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Thomas G Hammond et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 387-402 (2014-06-07)
Covalent protein modifications by electrophilic acyl glucuronide (AG) metabolites are hypothetical causes of hypersensitivity reactions associated with certain carboxylate drugs. The complex rearrangements and reactivities of drug AG have been defined in great detail, and protein adducts of carboxylate drugs
Joshua O Sestak et al.
The AAPS journal, 16(6), 1185-1193 (2014-09-07)
Presentation of antigen with immune stimulating "signal" has been a cornerstone of vaccine design for decades. Here, the antigen plus immune "signal" of vaccines is modified to produce antigen-specific immunotherapies (antigen-SITs) that can potentially reprogram the immune response toward tolerance
K H Young et al.
Journal of clinical microbiology, 10(6), 852-853 (1979-12-01)
Ethyl acetate appears to be a satisfactory subsitute solvent for diethyl ether in the Formalin-ether sedimentation technique. In comparative studies, concentration of organisms with ethyl acetate was equal to or greater than that with diethyl ether. No distortion or alteration
E E Owaga et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 70, 157-162 (2014-05-21)
Lactobacilli kefiranofaciens M1 has shown novel immunomodulation and anti-allergy probiotic attributes in cell and animal models. An acute oral toxicity assessment of L. kefiranofaciens M1 was evaluated in Sprague-Dawley rats. The rats were randomly assigned to four groups (12 rats/sex/group):
Vaibhav Khare et al.
International journal of pharmaceutics, 470(1-2), 51-62 (2014-05-09)
Gemcitabine, a nucleoside analogue, is used in the treatment of various solid tumors, however, its efficacy is limited by rapid metabolism by cytidine deaminase and fast kidney excretion. In this study, a polymeric conjugate of gemcitabine was prepared by covalent
Borislav Kovačević et al.
Journal of the American Society for Mass Spectrometry, 25(11), 1974-1986 (2014-09-10)
This study presents a detailed experimental investigation of charge isomers of protonated 4-quinolone antibiotics molecules formed during electrospray ionization (ESI) with proposed dissociation mechanisms after collisional activation. Piperazinyl quinolones have been previously shown to exhibit erratic behavior during tandem MS
P. A. Wilhite and the discovery of ether anesthesia.
Wilson C Wilhite
Bulletin of anesthesia history, 29(4), 53-54 (2012-08-02)
Romina Vitale et al.
ChemMedChem, 9(2), 323-336 (2014-01-10)
N-Acylethanolamine acid amidase (NAAA) is a cysteine amidase that preferentially hydrolyzes saturated or monounsaturated fatty acid ethanolamides (FAEs), such as palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), which are endogenous agonists of nuclear peroxisome proliferator-activated receptor-α (PPAR-α). Compounds that feature an α-amino-β-lactone
Theunis T Cloete et al.
Bioorganic chemistry, 46, 10-16 (2012-12-19)
A series of n-alkyl/aryl esters were synthesized and their in vitro antiplasmodial activity was measured alongside that of previously synthesized aminoethylethers of artemisinin ozonides against various strains of Plasmodium falciparum. The cytotoxicity against human cell lines was also assessed. The
Huma Syed et al.
Molecular medicine reports, 12(5), 7649-7656 (2015-09-24)
Cyclooxygenase (COX) enzymes are expressed in the brain; however, their role in hippocampus-dependent and cortex-dependent cognitive functions remains to be fully elucidated. The aim of the present study was to comparatively investigate the effects of piroxicam, a selective COX-I inhibitor
Kelly M Mabry et al.
Biomaterials, 74, 31-41 (2015-10-05)
Valvular interstitial cells (VICs) actively maintain and repair heart valve tissue; however, persistent activation of VICs to a myofibroblast phenotype can lead to aortic stenosis. To better understand and quantify how microenvironmental cues influence VIC phenotype and myofibroblast activation, we
Shannon L Haughney et al.
Nanoscale, 6(22), 13770-13778 (2014-10-07)
Acute respiratory infections represent a significant portion of global morbidity and mortality annually. There is a critical need for efficacious vaccines against respiratory pathogens. To vaccinate against respiratory disease, pulmonary delivery is an attractive route because it mimics the route
Khaled A Osman
Journal of AOAC International, 98(5), 1199-1206 (2015-11-04)
Organochlorine residues were detected in 54/200 of muscles and 55/200 of livers of camels slaughtered in different districts of Al-Qassim region, Saudi Arabia, by using GC/MS analysis. The ΣDDT residues (Σ-DDT=p,p'-DDT+p,p'-DDE+p,p'-DDD+p,p'-DDA) in muscles and livers were the most frequent. The
Adrianne M Rosales et al.
Biomacromolecules, 16(3), 798-806 (2015-01-30)
The elastic modulus of the extracellular matrix is a dynamic property that changes during various biological processes, such as disease progression or wound healing. Most cell culture platforms, however, have traditionally exhibited static properties, making it necessary to replate cells
Monika Gibis et al.
Journal of food science, 80(11), C2430-C2439 (2015-10-08)
The impact of precursors such as creatine, creatinine, and glucose on the formation of mutagenic/carcinogenic heterocyclic amines (HAs) were studied in patties of 9 different animal species equally heat treated with a double-plate contact grill. All grilled patties of the
Xinxia Wang et al.
