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Hasmik Grigoryan et al.
Analytical chemistry, 88(21), 10504-10512 (2016-11-02)
An important but understudied class of human exposures is comprised of reactive electrophiles that cannot be measured in vivo because they are short-lived. An avenue for assessing these meaningful exposures focuses on adducts from reactions with nucleophilic loci of blood
Simon M Collin
Advances in clinical chemistry, 60, 1-63 (2013-06-04)
Mechanisms postulated to link folate and B12 metabolism with cancer, including genome-wide hypomethylation, gene-specific promoter hypermethylation, and DNA uracil misincorporation, have been observed in prostate tumor cells. However, epidemiological studies of prostate cancer risk, based on dietary intakes and blood
Katherine F Wallis et al.
Environmental and molecular mutagenesis, 62(3), 216-226 (2021-02-23)
Restriction of the sulfur amino acids methionine and cysteine has recently been proposed as potential adjuvant therapy in cancer. While cysteine depletion has been associated with ferroptotic cell death, methionine depletion has not. We hypothesized that comparing the response of
Yan Ji et al.
Neurology, 81(15), 1298-1307 (2013-09-21)
To perform a meta-analysis on the effect of lowering homocysteine levels via B vitamin supplementation on cerebrovascular disease risk. Using clinical trials published before August 2012 to assess stroke events, we used relative risks (RRs) with 95% confidence intervals (95%
Caitlin G Howe et al.
The Journal of nutrition, 144(5), 690-697 (2014-03-07)
Chronic exposure to inorganic arsenic (InAs) through drinking water is a major problem worldwide. InAs undergoes hepatic methylation to form mono- and dimethyl arsenical species (MMA and DMA, respectively), facilitating arsenic elimination. Both reactions are catalyzed by arsenic (+3 oxidation
Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells.
Ying-Sheng Tang et al.
The Journal of nutrition, 147(4), 482-498 (2017-03-03)
Alla V Glushchenko et al.
Antioxidants & redox signaling, 9(11), 1883-1898 (2007-09-01)
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease, complications of pregnancy, cognitive impairment, and osteoporosis. That elevated homocysteine leads to vascular dysfunction may be the linking factor between these apparently unrelated pathologies. Although a growing body of evidence suggests
Irena Selicharová et al.
Biochimica et biophysica acta, 1834(8), 1596-1606 (2013-05-22)
Both cardiovascular disease and liver injury are major public health issues. Hyperhomocysteinemia has been linked to cardiovascular diseases, and defects in methyl group metabolism, often resulting in hyperhomocysteinemia, are among the key molecular events postulated to play a role in
Vipen Batra et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 69, 46-54 (2014-04-12)
The objective of this study was to examine the effect of (60)Co-gamma (γ) radiation on modulation of genomic DNA methylation, if any, of mice maintained (6 weeks) on normal control diet (NCD) and L-methionine supplemented diet (MSD). To elucidate the
Xiao Wei Ji et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 81, 153410-153410 (2020-12-08)
Homocysteine (Hcy) induced vascular endothelial dysfunction is known to be closely associated with oxidative stress and impaired NO system. 1,8-Dihydroxy-3-methoxy-6-methylanthracene-9,10-dione (physcion) has been known to has antioxidative and anti-inflammatory properties. The purpose of the present study was to define the
Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.
Jadavji NM, Bahous RH, Deng L, et al.
The Biochemical Journal, 461(2), 205-212 (2014)
Clare Abbenhardt et al.
The Journal of nutrition, 144(5), 714-721 (2014-03-22)
Folate-mediated one-carbon metabolism is essential for DNA synthesis, repair, and methylation. Perturbations in one-carbon metabolism have been implicated in increased risk of some cancers and may also affect inflammatory processes. We investigated these interrelated pathways to understand their relation. The
Joseph J Ferry et al.
Assay and drug development technologies, 13(4), 221-234 (2015-06-13)
Methylation of histone H3 lysine-4 (H3K4) is an important, regulatory, epigenetic post-translational modification associated with actively transcribed genes. In humans, the principal mediators of this modification are part of the MLL/SET1 family of methyltransferases, which comprises six members, MLLs1-4 and
Maresa E Duffy et al.
The American journal of clinical nutrition, 99(1), 96-106 (2013-11-15)
The task of revising dietary folate recommendations for optimal health is complicated by a lack of data quantifying the biomarker response that reliably reflects a given folate intake. We conducted a dose-response meta-analysis in healthy adults to quantify the typical
Rajendra P Shukla et al.
Talanta, 209, 120560-120560 (2020-01-02)
Antipsychotic clozapine is the most effective medication currently available for schizophrenia. However, clozapine is dramatically underutilized due to its harsh side effects that are not effectively monitored. By continuously monitoring clozapine blood levels, such as use of an implantable glucometer
Beata Olas
Chemico-biological interactions, 217, 49-56 (2014-04-22)
Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST). Hydrogen sulfide, like carbon monoxide (CO) or nitric
Yinyang Hu et al.
