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Shufan Ge et al.
Journal of agricultural and food chemistry, 63(11), 2902-2910 (2015-02-27)
Chrysin, a flavone found in many plants, is also available as a dietary supplement because of its reported anticancer activities. However, its bioavailability is very poor due to extensive phase II metabolism. The purpose of this study was to develop
Luís R Silva et al.
Asian Pacific journal of tropical medicine, 8(11), 889-897 (2015-11-29)
To improve the knowledge on the metabolite composition of Endopleura uchi bark, concerning phenolic compounds, and to evaluate some of its biological capacities for further possible exploitation in food and pharmaceutical industries associated to their health-promoting qualities. Two different extracts
Wilfried Jonkers et al.
PLoS genetics, 10(11), e1004783-e1004783 (2014-11-21)
Cell fusion in genetically identical Neurospora crassa germlings and in hyphae is a highly regulated process involving the activation of a conserved MAP kinase cascade that includes NRC-1, MEK-2 and MAK-2. During chemotrophic growth in germlings, the MAP kinase cascade
Pauline M Snijder et al.
Nitric oxide : biology and chemistry, 42, 87-98 (2014-12-03)
Hypertension and proteinuria are important mediators of renal damage. Despite therapeutic interventions, the number of patients with end stage renal disease steadily increases. Hydrogen sulfide (H(2)S) is an endogenously produced gasotransmitter with vasodilatory, anti-inflammatory and antioxidant properties. These beneficial characteristics
Zhuo Qu et al.
Journal of ethnopharmacology, 155(1), 203-212 (2014-06-15)
Wei-Chang-An pill (WCA pill), a traditional Chinese medicine, has been used for treating various gastrointestinal diseases for several decades. Despite the popular medicinal use of WCA pill, less data was available to its activity and mechanism in gastrointestinal disorders. To
Annette R Rowe et al.
Applied microbiology and biotechnology, 99(5), 2313-2327 (2014-12-04)
To better understand the quantitative relationships between messenger RNA (mRNA) and protein biomarkers relevant to bioremediation, we quantified and compared respiration-associated gene products in an anaerobic syntrophic community. Respiration biomarkers for Dehalococcoides, an organohalide reducer, and Methanospirillum, a hydrogenotrophic methanogen
Raquel Garcia et al.
Journal of separation science, 38(7), 1204-1212 (2015-02-07)
Aiming to implement an analytical methodology that is highly selective for the extraction and quantification of terbuthylazine from olive oil, we successfully achieved: (i) the development of a molecularly imprinted polymer by bulk polymerization using terbuthylazine as template molecule, methacrylic
Aihua Zhang et al.
Food & function, 6(11), 3540-3549 (2015-08-25)
Limonin has been found to possess significant anti-inflammatory properties in animal tests and with, human cells, however, its precise metabolism mechanism has not been well explored. The aim of this study was to investigate the anti-inflammatory effects of limonin in
Fazli Nasir et al.
Drug development and industrial pharmacy, 40(11), 1503-1508 (2013-08-30)
The objective of the current work was to develop and evaluate thermoreversible subcutaneous drug delivery system for Insulin. Thermoreversible in-situ gel system was developed and evaluated both in-vitro and in-vivo comprising of pluronic F-127 alone or in combination with methylcellulose
Jiake He et al.
Molecular pharmaceutics, 11(8), 2745-2754 (2014-06-25)
A novel positron emission tomography (PET) tracer, [(11)C]-rosuvastatin (RSV), was developed to dynamically and noninvasively measure hepatobiliary transport and tissue distribution of [(11)C]-RSV in rats. Male Sprague-Dawley rats were administered either an Oatp inhibitor, rifampin (RIF, 40 mg/kg iv bolus
Wenping Tang et al.
Journal of agricultural and food chemistry, 63(44), 9722-9728 (2015-10-23)
The hepatoprotective activities of two different extracts, a hydroethanolic crude bulb extract (CB) and a steroidal glycoside-rich 1-butanol extract (BuOH), prepared from the bulbs of Easter lily (Lilium longiflorum Thunb.), were evaluated in a 24 week study in the female
C A Ledesma-Escobar et al.
Journal of mass spectrometry : JMS, 50(11), 1196-1205 (2015-10-28)
Eighty four metabolites (32 flavonoids, 15 amino acids, nine carboxylic acids, six coumarins, six sugars, five phenolic acids and 11 unclassified compounds) have been tentatively identified in a polar extract from lemon, without reference standards, based on their liquid chromatography-quadrupole-time-of-flight
Hongbin Liu et al.
Journal of pharmaceutical and biomedical analysis, 109, 142-149 (2015-03-17)
RP-HPLC has been demonstrated as a powerful tool to study antibody free thiol and disulfide variants. Recently, the introduction of UHPLC columns with wide pore size (300Å) and small particle size (1.7μm) offered the opportunity to further improve the separation
Matthias Schwebe et al.
Biochemical pharmacology, 94(2), 109-129 (2015-02-11)
The clinical efficiency of the highly potent antitumor agent doxorubicin is limited by cardiotoxic effects. In a murine doxorubicin cardiotoxicity model, increased endothelin-1 (ET-1) expression and cardioprotective effects of the dual ET-1 blocker bosentan were demonstrated. To date it is
Libo Zhao et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1004, 37-45 (2015-10-08)
Penehyclidine hydrochloride (PHC) is an anticholinergic drug with both antimuscarinic and antinicotinic activity. In order to compare the pharmacokinetics of two administration routes (intravenous injection (i.v.) and intramuscular injection (i.m.)) of PHC, an improved High Performance Liquid Chromatography Tandem Mass
B Gómara et al.
