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Shih-Chia Tso et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(24), 9728-9733 (2013-05-30)
The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are elevated in maple syrup urine disease, heart failure, obesity, and type 2 diabetes. BCAA homeostasis is controlled by the mitochondrial branched-chain α-ketoacid dehydrogenase complex (BCKDC), which is negatively regulated by...
Tian You et al.
DNA and cell biology, 32(5), 252-259 (2013-04-18)
Serum paraoxonase (PON1) is an esterase that is involved in the detoxification of organophosphate insecticides. Emerging lines of evidence have shown that functional polymorphisms in the PON1 gene might play a critical role in increasing susceptibility to organophosphate toxicity, but...
Qian Wang et al.
Journal of the National Cancer Institute, 105(19), 1463-1473 (2013-09-21)
L-type amino acid transporters (LATs) uptake neutral amino acids including L-leucine into cells, stimulating mammalian target of rapamycin complex 1 signaling and protein synthesis. LAT1 and LAT3 are overexpressed at different stages of prostate cancer, and they are responsible for...
Chunhua Ma et al.
Bioorganic & medicinal chemistry, 21(7), 1621-1627 (2013-03-05)
Aminopeptidase N (APN/CD13) over expressed on tumor cells, plays a critical role in tumor invasion, metastasis, and tumor angiogenesis. Here we described the design, synthesis and preliminary activity studies of novel leucine ureido derivatives as aminopeptidase N (APN/CD13) inhibitors. The...
Gary J Schwartz
Endocrinology and metabolism clinics of North America, 42(1), 81-87 (2013-02-09)
This article reviews recent studies identifying two key brain regions as two critical nodes in the neural network where central leucine sensing contributes to whole body energy homeostasis: the mediobasal hypothalamus and the dorsal vagal complex of the caudal brainstem....
Jian-Xu Li et al.
The Biochemical journal, 451(3), 417-426 (2013-02-27)
Most TPSs (terpene synthases) contain plasticity residues that are responsible for diversified terpene products and functional evolution, which provide a potential for improving catalytic efficiency. Artemisinin, a sesquiterpene lactone from Artemisia annua L., is widely used for malaria treatment and...
H Nørrelund et al.
Journal of internal medicine, 260(1), 11-21 (2006-06-23)
It is well known that chronic heart failure (CHF) is associated with insulin resistance and cachexia, but little is known about the underlying substrate metabolism. The present study was undertaken to identify disturbances of basal glucose, lipid and protein metabolism....
Jaleh Varshosaz et al.
Pharmaceutical development and technology, 20(2), 183-196 (2013-11-14)
Haloperidol (Hal) is a ligand that can target sigma 2 receptors over-expressed in non-small cell lung cancer. Hal targeted nanoparticles of bovine serum albumin (BSA) were prepared for pulmonary delivery of doxorubicin (DOX). The conjugation was confirmed by Fourier transform...
Nico P M Smit et al.
Journal of proteomics, 109, 143-161 (2014-06-28)
In this study, we have followed up on previous liquid chromatography (LC) multiple reaction monitoring (MRM) mass spectrometry (MS) approaches for measurement of apolipoprotein (apo) A-I and apo B100 in serum aiming for implementation of a multiplexed assay in a...
Mohammed Nadeem Ahmed Bijle et al.
The journal of contemporary dental practice, 14(1), 96-99 (2013-04-13)
To evaluate awareness of dental surgeons in Pune and Mumbai, India regarding chemomechanical caries removal system (CMCR). Sixty practicing dental surgeons from Mumbai (30) and Pune (30) were surveyed using questionnaire. Qualitative data was collected on the basis of structured...
Sie Huey Lee et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 70, 37-44 (2015-01-24)
Airway mucus hypersecretion is a common clinical feature of many severe respiratory diseases, and when complicated by a recalcitrant bacterial infection, the whole treatment regimen thereby becomes more challenging and protracted. The accumulation of thickened mucus secretions in the lower...
J D Shoemaker et al.
Journal of chromatography, 562(1-2), 125-138 (1991-01-02)
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio...
Xuejing Yu et al.
The FEBS journal, 281(1), 391-400 (2013-11-12)
Branched-chain amino acid aminotransferase (BCAT) plays a key role in the biosynthesis of hydrophobic amino acids (such as leucine, isoleucine and valine), and its substrate spectrum has not been fully explored or exploited owing to the inescapable restrictions of previous...
Cydne A Perry et al.
The Journal of nutrition, 144(12), 1977-1984 (2014-08-15)
Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequate Intakes (AIs). The biotin AI for adults and pregnant women...
