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Matej Adámik et al.
Biochemical and biophysical research communications, 456(1), 29-34 (2014-12-03)
Site-specific DNA recognition and binding activity belong to common attributes of all three members of tumor suppressor p53 family proteins: p53, p63 and p73. It was previously shown that heavy metals can affect p53 conformation, sequence-specific binding and suppress p53...
Dennis J Paustenbach et al.
Clinical toxicology (Philadelphia, Pa.), 52(2), 98-112 (2013-11-22)
INTRODUCTION. There has been some recent concern regarding possible systemic health effects resulting from elevated blood cobalt concentrations in patients with cobalt containing hip implants. To date there are no blood cobalt criteria to help guide physicians when evaluating an...
William T Eckenhoff et al.
Biochimica et biophysica acta, 1827(8-9), 958-973 (2013-05-22)
The generation of H2 from protons and electrons by complexes of cobalt has an extensive history. During the past decade, interest in this subject has increased as a result of developments in hydrogen generation that are driven electrochemically or photochemically....
Duy Duc Nguyen et al.
Biochemical and biophysical research communications, 447(1), 101-107 (2014-04-08)
The peptidases in clan MH are known as cocatalytic zinc peptidases that have two zinc ions in the active site, but their metal preference has not been rigorously investigated. In this study, the molecular basis for metal preference is provided...
Marilda Helena Toledo Brandão et al.
Anais brasileiros de dermatologia, 87(2), 269-276 (2012-05-10)
Metals, especially nickel, are the most common contact allergens in children. Recent data has shown increased incidence of allergy in industrialized countries. Sensitization can occur at any age, even in neonates. Costume jewelry, particularly earrings, is linked to increased sensitization...
O M Vasyliv et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 75(2), 37-44 (2013-06-01)
Superoxide dismutase, as one of the enzymes of cells' antioxidant defensive system, catalyzes superoxide anion-radical (O2-) dismutation with O2 and H2O2 forming. The influence of such transition metal compounds, as FeSO4, FeCl3, MnCl2, NiCl2, and CoCl2 on superoxide dismutase activity...
Ji-Yun Seon et al.
Journal of nanoscience and nanotechnology, 13(11), 7540-7545 (2013-11-20)
A dielectophoretic (DEP) device fabricated by a conventional low temperature co-fired ceramic (LTCC) process, for manipulating micro and nanostructure materials, such as spherical polystyrene microspheres, titanium dioxide (TiO2) nanotubes, and silver (Ag) nanowires, is described. To generate a non-uniform electric...
Marta Fort et al.
Environmental research, 136, 148-154 (2014-12-03)
Cobalt is an essential trace element but may cause toxic effects upon occupational or environmental exposure. Women accumulate more cobalt than men at similar exposure levels which may be related to higher metabolic iron loss. During pregnancy these losses are...
G Toncev et al.
European journal of neurology, 9(3), 221-226 (2002-05-03)
Several findings suggest lower levels of serum uric acid in multiple sclerosis (MS) patients. The aim of this study is to investigate relationships of uric acid serum levels in relapse-remitting (RR) MS patients with clinical activity of disease and blood-brain...
Goran Gajski et al.
Biochimica et biophysica acta, 1840(1), 565-576 (2013-10-22)
The main objective of the present study was to investigate chemical composition and possible cyto/genotoxic potential of several medical implant materials commonly used in total hip joint replacement. Medical implant metal alloy (Ti6Al4V and CoCrMo) and high density polyethylene particles...
Ryota Shizu et al.
Toxicology letters, 219(2), 143-150 (2013-03-27)
Hypoxia inducible factor (HIF) and 5'-AMP-activated protein kinase are often activated under similar physiological conditions. Constitutive androstane receptor (CAR) translocates into the nucleus in accordance with 5'-AMP-activated protein kinase and thus confers transactivation. The aim of the present study was...
Faiz U Ahmad et al.
Journal of neurosurgery. Spine, 19(5), 629-636 (2013-09-24)
Cobalt-chromium alloy (CoCr) rods haves some preferred biomechanical properties over titanium rods for spinal fixation. The use of CoCr rods in spinal fusion is relatively new, and there is no study in the existing world literature assessing the artifact caused...
Giovanni Forte et al.
Annali dell'Istituto superiore di sanita, 41(2), 213-216 (2005-10-26)
Although some studies suggested a link between exposure to trace elements and development of multiple sclerosis (MS), clear information on their role in the aetiology of MS is still lacking. In this study the concentrations of Al, Ba, Be, Bi...
S Perconti et al.
Journal of biological regulators and homeostatic agents, 27(2), 443-454 (2013-07-09)
Size-dependent characteristics of novel engineered nanomaterials might result in unforeseen biological responses and toxicity. To address this issue, we used cDNA microarray analysis (13443 genes) coupled with bioinformatics and functional gene annotation studies to investigate the transcriptional profiles of Balb/3T3...
V Calabrese et al.
