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Baruch I Kanner
Nature structural & molecular biology, 20(10), 1142-1144 (2013-10-08)
Sodium-coupled glutamate transporters regulate excitatory signaling in the brain. A new crystal structure shows how the substrate induces changes in the binding pocket of an archaeal transporter homolog, providing new insights into the mechanism of transport.
Amy B Banta et al.
Current protocols in microbiology, 59(1), e130-e130 (2020-12-18)
Facile bacterial genome sequencing has unlocked a veritable treasure trove of novel genes awaiting functional exploration. To make the most of this opportunity requires powerful genetic tools that can target all genes in diverse bacteria. CRISPR interference (CRISPRi) is a
Antonio C Ruzzini et al.
Biochemistry, 52(42), 7428-7438 (2013-09-27)
The meta-cleavage product (MCP) hydrolases utilize a Ser-His-Asp triad to hydrolyze a carbon-carbon bond. Hydrolysis of the MCP substrate has been proposed to proceed via an enol-to-keto tautomerization followed by a nucleophilic mechanism of catalysis. Ketonization involves an intermediate, ES(red)
F Granata et al.
The neuroradiology journal, 26(3), 277-283 (2013-07-19)
The cognitive dysmetria theory suggests a disconnectivity between the dorsolateral prefrontal cortex, thalami and vermis to explain the pathophysiology of schizophrenia. This study investigated the metabolic integrity of this neurologic circuit in patients with schizophrenia using proton magnetic resonance spectroscopy
Jenna Friedt et al.
Nucleic acids research, 42(6), 3857-3870 (2013-12-29)
Pseudouridine synthases introduce the most common RNA modification and likely use the same catalytic mechanism. Besides a catalytic aspartate residue, the contributions of other residues for catalysis of pseudouridine formation are poorly understood. Here, we have tested the role of
Marco Flores-Méndez et al.
Toxicology letters, 229(1), 126-133 (2014-06-24)
Fluoride is an environmental pollutant present in dental products, food, pesticides and water. The latter, is the greatest source of exposure to this contaminant. Structural and functional damages to the central nervous system are present in exposed population. An established
Hee Chan Yoo et al.
Cell metabolism, 31(2), 267-283 (2019-12-24)
Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism, the mitochondrial glutamine transporter has long been unknown. Here, we show that the SLC1A5 variant plays
Jing-Li Gan et al.
Psychiatry research, 223(1), 23-27 (2014-05-17)
Early onset schizophrenia (EOS) is often associated with poorer outcomes, including lack of school education, higher risk of mental disability and resistance to treatment. But the knowledge of the neurobiological mechanism of EOS is limited. Here, using proton magnetic resonance
Wilson I Gonsalves et al.
Journal of the National Cancer Institute, 106(7), doi:10-doi:10 (2014-06-14)
KRAS and BRAF (V600E) mutations are important predictive and prognostic markers, respectively, in colon cancer, but little is known about patient and clinical factors associated with them. Two thousand three hundred twenty-six of 3397 patients in the N0147 phase III
Przemyslaw Swiatkowski et al.
Biochemical and biophysical research communications, 433(3), 354-357 (2013-03-21)
In the pharynx of Caenorhabditis elegans, the accessory subunit MPS-4, homolog to human KCNE1, forms a complex with K(+) channel EXP-2 that terminates the action potential. An aspartate residue critical for KCNE1 function, asp76, is conserved in MPS-4 (asp74). Here
Sara Llufriu et al.
JAMA neurology, 71(7), 840-847 (2014-05-21)
Predicting disease evolution is becoming essential for optimizing treatment decision making in multiple sclerosis (MS). Multiple sclerosis pathologic damage typically includes demyelination, neuro-axonal loss, and astrogliosis. To evaluate the potential of magnetic resonance markers of central nervous system injury to
S K Goergen et al.
Clinical radiology, 69(1), 72-81 (2013-11-12)
To compare diffusion-weighted imaging (DWI) and non-DWI magnetic resonance imaging (MRI), proton MR spectroscopy (1H-MRS), and clinical biomarkers for prediction of 2 year developmental outcome in term infants with perinatal hypoxic-ischaemic encephalopathy (HIE). Nineteen infants ≥36 weeks gestation with HIE
Edi Erwan et al.
Life sciences, 109(1), 65-71 (2014-06-03)
L-Aspartate (L-Asp) and D-aspartate (D-Asp) are physiologically important amino acids in mammals and birds. However, the functions of these amino acids have not yet been fully understood. In this study, we therefore examined the effects of L-Asp and D-Asp in
Xin Yang et al.
Annals of neurology, 75(4), 492-507 (2013-11-19)
Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM). We determined whether glutamate receptors were involved in hypoglycemic WM injury. Mouse optic nerves (MON), CNS WM tracts, were maintained at 37°C with oxygenated
Chih-Ping Yang et al.
Anesthesia and analgesia, 117(6), 1493-1502 (2013-11-22)
Glutamate homeostasis and microglia activation play an important role in the development and maintenance of neuropathic pain. We designed this investigation to examine whether ultra-low dose naloxone administered alone or in combination with morphine could alter the concentration of the
Zhongli Yang et al.
