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Priscila Raquel Martins et al.
Memorias do Instituto Oswaldo Cruz, 103(3), 244-250 (2008-06-12)
A polysaccharide-rich fraction (ATF) of medicinal mushroom Agaricus brasiliensis was evaluated on the candidacidal activity, H2O2 and nitric oxide (NO) production, and expression of mannose receptors by murine peritoneal macrophages. Mice received three intraperitoneal (i.p.) injections of ATF and after
Priscila Raquel Martins et al.
The journal of venomous animals and toxins including tropical diseases, 23, 17-17 (2017-03-28)
Agaricus brasiliensis is a medicinal mushroom with immunomodulatory and antitumor activities attributed to the β-glucans presented in the polysaccharide fraction of its fruiting body. Since β-glucans enhance cellular immunoresponsiveness, in this study we aimed to evaluate the effect of an
Svenja Sladek et al.
Drug delivery and translational research, 8(5), 1421-1435 (2018-06-28)
Polyelectrolyte nanoparticle constructs (NPs) comprising salmon calcitonin (sCT), chitosan (CS), and hyaluronic acid (HA) were previously established as having anti-inflammatory potential when injected via the intra-articular (i.a.) route to a mouse model. We attempted to translate the formulation to a
Konerirajapuram N Sulochana et al.
The Journal of biological chemistry, 280(30), 27935-27948 (2005-06-01)
Excessive angiogenesis is involved in many human diseases, and inhibiting angiogenesis is an important area of drug development. There have been conflicting reports as to whether decorin could function as an angiogenic inhibitor when used as an extracellular soluble factor.
Anne Kiang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 14(4), 588-598 (2006-05-31)
Excessive complement activation can result in extreme tissue damage and systemic inflammatory responses, similar to innate immune responses rapidly elicited after systemic adenovirus (Ad) injections. To determine if Ad interactions with the complement system impact upon Ad-induced innate immune responses
Xue Q Liu et al.
Immunology, 125(1), 14-20 (2008-09-19)
The development and maintenance of memory B cells (MBC) is dependent on germinal centres (GC) with follicular dendritic cell (FDC) networks. We have previously shown that FDC networks within GC of the spleen express a novel ligand for CD38 and
Atsuko Hayashida et al.
The American journal of pathology, 174(2), 509-518 (2009-01-17)
In pneumonia caused by the bacterium Staphylococcus aureus, the intense inflammatory response that is triggered by this infection can lead to the development of lung injury. Little is known, however, about the impact of specific virulence factors on this inflammatory
Stefano G Daniele et al.
Science signaling, 8(376), ra45-ra45 (2015-05-15)
Synucleinopathies, such as Parkinson's disease and diffuse Lewy body disease, are progressive neurodegenerative disorders characterized by selective neuronal death, abnormal accumulation of misfolded α-synuclein, and sustained microglial activation. In addition to inducing neuronal toxicity, higher-ordered oligomeric α-synuclein causes proinflammatory responses
G Teti et al.
Infection and immunity, 61(1), 227-235 (1993-01-01)
Cytokines are suspected of playing an important role in the pathophysiology of septic shock. This study was undertaken to determine whether tumor necrosis factor alpha (TNF-alpha) induces the production of other cytokines and mediates mortality in a neonatal rat model
Jean-Pierre Louboutin et al.
Antioxidants (Basel, Switzerland), 3(2), 414-438 (2014-01-01)
HIV-1 trans-acting protein Tat, an essential protein for viral replication, is a key mediator of neurotoxicity. If Tat oxidant injury and neurotoxicity have been described, consequent neuroinflammation is less understood. Rat caudate-putamens (CPs) were challenged with Tat, with or without
Jami E Milam et al.
The American journal of pathology, 176(1), 218-226 (2009-12-02)
To investigate the role of CD11c(+) cells in endotoxin-induced acute lung injury, wild-type or CD11c-diphtheria toxin receptor transgenic mice were treated with intraperitoneal diphtheria toxin (5 ng/g b.wt.) in the presence or absence of intratracheal lipopolysaccharide (51 microg). Lipopolysaccharide treatment
Peng-cheng Xu et al.
BMC immunology, 16, 10-10 (2015-04-17)
C-reactive protein (CRP) exerts prothrombotic effects through dissociating from pentameric CRP (pCRP) into modified or monomeric CRP (mCRP). However, although the high prevalence of venous thromboembolism (VTE) in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has been identified, it
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