Materials science & engineering. C, Materials for biological applications, 72, 77-85 (2016-12-28)
The clinical applications of tradition prodrug are restricted to a certain extent due to its some defects such as side effects, low selectivity and single function. Herein, we designed a theranostic strategy based on the fluorescence resonance energy transfer (FRET)
Ying Wang et al.
The Journal of nutrition, 144(7), 1067-1074 (2014-04-20)
Hyperlipidemia and elevated circulating C-reactive protein (CRP) and total homocysteine (tHcy) concentrations are cardiovascular disease (CVD) risk factors. Previous studies indicated that higher serum carotenoid concentrations were inversely associated with some of these biomarkers. However, whether dietary carotenoid intake is
Biljana A Vuckovic et al.
Croatian medical journal, 54(5), 480-488 (2013-10-31)
To determine the differences in plasma homocysteine levels between three MTHFR 677 genotype subgroups in patients with thrombosis and in controls, as well as between patients with thrombosis and controls with the same MTHFR 677 genotype. This case-control study was
Breige McNulty et al.
The American journal of clinical nutrition, 98(1), 92-98 (2013-05-31)
Supplementation with folic acid (FA) is recommended worldwide before and during early pregnancy because of its proven effect in preventing neural tube defects, but the role of FA after the 12th gestational week (GW) is much less clear. We investigated
M Murad Basar et al.
Indian journal of biochemistry & biophysics, 50(3), 215-220 (2013-08-01)
The aim of the present study was to investigate serum homocysteine levels in patients with erectile dysfunction and to evaluate the relationship between serum homocysteine levels and response to the standard 50 mg phosphodiesterase 5 inhibitor treatment. Twenty-eight erectile dysfunction
Katarína Šebeková et al.
International journal of environmental research and public health, 17(10) (2020-05-28)
Males present higher blood pressure (BP) values, higher prevalence of elevated BP, and a different prevalence of cardiometabolic risk factors when compared with females. We assumed that the trends of risk markers across BP categories (normotension, high normal BP, and
Pratiksha S Sable et al.
Metabolism: clinical and experimental, 62(11), 1607-1622 (2013-07-13)
Our earlier studies show that maternal diets imbalanced in micronutrients like folic acid and vitamin B12 reduced brain docosahexaenoic acid (DHA) and brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the offspring at birth and postnatal d21.
M Flisinski et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(4), 567-576 (2014-09-03)
Muscle weakness and progressive loss of skeletal muscle mass are serious complications of chronic kidney disease (CKD). The pathogenesis of this condition is still poorly understood. The study investigated fibre type distribution and diameter in functionally different skeletal muscles: locomotor
Wanda Velez-Carrasco et al.
The Journal of nutritional biochemistry, 19(6), 362-370 (2007-08-21)
The effects of dietary manipulation of folate and methionine on plasma homocysteine (Hcy) and high-density lipoprotein cholesterol (HDL-C) levels in wild-type and apolipoprotein-E-deficient mice were determined. A low-folate diet with or without folate and/or methionine supplementation in drinking water was
M Messedi et al.
Gene, 527(1), 306-310 (2013-07-06)
Behcet's disease (BD) is a chronic, relapsing, multi-systemic inflammatory disorder of unknown causes. This disease is mainly characterized by mucocutaneous, ocular, vascular, and central nervous system manifestations. The aim of this study is to investigate the associations between C677T and
Dong Wook Kim et al.
Epilepsia, 54(10), e146-e149 (2013-08-29)
Although it is well documented that long-term therapy with older antiepileptic drugs (AEDs) leads to an increase in risk for atherosclerosis, there has been only limited information regarding the vascular risk in patients who are treated with new AEDs. We
Cornelie Nienaber-Rousseau et al.
Gene, 530(1), 113-118 (2013-08-21)
The methylenetetrahydrofolate reductase (MTHFR), cystathione-β-synthase (CBS) and methionine synthase (MTR) genes interact with each other and the environment. These interactions could influence homocysteine (Hcy) and diseases contingent thereon. We determined single nucleotide polymorphisms (SNPs) within these genes, their relationships and
S F Wnuk
Mini reviews in medicinal chemistry, 1(3), 307-316 (2002-10-09)
Substrates that are specific for the "hydrolytic" activities of AdoHcy hydrolase have been recently identified. Upon interaction with the AdoHcy hydrolase such substrates generate the "active" electrophiles which then react with the enzyme nucleophiles to produce covalent inhibition. Dihalohomovinyl and
Khoosheh Khayati et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(2), 598-609 (2017-02-06)
The molecular mechanisms leading to and responsible for age-related, sporadic Alzheimer's disease (AD) remain largely unknown. It is well documented that aging patients with elevated levels of the amino acid metabolite homocysteine (Hcy) are at high risk of developing AD.
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