Neuroscience letters, 555, 215-219 (2013-10-01)
Recently, we reported that several polymorphisms and haplotypes in the choline acetyltransferase gene (ChAT) are associated with nicotine dependence (ND). Of them, SNP rs1880676 is of particular interest because: (1) it is a non-synonymous variant located in the coding region
Giles S Kendall et al.
Radiology, 271(1), 230-238 (2014-01-31)
To determine (a) whether diffuse white matter injury of prematurity is associated with an increased choline (Cho)-to-creatine (Cr) ratio and a reduced N-acetylaspartate (NAA)-to-Cho ratio and whether these measures can be used as biomarkers of outcome and (b) if changes
Jennifer L Kellie et al.
Biochemistry, 52(48), 8753-8765 (2013-10-31)
8-Oxoguanine (OG) is one of the most frequently occurring forms of DNA damage and is particularly deleterious since it forms a stable Hoogsteen base pair with adenine (A). The repair of an OG:A mispair is initiated by adenine-DNA glycosylase (MutY)
Velia Minicozzi et al.
The Journal of biological chemistry, 289(16), 11242-11252 (2014-03-04)
In this work we present and compare the results of extensive molecular dynamics simulations of model systems comprising an Aβ1-40 peptide in water in interaction with short peptides (β-sheet breakers) mimicking the 17-21 region of the Aβ1-40 sequence. Various systems
Thanate Juntadech et al.
Biochimica et biophysica acta, 1838(1 Pt B), 319-327 (2013-10-15)
Bacillus thuringiensis Cry4Ba toxin is lethal to mosquito-larvae by forming ion-permeable pores in the target midgut cell membrane. Previously, the polarity of Asn(166) located within the α4-α5 loop composing the Cry4Ba pore-forming domain was shown to be crucial for larvicidal
Michaela M Kraus et al.
Life sciences, 102(1), 49-54 (2014-03-13)
Thalamostriatal fibers are involved in cognitive tasks such as acquisition, learning, processing of sensory events, and behavioral flexibility and might play a role in Parkinson's disease. The aim of the present study was the in vivo electrochemical characterization of the
Tamami Uejima et al.
Acta crystallographica. Section D, Biological crystallography, 69(Pt 3), 345-351 (2013-03-23)
Rab small GTPases regulate vesicle transport in eukaryotes by interacting with various effectors. Guanine nucleotide-exchange factor (GEF) catalyzes the transition from inactive GDP-bound Rab to active GTP-bound Rab. The existence of several GDP-bound intermediates containing the Arabidopsis thaliana Rab5 homologue
Veronica H Flood et al.
Blood, 121(18), 3742-3744 (2013-03-23)
The diagnosis of von Willebrand disease (VWD) is complicated by issues with current laboratory testing, particularly the ristocetin cofactor activity assay (VWF:RCo). We have recently reported a sequence variation in the von Willebrand factor (VWF) A1 domain, p.D1472H (D1472H), associated
Helen N Saada et al.
International journal of radiation biology, 90(12), 1179-1183 (2014-06-18)
To evaluate the modulator role of fish oil (FO) on some biochemical changes in the brain of gamma-irradiated rats (RAD). Male albino rats Sprague Dawley were divided into four groups (n = 10). (i) received vehicle via gavages during 28
T Kajikawa et al.
Journal of dental research, 93(4), 400-405 (2014-01-24)
PLAP-1/asporin is an extracellular matrix protein that is predominantly expressed in the human periodontal ligament (PDL) and has an aspartic acid (D) repeat polymorphism in its N-terminal region. In this study, we hypothesized that the D repeat polymorphism of PLAP-1/asporin
J Li et al.
Clinical radiology, 70(1), 37-41 (2014-12-03)
To assess the role of proton MR spectroscopy (MRS) in the detection of changes in metabolite levels of the cerebellum after heat stroke (HS). The study group consisted of eight patients after HS, with a Glasgow Coma Scale (GCS) score
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L H Voronkov et al.
Likars'ka sprava, (8)(8), 36-42 (2013-06-22)
The article presents data regarding links of I/D angiotensin-converting enzyme (ACE) gene polymorphism and structural changes in the myocardium and predictive value in chronic heart failure (CHF). We did not find association of I/D ACE gene polymorphism and structural changes
Rim Benali-Cherif et al.
Acta crystallographica. Section C, Structural chemistry, 70(Pt 7), 689-692 (2014-07-06)
Two polymorphs of L-aspartic acid hydrochloride, C4H8NO4(+)·Cl(-), were obtained from the same aqueous solution. Their crystal structures have been determined from single-crystal data collected at 100 K. The crystal structures revealed three- and two-dimensional hydrogen-bonding networks for the triclinic and orthorhombic
T M Kuvaeva et al.
Prikladnaia biokhimiia i mikrobiologiia, 49(2), 155-163 (2013-06-26)
The genes encoding putative L-aspartate dehydrogenases (EC 1.4.1.21, ADH) from the mesophilic nitrogen-fixing bacteria Rhodopseudomonas palustris and Bradyrhizobium japonicum were cloned and expressed in Escherichia coli. The respective enzymes in the form of hybrid proteins with N-terminal hexahistidine tags were
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