Journal of chromatography. A, 1423, 86-95 (2015-11-11)
The retention behavior of nine MPAEs has been studied, using commercial LC columns with octadecylsilane (ODS), phenyl, and amide-type SPs. First, it was found that the use of methanol in the mobile phase is not advisable, because induce a transesterification
Leland L Black et al.
Journal of immunology (Baltimore, Md. : 1950), 195(10), 4685-4698 (2015-10-16)
Apolipoprotein (Apo)A-I, the major lipid-binding protein of high-density lipoprotein, can prevent autoimmunity and suppress inflammation in hypercholesterolemic mice by attenuating lymphocyte cholesterol accumulation and removing tissue-oxidized lipids. However, whether ApoA-I mediates immune-suppressive or anti-inflammatory effects under normocholesterolemic conditions and the
Martine Cao et al.
Pharmacological research, 100, 135-147 (2015-08-05)
Two new analogues of CDDO-Imidazolide (CDDO-Im), namely 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4(-pyridin-2-yl)-1H-imidazole ("CDDO-2P-Im") and 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4(-pyridin-3-yl)-1H-imidazole ("CDDO-3P-Im") have been synthesized and tested for their potential use as chemopreventive drugs. At nanomolar concentrations, they were equipotent to CDDO-Im for inducing differentiation and apoptosis in U937 leukemia
Michael P Torrens-Spence et al.
Phytochemistry, 106, 37-43 (2014-08-12)
Plant aromatic amino acid decarboxylases (AAADs) catalyze the decarboxylation of aromatic amino acids with either benzene or indole rings. Because the substrate selectivity of AAADs is intimately related to their physiological functions, primary sequence data and their differentiation could provide
C F Massaro et al.
Fitoterapia, 95, 247-257 (2014-04-08)
Propolis of Australian stingless bees (Tetragonula carbonaria, Meliponini) originating from Corymbia torelliana (Myrtaceae) fruit resins was tested for its antimicrobial activities as well as its flavonoid contents. This study aimed at the isolation, structural elucidation and antibacterial testing of flavanones
Shu Jiang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 27-32 (2014-07-01)
Scutellaria-coptis herb couple is widely used traditional Chinese medicine (TCM) in treating type 2 diabetes; however, the in vivo integrated metabolism of its main bioactive components in type 2 diabetic rats remains unknown. In this paper, ultra-performance liquid chromatography (UPLC)
István Ilisz et al.
Journal of chromatography. A, 1363, 169-177 (2014-07-20)
Two chiral stationary phases containing a quinine- or a quinidine-based zwitterionic ion-exchanger as chiral selector were applied for the enantioseparation of 27 unusual cyclic secondary α-amino acids. The effects of the nature and concentration of the bulk solvent, the acid
Elisa A Nickum et al.
Journal of chromatographic science, 53(1), 38-46 (2014-03-29)
A considerable number of erectile dysfunction products, and dietary supplements suspected of containing phosphodiesterase-5 (PDE-5) inhibitors, have been analyzed by the US Food and Drug Administration. Often these samples are found to contain the approved active pharmaceutical ingredients (APIs) such
Changtao Jiang et al.
The Journal of clinical investigation, 125(1), 386-402 (2014-12-17)
Nonalcoholic fatty liver disease (NAFLD) is a major worldwide health problem. Recent studies suggest that the gut microbiota influences NAFLD pathogenesis. Here, a murine model of high-fat diet-induced (HFD-induced) NAFLD was used, and the effects of alterations in the gut
M M F Queiroz et al.
Phytochemical analysis : PCA, 26(3), 183-188 (2015-01-27)
Tetrapterys mucronata Cav. (Malpighiaceae) is a plant used in some regions of Brazil in the preparation of ayahuasca. To determine the content of the main tryptamine alkaloids in the stem bark of T. mucronata Cav. and assess their possible toxic
Ivan Sanchez-De Melo et al.
Journal of proteomics, 127(Pt B), 225-233 (2015-04-25)
The pharmaceutical market has entered an era in which the production of new therapeutics is being often replaced by "biosimilars", copies of already commercialized products waiting for the patents to expire in order to be distributed in a more competitive
Ewa Radzikowska et al.
Organic & biomolecular chemistry, 13(1), 269-276 (2014-11-05)
Chimeric oligonucleotides containing phosphodiester and phosphorothioate linkages have been obtained using the solid phase synthesis. The oligonucleotide parts possessing natural internucleotide phosphate bonds were assembled using commercially available nucleoside 3'-O-(2-cyanoethyl-N,N-diisopropylamino)phosphoramidites 7 whereas the phosphorothioate segment was built using nucleoside 3'-O-(2-thio-1,3,2-oxathiaphospholanes)
R Buchi Reddy et al.
Journal of pharmaceutical and biomedical analysis, 117, 104-108 (2015-09-08)
A new unknown impurity was observed in accelerated stability studies of Metoprolol tartrate tablets. This impurity has been identified, synthesized and characterized through different spectral studies and confirmed as an adduct of lactose and Metoprolol formed by Maillard reaction.
Kyeong-Hwa Seo et al.
Journal of medicinal food, 18(4), 403-408 (2014-12-17)
A prenylated arylbenzofuran and six flavonoids were isolated from the fruits of Morus alba L. through silica gel, octadecyl silica gel, and Diaion HP-20 column chromatography. Based on the nuclear magnetic resonance, mass spectrometry, and infrared spectroscopic data, the chemical
Ana Masiá et al.
Journal of chromatography. A, 1378, 19-31 (2015-01-13)
Pressurized liquid extraction (PLE) and Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) extraction methods were optimized for the simultaneous determination of 50 pesticides in sediment, soils and sewage sludge. For QuEChERS development, several buffers and dispersive solid-phase extraction clean-up
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