nitroso-1H-azepine] was studied in male and female mice of the four inbred strains NZB/BlGd, NZC/BlGd, NZO/BlGd, and NZY/BlGd. A total of 158 mice received NHEX treatment; 1,338 untreated controls were used, all
S Barnes et al.
Journal of neurophysiology, 68(3), 745-755 (1992-09-01)
1. Cone photoreceptors in several vertebrate species generate Ca-dependent regenerative depolarizations (e.g., Ca spikes lasting up to 2 s) in response to current injection or surround illumination and may remain in a state of prolonged depolarization (e.g., a permanent plateau
Cihangir Erem et al.
Endocrine, 36(3), 473-478 (2009-10-28)
Various abnormalities of coagulation-fibrinolytic system have been reported in patients with thyroid dysfunction. Several studies indicate that coagulation and fibrinolytic system is disturbed in the patients with hyperthyroidism. The levels of plasma thrombin-activatable fibrinolysis inhibitor (TAFI) antigen and tissue factor
S Kimura et al.
The Journal of biological chemistry, 259(17), 10705-10713 (1984-09-10)
Mouse cytochrome P1-450 and P3-450 are most closely associated with induced aryl hydrocarbon (benzo[a]pyrene) hydroxylase (EC 1.14.14.1) and acetanilide 4-hydroxylase activity, respectively. Full-length cDNA clones of P1-450 and P3-450 were generated from mRNA isolated from 3-methylcholanthrene-treated C57BL/6N mouse liver. P1-450
Jung-Ahn Lee et al.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 26(3), 360-365 (2006-05-26)
This study investigated the association between serum N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels and extracellular water (ECW%) and left ventricular (LV) dysfunction in continuous ambulatory peritoneal dialysis (CAPD) patients. The study involved 30 stable CAPD patients: 14 males, 16 females;
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