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Polysaccharide-rich fraction of Agaricus brasiliensis enhances the candidacidal activity of murine macrophages.

Priscila Raquel Martins et al.

Memorias do Instituto Oswaldo Cruz, 103(3), 244-250 (2008-06-12)

A polysaccharide-rich fraction (ATF) of medicinal mushroom Agaricus brasiliensis was evaluated on the candidacidal activity, H2O2 and nitric oxide (NO) production, and expression of mannose receptors by murine peritoneal macrophages. Mice received three intraperitoneal (i.p.) injections of ATF and after

Priscila Raquel Martins et al.

The journal of venomous animals and toxins including tropical diseases, 23, 17-17 (2017-03-28)

Agaricus brasiliensis is a medicinal mushroom with immunomodulatory and antitumor activities attributed to the β-glucans presented in the polysaccharide fraction of its fruiting body. Since β-glucans enhance cellular immunoresponsiveness, in this study we aimed to evaluate the effect of an

Intra-articular delivery of a nanocomplex comprising salmon calcitonin, hyaluronic acid, and chitosan using an equine model of joint inflammation.

Svenja Sladek et al.

Drug delivery and translational research, 8(5), 1421-1435 (2018-06-28)

Polyelectrolyte nanoparticle constructs (NPs) comprising salmon calcitonin (sCT), chitosan (CS), and hyaluronic acid (HA) were previously established as having anti-inflammatory potential when injected via the intra-articular (i.a.) route to a mouse model. We attempted to translate the formulation to a

Peptides derived from human decorin leucine-rich repeat 5 inhibit angiogenesis.

Konerirajapuram N Sulochana et al.

The Journal of biological chemistry, 280(30), 27935-27948 (2005-06-01)

Excessive angiogenesis is involved in many human diseases, and inhibiting angiogenesis is an important area of drug development. There have been conflicting reports as to whether decorin could function as an angiogenic inhibitor when used as an extracellular soluble factor.

Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system.

Anne Kiang et al.

Molecular therapy : the journal of the American Society of Gene Therapy, 14(4), 588-598 (2006-05-31)

Excessive complement activation can result in extreme tissue damage and systemic inflammatory responses, similar to innate immune responses rapidly elicited after systemic adenovirus (Ad) injections. To determine if Ad interactions with the complement system impact upon Ad-induced innate immune responses

Soluble CD38 significantly prolongs the lifespan of memory B-cell responses.

Xue Q Liu et al.

Immunology, 125(1), 14-20 (2008-09-19)

The development and maintenance of memory B cells (MBC) is dependent on germinal centres (GC) with follicular dendritic cell (FDC) networks. We have previously shown that FDC networks within GC of the spleen express a novel ligand for CD38 and

Staphylococcus aureus beta-toxin induces lung injury through syndecan-1.

Atsuko Hayashida et al.

The American journal of pathology, 174(2), 509-518 (2009-01-17)

In pneumonia caused by the bacterium Staphylococcus aureus, the intense inflammatory response that is triggered by this infection can lead to the development of lung injury. Little is known, however, about the impact of specific virulence factors on this inflammatory

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.

Stefano G Daniele et al.

Science signaling, 8(376), ra45-ra45 (2015-05-15)

Synucleinopathies, such as Parkinson's disease and diffuse Lewy body disease, are progressive neurodegenerative disorders characterized by selective neuronal death, abnormal accumulation of misfolded α-synuclein, and sustained microglial activation. In addition to inducing neuronal toxicity, higher-ordered oligomeric α-synuclein causes proinflammatory responses

Cytokine appearance and effects of anti-tumor necrosis factor alpha antibodies in a neonatal rat model of group B streptococcal infection.

G Teti et al.

Infection and immunity, 61(1), 227-235 (1993-01-01)

Cytokines are suspected of playing an important role in the pathophysiology of septic shock. This study was undertaken to determine whether tumor necrosis factor alpha (TNF-alpha) induces the production of other cytokines and mediates mortality in a neonatal rat model

Oxidative Stress Is Associated with Neuroinflammation in Animal Models of HIV-1 Tat Neurotoxicity.

Jean-Pierre Louboutin et al.

Antioxidants (Basel, Switzerland), 3(2), 414-438 (2014-01-01)

HIV-1 trans-acting protein Tat, an essential protein for viral replication, is a key mediator of neurotoxicity. If Tat oxidant injury and neurotoxicity have been described, consequent neuroinflammation is less understood. Rat caudate-putamens (CPs) were challenged with Tat, with or without

CD11c+ cells are required to prevent progression from local acute lung injury to multiple organ failure and death.

Jami E Milam et al.

The American journal of pathology, 176(1), 218-226 (2009-12-02)

To investigate the role of CD11c(+) cells in endotoxin-induced acute lung injury, wild-type or CD11c-diphtheria toxin receptor transgenic mice were treated with intraperitoneal diphtheria toxin (5 ng/g b.wt.) in the presence or absence of intratracheal lipopolysaccharide (51 microg). Lipopolysaccharide treatment

C-reactive protein enhances activation of coagulation system and inflammatory response through dissociating into monomeric form in antineutrophil cytoplasmic antibody-associated vasculitis.

Peng-cheng Xu et al.

BMC immunology, 16, 10-10 (2015-04-17)

C-reactive protein (CRP) exerts prothrombotic effects through dissociating from pentameric CRP (pCRP) into modified or monomeric CRP (mCRP). However, although the high prevalence of venous thromboembolism (VTE) in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has been identified, it

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