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Makoto Fukuta et al.
PloS one, 9(12), e112291-e112291 (2014-12-03)
Neural crest cells (NCCs) are an embryonic migratory cell population with the ability to differentiate into a wide variety of cell types that contribute to the craniofacial skeleton, cornea, peripheral nervous system, and skin pigmentation. This ability suggests the promising
Karen M Chisholm et al.
The American journal of surgical pathology, 39(3), 294-303 (2015-01-13)
MYC translocations are a defining feature of Burkitt lymphoma and a group of diffuse large B-cell lymphoma (DLBCL) with inferior outcome. However, the clinical relevance of MYC gene rearrangement and its relationship with MYC protein expression has not been well
Raymond D Hickey et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 21(4), 442-453 (2014-12-09)
Cell transplantation is a potential treatment for the many liver disorders that are currently only curable by organ transplantation. However, one of the major limitations of hepatocyte (HC) transplantation is an inability to monitor cells longitudinally after injection. We hypothesized
Tae Hyung Kim et al.
Biochimica et biophysica acta, 1850(2), 401-410 (2014-12-03)
Psammaplin A (PsA) is a natural product isolated from marine sponges, which has been demonstrated to have anticancer activity against several human cancer cell lines via the induction of cell cycle arrest and apoptosis. New drugs that are less toxic
Somayeh Ezzatpanah et al.
Pharmacology, biochemistry, and behavior, 129, 105-110 (2015-01-07)
Electrical and chemical stimulation of the lateral hypothalamus (LH) produces analgesia. Previous studies emphasized the importance of LH in the modulation of nociceptive behaviors in the acute pain models. In the current study, for the first time, we examined the
Jeremy S Toma et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(3), 1291-1306 (2015-01-23)
Induced pluripotent cell-derived motoneurons (iPSCMNs) are sought for use in cell replacement therapies and treatment strategies for motoneuron diseases such as amyotrophic lateral sclerosis (ALS). However, much remains unknown about the physiological properties of iPSCMNs and how they compare with
Thomas S Lisse et al.
Molecular endocrinology (Baltimore, Md.), 28(10), 1698-1706 (2014-09-03)
Alopecia (hair loss) in vitamin D receptor (VDR)-null mice is due to absence of ligand-independent actions of the VDR that are required for initiation of postmorphogenic hair cycles. Investigations were undertaken to determine whether the VDR is required for the
Philipp Petermann et al.
Journal of virology, 89(1), 262-274 (2014-10-17)
Skin keratinocytes represent a primary entry site for herpes simplex virus 1 (HSV-1) in vivo. The cellular proteins nectin-1 and herpesvirus entry mediator (HVEM) act as efficient receptors for both serotypes of HSV and are sufficient for disease development mediated
R M E McKenzie et al.
Molecular oral microbiology, 30(2), 111-127 (2014-07-25)
The adaptability and survival of Porphyromonas gingivalis in the oxidative microenvironment of the periodontal pocket are indispensable for survival and virulence, and are modulated by multiple systems. Among the various genes involved in P. gingivalis oxidative stress resistance, vimA gene
Jocelyn Turpin et al.
Journal of virology, 89(2), 931-951 (2014-10-31)
Human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 encode auxiliary proteins that play important roles in viral replication, viral latency, and immune escape. The presence of auxiliary protein-encoding open reading frames (ORFs) in HTLV-3, the latest HTLV to be
Christopher R Cogle et al.
Leukemia, 28(10), 1978-1987 (2014-03-19)
Vascular endothelial cells are a critical component of the hematopoietic microenvironment that regulates blood cell production. Recent studies suggest the existence of functional cross-talk between hematologic malignancies and vascular endothelium. Here we show that human acute myeloid leukemia (AML) localizes
Harry Karmouty-Quintana et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(1), 50-60 (2014-10-17)
Idiopathic pulmonary fibrosis (IPF) is a lethal, fibroproliferative disease. Pulmonary hypertension (PH) can develop secondary to IPF and increase mortality. Alternatively, activated macrophages (AAMs) contribute to the pathogenesis of both IPF and PH. Here we hypothesized that adenosine signaling through
Yi-Qin Wang et al.
American journal of cancer research, 5(1), 255-266 (2015-01-30)
Dysregulation of BCL6 plays critical oncogenic roles and facilitates tumorigenesis in various malignancies. However, whether the aberrant expression of BCL6 in ovarian carcinoma is associated with malignancy, metastasis or prognosis remains unknown. Our study aimed to investigate the expression of
Tatsunari Sasada et al.
Breast cancer (Tokyo, Japan), 21(5), 571-575 (2013-01-12)
Axillary lymph node dissection (ALND) is the standard procedure for breast cancer with sentinel lymph node (SLN) metastasis. However, additional nodal metastasis is occasionally detected (<40 % cases) during complete ALND in patients with SLN metastasis. Several models have been developed
Chi-Hsien Liu et al.
Chemical & pharmaceutical bulletin, 63(2), 59-67 (2015-03-10)
Lutein is a macular pigment that contributes to maintaining eye health. The development of lutein-laden nanocarriers for ocular delivery would have the advantages of user friendliness and cost-effectiveness. Nano-scaled vehicles such as cyclodextrin (CD) and nanoemulsion could overcome the barriers
William A Pastor et al.
