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Michael Kuncewitch et al.
Shock (Augusta, Ga.), 43(3), 268-275 (2014-12-17)
Renal ischemia-reperfusion (IR) injury (IRI) after shock states or transplantation causes tissue damage and delayed graft function, respectively. The Wnt/β-catenin signaling pathway plays a critical role in nephrogenesis. We therefore hypothesized that pharmacological activation of the Wnt/β-catenin signaling by the
Shelly R H Pecorella et al.
American journal of physiology. Lung cellular and molecular physiology, 309(8), L857-L871 (2015-07-19)
The heme oxygenase-1 (HO-1)/carbon monoxide (CO) system induces mitochondrial biogenesis, but its biological impact in human skeletal muscle is uncertain. The enzyme system generates CO, which stimulates mitochondrial proliferation in normal muscle. Here we examined whether CO breathing can be
Long Ding et al.
Molecular medicine reports, 11(6), 4431-4437 (2015-01-31)
Bile acids, which are synthesized from cholesterol in the hepatocytes of the liver, are amphipathic molecules with a steroid backbone. Studies have shown that bile acid exhibits important effects on liver regeneration. However, the mechanism underlying these effects remains unclear.
Marlene Kaposi et al.
Dalton transactions (Cambridge, England : 2003), 44(36), 15976-15983 (2015-08-19)
Amino-functionalised metal-organic frameworks UiO-66 and -67 were post-synthetically modified with salicylaldehyde. A molybdenum complex was immobilised on the resulting materials. They were characterised by (13)C-MAS-NMR, XPS and PXRD to confirm immobilisation and stability. The immobilised complex is an active and
Simon Kaja et al.
Experimental eye research, 138, 159-166 (2015-06-07)
Optic nerve head astrocytes (ONHAs) are the major glia cell type in the non-myelinated optic nerve head where they contribute critically to extracellular matrix synthesis during development and throughout life. In glaucoma, and in related disorders affecting the optic nerve
F Paradis et al.
Journal of animal science, 93(7), 3331-3341 (2015-10-07)
In beef cattle, production feedstuffs are the largest variable input cost. Beef cattle also have a large carbon footprint, raising concern about their environmental impact. Unfortunately, only a small proportion of dietary energy is directed toward protein deposition and muscle
Joseph H Banoub et al.
Rapid communications in mass spectrometry : RCM, 29(19), 1717-1732 (2015-09-04)
This study examines the electrospray ionization mass spectrometry (ESI-MS), in-source collision-induced dissociation (CID) fragmentation and low-energy collision-induced dissociation tandem mass spectrometry (CID-MS/MS) of a synthetic pair of β- and α-anomers of the amphiphilic cholesteryl polyethoxy neoglycolipids containing the 2-azido-2-deoxy-D-galactosyl-D-GalN3 moiety.
Els van Pamel et al.
Analytical and bioanalytical chemistry, 407(15), 4485-4494 (2015-03-31)
This study concerns a validated liquid chromatographic/tandem mass spectrometric (LC-MS/MS) multiresidue method for the simultaneous detection, identification, and quantitation of 15 nonsteroidal anti-inflammatory drugs (NSAIDs) in bovine meat and milk. The NSAIDs considered are carprofen, diclofenac, flufenamic acid, flunixin (5-hydroxyflunixin
Helen M Ashmead et al.
Biopolymers, 103(5), 260-270 (2014-11-25)
Proteins hold great promise in forming complex nanoscale structures which could be used in the development of new nanomaterials, devices, biosensors, electronics, and pharmaceuticals. The potential to produce nanomaterials from proteins is well supported by the numerous examples of self-assembling
Xiao Ma et al.
Molecular medicine reports, 11(2), 1228-1234 (2014-11-06)
Previous studies have suggested that hepatocyte apoptosis may be a fundamental underlying mechanism of liver injury and diseases, such as liver fibrosis. Relaxin‑3 has been reported to have anti‑fibrotic actions in the heart and to attenuate isoproterenol‑induced myocardial injury; however
Rebecca Klar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(19), 7600-7615 (2015-05-15)
Of the eight metabotropic glutamate (mGlu) receptor subtypes, only mGlu7 is expressed presynaptically at the Schaffer collateral (SC)-CA1 synapse in the hippocampus in adult animals. Coupled with the inhibitory effects of Group III mGlu receptor agonists on transmission at this
Stefan Wagner et al.
Bioorganic & medicinal chemistry, 23(12), 2839-2847 (2015-04-25)
Phosphopeptide mimetics containing the 4-phosphonocarbonyl phenylalanine (pcF) as a photo-active phosphotyrosine isoster are developed as potent, light-switchable inhibitors of the protein tyrosine phosphatase PTP1B. The photo-active inhibitors 6-10 are derived from phosphopeptide substrates and are prepared from the suitably protected
Annika Osswald et al.
PloS one, 10(6), e0128802-e0128802 (2015-06-19)
Health-promoting effects have been attributed to a number of Bifidobacterium sp. strains. These effects as well as the ability to colonise the host depend on secreted proteins. Moreover, rational design of protein secretion systems bears the potential for the generation
Agriculture: State-of-the-art soil.
Rachel Cernansky
Nature, 517(7534), 258-260 (2015-01-17)
Eva Herzog et al.
Anesthesiology, 122(2), 387-398 (2014-11-25)
Edoxaban is an oral, selective direct factor Xa inhibitor approved in Japan for venous thromboembolism prevention after orthopedic surgery. Data are lacking regarding reversal strategies for edoxaban; this study assessed whether four-factor prothrombin complex concentrate (Beriplex/Kcentra; CSL Behring GmbH, Marburg
Helle Holm Hansson et al.