Neurochemical research, 28(9), 1321-1328 (2003-08-27)
Recent studies suggest that NO and its reactive derivative peroxynitrite are implicated in the pathogenesis of multiple sclerosis (MS). Patients dying with MS demonstrate increased astrocytic inducible nitric oxide synthase activity, as well as increased levels of iNOS mRNA. Peroxynitrite...
K J Bär et al.
Neurobiology of aging, 24(2), 333-338 (2002-12-25)
Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of...
M Naoi et al.
Mechanisms of ageing and development, 111(2-3), 175-188 (2000-02-03)
Dopamine neurons in the substantia nigra of human brain are selectively vulnerable and the number decline by aging at 5-10% per decade. Enzymatic and non-enzymatic oxidation of dopamine generates reactive oxygen species, which induces apoptotic cell death in dopamine neurons....
Beatrice Bocca et al.
Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <...
Max R Friedfeld et al.
Science (New York, N.Y.), 342(6162), 1076-1080 (2013-11-30)
Asymmetric hydrogenation of alkenes is one of the most widely used methods for the preparation of single enantiomer compounds, especially in the pharmaceutical and agrochemical industries. For more than four decades, precious metal complexes containing rhodium, iridium, and ruthenium have...
Jonathon R Campbell et al.
Clinical chemistry and laboratory medicine, 51(1), 213-220 (2012-10-02)
Individuals with advanced hip disease suffer from pain, impaired hip function, and decreased quality of life. Roughly one million metal-on-metal (MoM) hip prostheses have been implanted worldwide in order to ameliorate these issues. While most MoM hip replacements are successful...
Marieke A Dijkman et al.
Nederlands tijdschrift voor geneeskunde, 156(42), A4983-A4983 (2012-10-19)
Since 2011, cobalt and chromium blood levels are measured in patients with a metal-on-metal hip implant (MoM prosthesis). In this article we discuss the health risks that are related to chronically elevated blood cobalt concentrations induced by abnormal wear and...
Lichao Hou et al.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 32(1), 41-51 (2013-06-14)
Tungsten carbide-cobalt (WC-Co) nanoparticle composites have wide applications because of their hardness and toughness. WC-Co was classified as "probably carcinogenic" to humans by the International Agency for Research on Cancer (IARC) in 2003. It is believed that the toxicity and...
Richard Lass et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(9), 1234-1240 (2014-05-21)
Diagnosis of adverse reactions to metal debris in metal-on-metal hip arthroplasty is a multifactorial process. Systemic ion levels are just one factor in the evaluation and should not be relied upon solely to determine the need for revision surgery. Furthermore...
Feiran Zhang et al.
Journal of medicinal chemistry, 56(10), 3996-4016 (2013-05-03)
Methionine aminopeptidases (MetAPs), which remove the initiator methionine from nascent peptides, are essential in all organisms. While MetAP2 has been demonstrated to be a therapeutic target for inhibiting angiogenesis in mammals, MetAP1 seems to be vital for cell proliferation. Our...
S Carbajo-Pescador et al.
British journal of cancer, 109(1), 83-91 (2013-06-13)
Hepatocellular carcinoma (HCC) growth relies on angiogenesis via vascular endothelial growth factor (VEGF) release. Hypoxia within tumour environment leads to intracellular stabilisation of hypoxia inducible factor 1 alpha (Hif1α) and signal transducer and activator of transcription (STAT3). Melatonin induces apoptosis...
Chemistry. Abundant metals give precious hydrogenation performance.
R Morris Bullock
Science (New York, N.Y.), 342(6162), 1054-1055 (2013-11-30)
R H Kadam et al.
Journal of nanoscience and nanotechnology, 14(6), 4101-4107 (2014-04-18)
Ferrite samples with a chemical formula Co0.5Ni0.5Al(x)Fe(2-x)O4 (where x = 0.0, 0.25, 0.5, 0.75 and 1.0) were synthesized by sol-gel auto-combustion method. The synthesized samples were annealed at 600 degrees C for 4 h. An analysis of X-ray diffraction (XRD)...
Lauren Nozomi Marques Yabuki et al.
Environmental monitoring and assessment, 186(2), 961-969 (2013-09-21)
Studies concerning the lability and bioavailability of trace metals have played a prominent role in the search for contamination of water resources. This work describes the first application yet of the diffusive gradients in thin films technique (DGT) to the...
George Psomas et al.
Dalton transactions (Cambridge, England : 2003), 42(18), 6252-6276 (2013-03-27)
The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are...
Ivan G Pallares et al.
Biochemistry, 53(50), 7969-7982 (2014-11-26)
CobA from Salmonella enterica (SeCobA) is a member of the family of ATP:Co(I)rrinoid adenosyltransferase (ACAT) enzymes that participate in the biosynthesis of adenosylcobalamin by catalyzing the transfer of the adenosyl group from an ATP molecule to a reactive Co(I)rrinoid species...
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