Magda S Santos et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(26), 10634-10646 (2013-06-28)
Increasing evidence indicates that individual synaptic vesicle proteins may use different signals, endocytic adaptors, and trafficking pathways for sorting to distinct pools of synaptic vesicles. Here, we report the identification of a unique amino acid motif in the vesicular GABA...
Florian Veillard et al.
Biological chemistry, 393(12), 1471-1476 (2013-05-15)
Bestatin, a specific inhibitor of metalloaminopeptidases,inhibits the growth of Porphyromonas gingivalis. To identify its target enzyme, a library of fluorescent substrates was used but no metalloaminopeptidase activity was found. The aminopeptidase activity of P. gingivalis was bestatin-insensitive and directed exclusively...
Yumi Hayashi et al.
The Journal of biological chemistry, 289(15), 10530-10539 (2014-02-27)
The Lol system comprising five Lol proteins, LolA through LolE, sorts Escherichia coli lipoproteins to outer membranes. The LolCDE complex, an ATP binding cassette transporter in inner membranes, releases outer membrane-specific lipoproteins in an ATP-dependent manner, causing formation of the...
Marika Leenders et al.
Nutrition reviews, 69(11), 675-689 (2011-10-28)
Amino acids function as precursors for de novo protein synthesis. In addition, however, they play a key role as nutritional signals that regulate multiple cellular processes. There is ample in vitro and in vivo evidence showing that muscle tissue responds...
Luc J C van Loon
Current opinion in clinical nutrition and metabolic care, 15(1), 71-77 (2011-11-01)
Amino acids do not merely represent precursors for de-novo protein synthesis, but also function as nutritional signals regulating various metabolic processes. In fact, ample evidence has been generated to show that various tissues respond to changes in amino acid availability...
P Iannoli et al.
Metabolism: clinical and experimental, 48(11), 1432-1436 (1999-12-03)
The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are beneficial to catabolic patients by improving hepatic protein synthesis and nitrogen economy, yet their transport from the intestinal lumen is not well-defined. The leucine transport system in human and rabbit...
Kevin Guo et al.
Analytical chemistry, 81(10), 3919-3932 (2009-03-25)
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be...
Elin Hadler-Olsen et al.
Journal of cellular physiology, 230(1), 160-169 (2014-06-07)
Matrix metalloproteinase 2 (MMP-2) is a proteolytic enzyme implicated in motility, differentiation, and regeneration of skeletal muscle fibers through processing of extracellular substrates. Although MMP-2 has been found to be localized intracellularly in cardiomyocytes where the enzyme is thought to...
E Yildiz et al.
European journal of paediatric dentistry : official journal of European Academy of Paediatric Dentistry, 14(3), 209-214 (2013-12-04)
The aim of this in vitro study is to evaluate the effects of three different caries removal techniques on the microtensile bond strength of adhesive materials to caries-affected dentin. Thirty primary molar teeth were used. The teeth were randomly divided...
Jean Jitomir et al.
Journal of medicinal food, 11(4), 606-609 (2008-12-05)
As obesity rates continue to climb, there is a pressing need for novel weight loss techniques. However, the energy-restricted diets recommended for weight loss typically result in significant amounts of lean tissue loss, in addition to the desired body fat...
Ming-Li Tsai et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(36), 14658-14663 (2013-08-22)
Within Cu-containing electron transfer active sites, the role of the axial ligand in type 1 sites is well defined, yet its role in the binuclear mixed-valent CuA sites is less clear. Recently, the mutation of the axial Met to Leu...
Yazmin Macotela et al.
PloS one, 6(6), e21187-e21187 (2011-07-07)
Environmental factors, such as the macronutrient composition of the diet, can have a profound impact on risk of diabetes and metabolic syndrome. In the present study we demonstrate how a single, simple dietary factor--leucine--can modify insulin resistance by acting on...
Seok-Min Kang et al.
Clinical biochemistry, 44(4), 293-299 (2010-12-21)
We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics. Patients with systolic HF of ischemic origin (n=15) and healthy controls (n=20) participated in this study. Patients with...
Patrícia M Jorge et al.
Basic & clinical pharmacology & toxicology, 116(3), 273-280 (2014-08-30)
The diphenyl ditelluride (DPDT) is a prototype for the development of new biologically active molecules. In previous studies, DPDT showed an elevated cytotoxicity in Chinese hamster fibroblast (V79) cells but the mechanisms for reduction of cell viability still remain unknown....
Beatrice Bocca et al.
Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <...
Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma.
Philippe Bahadoran et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e324-e326 (2013-05-30)
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