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Takahiro Tsuji et al.
Annals of hematology, 93(5), 821-826 (2014-04-08)
Lymphoma-associated hemophagocytic syndrome (LAHS), which is the major subtype of adult-onset secondary hemophagocytic lymphohistiocytosis (HLH), has a poor outcome. Although the early diagnosis and treatment of LAHS contributes to a better outcome, the lack of mass formation and the absence...
[Early replenishment of iron reserves!].
MMW Fortschritte der Medizin, 155(16), 26-26 (2013-11-28)
Samantha Lane et al.
The West Virginia medical journal, 109(6), 22-23 (2014-01-01)
Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome of extreme inflammation caused by pathologic activation of the immune system. Diagnosis of HLH is challenging as the clinical presentation is similar to common medical entities such as sepsis. When a source of...
Victoria Arija et al.
The British journal of nutrition, 112(11), 1896-1904 (2014-10-18)
A prospective nested case-control study within the PREvention with MEDiterranean Diet (PREDIMED) was conducted to evaluate the relationship between excess body Fe (measured as serum ferritin (SF), soluble transferrin receptor (sTfR) and sTfR:ferritin ratio) and the risk of type 2...
N Taheri et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 26(1), 34-38 (2015-01-13)
Hepcidin prevents absorption of iron from the intestine and inhibits release of iron from macrophages and hepatocytes. For this reason, it seems that high levels of hepcidin are a predisposing factor for anemia in chronic inflammatory conditions such as chronic...
Kieuhoa T Vo et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(28), 3169-3176 (2014-08-27)
Neuroblastoma (NB) is a heterogeneous tumor arising from sympathetic tissues. The impact of primary tumor site in influencing the heterogeneity of NB remains unclear. Children younger than age 21 years diagnosed with NB or ganglioneuroblastoma between 1990 and 2002 and...
Inverted cortico-medullary differentiation of renal hemosiderosis.
Ankur Gupta et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 25(1), 170-171 (2014-01-18)
Seth M Armah et al.
The Journal of nutrition, 143(7), 1136-1140 (2013-05-24)
Many algorithms have been developed in the past few decades to estimate nonheme iron absorption from the diet based on single meal absorption studies. Yet single meal studies exaggerate the effect of diet and other factors on absorption. Here, we...
Wen-Rong Feng et al.
Gene, 544(2), 184-190 (2014-04-29)
Marsupenaeus japonicus is a shrimp species of great value in the Chinese aquaculture industry. Given the susceptibility to viral diseases, research efforts have focused on the molecular characteristics of the shrimp's immune mechanisms. Ferritin is well known for its iron...
Plasma hepcidin of Ethiopian highlanders with steady-state hypoxia.
Erika L Lundgrin et al.
Blood, 122(11), 1989-1991 (2013-09-14)
Shoko Shinoda et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(1), G89-G97 (2014-05-17)
Regular "mucosal block" is characterized by decreased uptake of a normal iron load 3-72 h after the administration of excess iron (generally 10 mg) to iron-deficient animals. We found that short-acting mucosal block could be induced by much lower iron...
Caleb Ho et al.
American journal of clinical pathology, 141(1), 62-71 (2013-12-18)
To evaluate the amount of hemophagocytosis in 64 marrow core biopsy specimens and aspirates from 58 patients with clinical suspicion for secondary hemophagocytic lymphohistiocytosis (HLH) or reported findings of hemophagocytosis. A review of medical records assigned patients to a low-risk...
Roman Praschberger et al.
Biochimica et biophysica acta, 1842(9), 1406-1412 (2014-05-27)
Mutations in the only known mammalian iron exporter ferroportin cause a rare iron overload disorder termed ferroportin disease. Two distinct clinical phenotypes are caused by different disease mechanisms: mutations in ferroportin either cause loss of iron export function or gain...
Crystal D Karakochuk et al.
The Journal of nutrition, 145(1), 134-142 (2014-12-21)
Anemia is common in Cambodian women. Potential causes include micronutrient deficiencies, genetic hemoglobin disorders, inflammation, and disease. We aimed to investigate factors associated with anemia (low hemoglobin concentration) in rural Cambodian women (18-45 y) and to investigate the relations between...
Colin I Cercamondi et al.
The Journal of nutrition, 143(8), 1233-1239 (2013-06-14)
Home fortification with lipid-based nutrient supplements (LNSs) is a promising approach to improve bioavailable iron and energy intake of young children in developing countries. To optimize iron bioavailability from an LNS named complementary food fortificant (CFF), 3 stable isotope studies...