Malaria journal, 14, 474-474 (2015-12-02)
Endothelial protein C receptor (EPCR) was recently identified as a key receptor for Plasmodium falciparum erythrocyte membrane protein 1 mediating sequestration of P. falciparum-infected erythrocytes in patients suffering from severe malaria. Soluble EPCR (sEPCR) inhibits binding of P. falciparum to
R Costa et al.
Chemosphere, 112, 177-184 (2014-07-23)
Understanding the inherent toxicity of water-soluble synthetic polyelectrolytes is critical for adequate risk management as well as enhancing product design when biological activity is a key performance index (e.g. for application in biofouling bivalves' control). The toxicity of two cationic
Nuray Duman et al.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 29(2), 252-257 (2014-12-11)
Current evidence suggests that nasal intermittent positive pressure ventilation (NIPPV) as a primary treatment for RDS reduces the duration of invasive mechanical ventilation (MV) comparing with nasal continuous airway pressure (NCPAP). We aimed to evaluate whether very early surfactant treatment
Jiao Li et al.
Yi chuan = Hereditas, 36(7), 697-706 (2014-07-31)
Alternative splicing (AS) in eukaryotic organisms is closely related to the gene regulation in plant abiotic stress responses, in which serine/arginine-rich proteins (SR proteins) act as key regulators. The genome sequence of maize inbred line B73 was analyzed, showing that
Simone Z Vogel et al.
Journal of immunology (Baltimore, Md. : 1950), 194(7), 3136-3146 (2015-03-10)
We previously showed that the T cell activation inhibitor, mitochondrial (Tcaim) is highly expressed in grafts of tolerance-developing transplant recipients and that the encoded protein is localized within mitochondria. In this study, we show that CD11c(+) dendritic cells (DCs), as
William A Comrie et al.
The Journal of cell biology, 208(4), 457-473 (2015-02-11)
Integrity of the dendritic cell (DC) actin cytoskeleton is essential for T cell priming, but the underlying mechanisms are poorly understood. We show that the DC F-actin network regulates the lateral mobility of intracellular cell adhesion molecule 1 (ICAM-1), but
Harun Ciftci et al.
Journal of AOAC International, 96(4), 875-879 (2013-09-05)
An analytical method for the preconcentration of nickel (Ni) and lead (Pb) in water samples on polystyrene-graft-ethylmethacrylate copolymer resin has been developed. The determinations of metal ions were performed by flame atomic absorption spectrometry. The experimental parameters, such as solution
Gopireddy Raghavender Reddy et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3458-3471 (2015-05-02)
Many different neurotransmitters and hormones control intracellular signaling by regulating the production of the second messenger cAMP. The function of the broadly expressed adenylyl cyclases (ACs) 5 and 6 is regulated by either stimulatory or inhibitory G proteins. By analyzing
Shaun A Marcott et al.
Nature, 514(7524), 616-619 (2014-10-31)
Global climate and the concentration of atmospheric carbon dioxide (CO2) are correlated over recent glacial cycles. The combination of processes responsible for a rise in atmospheric CO2 at the last glacial termination (23,000 to 9,000 years ago), however, remains uncertain. Establishing
Jenni Heidi Eveliina Mäki-Jouppila et al.
Molecular oncology, 9(6), 1056-1070 (2015-02-17)
The let-7 microRNA (miRNA) family has been implicated in the regulation of diverse cellular processes and disease pathogenesis. In cancer, loss-of-function of let-7 miRNAs has been linked to tumorigenesis via increased expression of target oncogenes. Excessive proliferation rate of tumor
Linda K Banbury et al.
Journal of ethnopharmacology, 163, 251-255 (2015-02-07)
Australian Aboriginal people used crushed leaves of Geijera parviflora Lindl. both internally and externally for pain relief, including for toothache (Cribb and Cribb, 1981). This study tested the hypothesis that this traditional use might be at least in part explained
Karsten Geletneky et al.
Comparative medicine, 65(1), 23-35 (2015-03-03)
Parvovirus H1 (H1PV) is an autonomous parvovirus that is transmitted in rodent populations. Its natural host is rats. H1PV infection is nonpathogenic except in rat and hamster fetuses and newborns. H1PV infection of human cancer cells caused strong oncolytic effects
Barbara Cwiertnia
Acta poloniae pharmaceutica, 70(4), 721-726 (2013-08-08)
Pharmaceutical aviailability of diclofenac sodium from solid dispersions of PEG 6000 have been studied in comparison to those of the corresponding physical mixtures and pure diclofenac sodium. The diclofenac sodium is poorly water soluble drug. The properties of diclofenac sodium-PEG
Michael P Trombley et al.
PloS one, 10(4), e0124373-e0124373 (2015-04-23)
Haemophilus ducreyi resists the cytotoxic effects of human antimicrobial peptides (APs), including α-defensins, β-defensins, and the cathelicidin LL-37. Resistance to LL-37, mediated by the sensitive to antimicrobial peptide (Sap) transporter, is required for H. ducreyi virulence in humans. Cationic APs
Dongxia Hou et al.
PloS one, 10(11), e0142442-e0142442 (2015-11-12)
Trophoblasts (TR) are specialized cells of the placenta and play an important role in embryo implantation. The in vitro culture of trophoblasts provided an important tool to investigate the mechanisms of implantation. In the present study, porcine trophoblast cells were
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