PloS one, 10(3), e0122028-e0122028 (2015-04-01)
Obesity may result from altered fatty acid (FA) disposal. Altered FA distribution in obese individuals is poorly understood. Lean wild-type C57BL/6J and obese C57BL/6Job/ob mice received an oral dose of [1-(14)C]18:1n-9 (oleic acid), and the radioactivity in tissues was evaluated
Shaoqing Cui et al.
Journal of pharmaceutical and biomedical analysis, 102, 64-77 (2014-09-23)
Aroma profiles of ginseng samples at different ages were investigated using electronic nose (E-nose) and GC-MS techniques combined with chemometrics analysis. The bioactive ginsenoside and volatile oil content increased with age. E-nose performed well in the qualitative analyses. Both Principal
Meher Kanta Gupta et al.
Materials science & engineering. C, Materials for biological applications, 58, 852-862 (2015-10-20)
Drug encapsulated nanocarriers are vehicles to transport the drug molecules and release them at the immediate vicinity of the diseased sites. The aim of this study was to design poly (2-hydroxyethyl methacrylate) nanoparticles (PHEMANPs) as a swelling and diffusion controlled
Kanako Moriyama et al.
Laboratory investigation; a journal of technical methods and pathology, 94(11), 1200-1211 (2014-09-30)
Galectins are a unique family of lectins bearing one or two carbohydrate recognition domains (CRDs) that have the ability to bind molecules with β-galactoside-containing carbohydrates. It has been shown that galectins regulate not only cell growth and differentiation but also
Dahae Lim et al.
Journal of ethnopharmacology, 160, 41-51 (2014-12-06)
Stemona tuberosa (ST) is a traditional herbal medicine used for the treatment of various respiratory diseases in eastern Asia. We investigated the anti-inflammatory effects of a ST water extract in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and in cigarette smoke (CS)-induced
Abdel-Majeed A Safer et al.
Journal of nanoscience and nanotechnology, 15(9), 6452-6459 (2015-12-31)
The present study examined the effect of Green Tea Extract (GTE) encapsulated into Chitosan Nanoparticles (CS-NPs) on hepatic fibrosis in rat model as determined by atomic force microscopy (AFM). The bioactive compounds in GTE encapsulated into CS-NPs were determined using
Alessandro Mariani et al.
Developmental neurobiology, 75(1), 23-38 (2014-07-22)
The central nervous system (CNS) is extremely vulnerable to the toxic effects of environmental pollutants during development. Polybrominated diphenyl ethers (PBDEs) are persistent contaminants, increasingly present in the environment and in human tissues. Recent investigations identified a correlation between maternal
Hiroharu Saito et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 23(11), 2401-2409 (2014-06-06)
Some antidepressants are effective for treating neuropathic pain independent of any effect on depression. Selective serotonin reuptake inhibitors (SSRIs) are one of the potential agents to treat neuropathic pain. The aims of this study were to compare the effects of
Martin Fischnaller et al.
Food chemistry, 194, 149-155 (2015-10-17)
A simple solid-phase extraction method for the enrichment of 5 bisphenol derivatives using hexagonal boron nitride (BN) was developed. BN was applied to concentrate bisphenol derivatives in spiked water samples and the compounds were analyzed using HPLC coupled to fluorescence
Hyeong Jun Lim et al.
Physical chemistry chemical physics : PCCP, 16(33), 17466-17472 (2014-07-16)
The Hansen solubility parameters (HSPs) of as-produced multi-walled carbon nanotubes (APMWCNTs) were determined by means of the inverse gas chromatography (IGC) technique. Due to non-homogeneous surfaces of the APMWCNTs arising from defects and impurities, it was necessary to establish adequate
Philippe Collery et al.
Anticancer research, 34(4), 1679-1689 (2014-04-03)
We proposed a new water-soluble rhenium diseleno-ether compound (with one atom of Re and two atoms of Se) and investigated the uptake of Re into the nucleus of malignant cells in culture exposed to the compound for 48 h and
Shirin Tavakoli et al.
Journal of liposome research, 25(1), 67-77 (2014-06-25)
Stealth liposomes encapsulating oligonucleotides are considered as promising non-viral gene delivery carriers; however, general preparation procedures are not capable to encapsulate nucleic acids (NAs) efficiently. In this study, the lyophobic complexes of deoxythymidine20 oligonucleotide (dT20) and DOTAP were used instead
Dong Luo et al.
Pflugers Archiv : European journal of physiology, 467(4), 641-649 (2014-06-07)
Insulin sensitivity is decreased by prostaglandin E2 (PGE2), a major product of cyclooxygenase (COX). As shown in erythrocytes, PGE2 formation is inhibited by annexin A7. The present study defined the role of annexin A7 in glucose metabolism. Gene-targeted mice lacking
Wan Mohd Nuzul Hakimi Wan Salleh et al.
Archives of pharmacal research, 38(4), 485-493 (2014-08-08)
The present study aimed to examine the chemical compositions of the essential oils of Beilschmiedia madang and their antioxidant, antibacterial, antifungal, anticholinesterase and anti-tyrosinase activities. The major constituents of the essential oils of leaf and bark of B. madang were
Nurcan Değirmencioğlu et al.
Food chemistry, 194, 587-594 (2015-10-17)
In this study, the changes in phenolic composition, total phenolic content, and antioxidant capacity of tarhanas supplemented with oat flour (OF) at the levels of 20-100% (w/w) after three drying treatments (sun-, oven-, and microwave drying) were investigated. A total
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