M Pasalar et al.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 20(11), 726-731 (2015-01-21)
This study investigated the prevalence of iron-deficiency anaemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency and β-thalassaemia trait among Arab migrating nomad children in southern Islamic Republic of Iran. Blood samples were analysed from 134 schoolchildren aged < 18 years (51 males, 83...
M Piagnerelli et al.
Acta clinica Belgica, 68(1), 22-27 (2013-05-01)
Altered iron metabolism plays a central role in the development of anaemia in critically ill patients but the time course of iron status in septic and non-septic critically ill patients has not been well defined. Prospective study in a 34-bed...
Abhijit V Kshirsagar et al.
The American journal of medicine, 126(6), 541-541 (2013-04-20)
Intravenous iron is used widely in hemodialysis, yet there are limited data on the effectiveness of contemporary dosing strategies or formulation type. We conducted a retrospective cohort study using data from the clinical database of a large dialysis provider (years...
A Tabarroki et al.
Leukemia, 28(7), 1486-1493 (2014-01-11)
Pulmonary hypertension (PH) is a frequently under recognized complication of myelofibrosis (MF). The pathophysiology of PH in MF is unknown and no definitive therapies have been established. We studied 15 patients with MF-associated PH and compared their echocardiographic and PH...
Jianping Wu et al.
Archives of medical research, 45(3), 251-256 (2014-03-25)
This study was designed to investigate the association between serum ferritin concentration (SF) and hepatitis B virus infected patients with acute-on-chronic liver failure (AoCLF). In addition, we analyzed whether SF levels are associated with mortality in AoCLF patients. One hundred...
[Not Available].
Johann Steurer
Praxis, 102(23), 1432-1433 (2013-11-14)
Barindra Sana et al.
The Journal of biological chemistry, 288(45), 32663-32672 (2013-09-14)
Archaeoglobus fulgidus ferritin (AfFtn) is the only tetracosameric ferritin known to form a tetrahedral cage, a structure that remains unique in structural biology. As a result of the tetrahedral (2-3) symmetry, four openings (∼45 Å in diameter) are formed in...
Roberta Misaggi et al.
Gene, 535(2), 327-335 (2013-11-19)
Ferritin is best known as the key molecule in intracellular iron storage, and is involved in several metabolic processes such as cell proliferation, differentiation and neoplastic transformation. We have recently demonstrated that the shRNA silencing of the ferritin heavy subunit...
I G Panagiotopoulou et al.
Annals of the Royal College of Surgeons of England, 96(4), 289-293 (2014-05-02)
We receive fast track referrals on the basis of iron deficiency anaemia (IDA) for patients with normocytic anaemia or for patients with no iron studies. This study examined the yield of colorectal cancer (CRC) among fast track patients to ascertain...
Wei Li et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 29(7), 710-713 (2013-07-11)
To explore the time-dependent changes in the expressions of ferritin (Fn) and ferroportin (FPN) in macrophages infected with Mycobacterium (M.) tuberculosis of highly virulent strain (H37Rv strain) and Bacillus Calmette-Guerin (BCG) strain. RAW264.7 macrophages were respectively infected with M. tuberculosis...
Francesca Vinchi et al.
Gastroenterology, 146(5), 1325-1338 (2014-02-04)
The liver has one of the highest rates of heme synthesis of any organ. More than 50% of the heme synthesized in the liver is used for synthesis of P450 enzymes, which metabolize exogenous and endogenous compounds that include natural...
The effect of iron overload on red blood cell morphology.
Etheresia Pretorius et al.
Lancet (London, England), 383(9918), 722-722 (2014-02-04)
Nicolai Petry et al.
The Journal of nutrition, 143(8), 1219-1224 (2013-06-21)
Iron bioavailability from common beans is negatively influenced by phytic acid (PA) and polyphenols (PPs). Newly developed low-PA (lpa) beans with 90% less PA and variable PPs might improve iron bioavailability. The aim of this study was to evaluate the...
G Waeber et al.
Revue medicale suisse, 9(404), 2002-2002 (2013-12-10)
Dysmetabolic hyperferritinemia is currently the most frequent cause of elevated ferritin levels in the general population. Whether dysmetabolic hyperferritinemia is a cause or an effect of insulin resistance is still a matter of debate. Still, several findings have been well...
Therese von Hanno et al.
Investigative ophthalmology & visual science, 54(10), 7053-7060 (2013-10-10)
To investigate if markers of iron body stores and hemoglobin are associated with retinal vascular caliber. This was a population-based study including 2993 participants of the fifth and sixth surveys of the Tromsø Study in Norway, conducted in 2001-2002 and...
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