Nature communications, 5, 5795-5795 (2014-12-17)
The Microrchidia (Morc) family of GHKL ATPases are present in a wide variety of prokaryotic and eukaryotic organisms but are of largely unknown function. Genetic screens in Arabidopsis thaliana have identified Morc genes as important repressors of transposons and other
Yifei Wang et al.
International journal of oncology, 46(5), 1924-1934 (2015-03-18)
Cranberry flavonoids (flavonols and flavan-3-ols), in addition to their antioxidant properties, have been shown to possess potential in vitro activity against several cancers. However, the difficulty of isolating cranberry compounds has largely limited anticancer research to crude fractions without well-defined
Vincent Vanoosthuyse et al.
PLoS genetics, 10(6), e1004415-e1004415 (2014-06-20)
Functional links connecting gene transcription and condensin-mediated chromosome condensation have been established in species ranging from prokaryotes to vertebrates. However, the exact nature of these links remains misunderstood. Here we show in fission yeast that the 3' end RNA processing
Maximilian Larena et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3829-3839 (2015-03-20)
We have examined the molecular pathways involved in the adjuvant action of cholera toxin (CT) and two novel nontoxic molecules, multiple-mutated CT (mmCT) and double-mutant heat-labile toxin (dmLT) on human T cell responses. Human PBMCs or isolated monocytes were stimulated
Abbey P Theiss et al.
PloS one, 9(11), e113608-e113608 (2014-11-20)
Phosphorylated signaling molecules are biomarkers of cancer pathophysiology and resistance to therapy, but because phosphoprotein analytes are often labile, poorly controlled clinical laboratory practices could prevent translation of research findings in this area from the bench to the bedside. We
Jose Flavio A de Almeida et al.
Tissue engineering. Part A, 20(23-24), 3089-3100 (2014-05-20)
Regenerative endodontic procedures have become a valuable alternative for the treatment of immature teeth with pulp necrosis. In addition to resolution of periradicular pathosis and promotion of continued root development, positive vitality testing has been observed in some regenerative clinical
Matthew I Bury et al.
Biomaterials, 35(34), 9311-9321 (2014-08-26)
Current attempts at tissue regeneration utilizing synthetic and decellularized biologic-based materials have typically been met in part by innate immune responses in the form of a robust inflammatory reaction at the site of implantation or grafting. This can ultimately lead
Shawn P Carey et al.
American journal of physiology. Cell physiology, 308(6), C436-C447 (2014-12-17)
Tumor cell invasion through the stromal extracellular matrix (ECM) is a key feature of cancer metastasis, and understanding the cellular mechanisms of invasive migration is critical to the development of effective diagnostic and therapeutic strategies. Since cancer cell migration is
Maria Scaturro et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 123(4), 330-341 (2015-01-06)
Legionella pneumophila is a pathogen widespread in aquatic environment, able to multiply both within amoebae and human macrophages. The aim of this study was to identify genes differently expressed in a spontaneous avirulent Legionella pneumophila serogroup 6 mutant, named Vir-
Michael K L Chu et al.
Diabetes technology & therapeutics, 17(4), 255-267 (2015-02-12)
An implantable, glucose-responsive insulin delivery microdevice was reported previously by our group, providing rapid insulin release in response to hyperglycemic events and efficacy in vivo over a 1-week period when implanted intraperitoneally in rats with diabetes. Herein, we focused on
Charuspong Dissaranan et al.
Cell transplantation, 23(11), 1395-1406 (2013-07-23)
Vaginal delivery is a risk factor for stress urinary incontinence (SUI). Mesenchymal stem cells (MSCs) home to injured organs and can facilitate repair. The goal of this study was to determine if MSCs home to pelvic organs after simulated childbirth
Sadaoki Sakai et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(1), 128-136 (2014-07-22)
Bone fractures markedly reduce quality of life and life expectancy in elderly people. Although osteoporosis increases bone fragility, fractures frequently occur in patients with normal bone mineral density. Because most fractures occur on falling, preventing falls is another focus for
Magdalene Ameka et al.
The Biochemical journal, 464(1), 99-108 (2014-09-06)
The intracellular kinase MEKK2 (mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase kinase 2) is an upstream regulator of JNK (c-Jun N-terminal kinase), but additional functions for MEKK2 have not been well defined. Silencing MEKK2 expression in invasive breast tumour cells markedly inhibits
Yuka Harata-Lee et al.
Immunology and cell biology, 92(10), 815-824 (2014-07-17)
Over the last decade, the significance of the homeostatic CC chemokine receptor-7 and its ligands CC chemokine ligand-19 (CCL19) and CCL21, in various types of cancer, particularly mammary carcinoma, has been highlighted. The chemokine receptor CCX-CKR is a high-affinity receptor
Yanyong Sun et al.
Neuropathology and applied neurobiology, 41(3), 347-370 (2014-03-13)
Insufficient oligodendroglial differentiation of oligodendroglial progenitor cells (OPCs) is suggested to be responsible for remyelination failure and astroglial scar formation in Theiler's murine encephalomyelitis (TME). The aim of the present study is to identify molecular key regulators of OPC differentiation
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页码 1 来自 52