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Fluorination

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facet applications:Fluorination
facet content type:Technical Article
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磺酰氯和磺酰胺
磺酰氯通常被选用为药物化学中的结构单元,因为它们能够容易地与杂环胺反应而产生复合磺酰胺。
(-)-反-α,α'-(2,2-二甲基-1,3-二氧戊环-4,5-二基)双(二苯甲醇)
由Seebach小组开发的手性助剂TADDOL(α,α,α,α-四芳基-1,3-二氧戊环-4,5-二甲醇)在不对称合成中具有多种应用,包括从用作化学计量手性试剂或用于路易斯酸介导的反应,到在催化加氢和立体规则复分解聚合中发挥作用。
PhenoFluor™ Solution for Convenient, One-step Deoxyfluorination
The functional-group-tolerant, one-step conversion of phenols to aryl fluorides is a highly desirable process. PhenoFluor™ solution, provides straightforward method to fluorinate alcohol and phenols without preactivation and regioselectively fluorinate highly functionalized late-stage intermediates.
XtalFluor-E® and XtalFluor-M®: Convenient, Crystalline Deoxofluorination Reagents
This is an article regarding XtalFluor-E® and XtalFluor-M®: Convenient, Crystalline Deoxofluorination Reagents.
TADDOL
The chiral auxiliaries TADDOLs (α,α,α,α-tetraaryl-1,3-dioxolane-4,5- dimethanols) developed by Seebach's group have found numerous applications in asymmetric synthesis ranging from utilization as stoichiometric chiral reagents or in Lewis acid mediated reactions, to roles in catalytic hydrogenation and stereoregular metathesis polymerization.
Acid Halogenation Reagents
Fluoroamidinium salts were an advance in acid halogenation. Compared to chlorides, acid fluorides have greater water stability and a lack of conversion to the corresponding oxazolones upon treatment with organic bases.
Fluoroalkylation: Expansion of Togni Reagents
The fluoroalkylation toolbox now includes Togni reagents, hypervalent iodine perfluoroalkylation reagents, fluoroalkyl bromides, silanes, carboxylates, and sulfonyl fluorides for late stage fluoroalkylation.
Fluorinated Azides: Click Chemistry Meets Fluorine
Fluorinated azides are a new tool that can be used to introduce fluorinated groups to molecules. These molecules can utilize click chemistry to easily add fluorinated groups.
Recent Advances in the Catalytic Transformations
This article details the latest progress in synthesizing alkylsulfonyl fluorides through different approaches that utilize photoredox catalysis, electrocatalysis, transition-metal catalysis, and organocatalysis. The alkylsulfonyl fluorides thus prepared could be utilized further in sulfur(VI) fluoride exchange (SuFEx) click reactions.
Diethylaminosulfur Trifluoride (DAST)
Diethylaminosulfur trifluoride (DAST) facilitates nucleophilic fluorination in selective reactions with alcohols, ketones, and other compounds.
Sulfonyl Chlorides and Sulfonamides
Sulfonyl chlorides are often chosen as building blocks in medicinal chemistry for their ability to easily react with heterocyclic amines to create complex sulfonamides.
AISF: A Stable, Solid Alternative to Sulfuryl Fluoride Gas
A solid and bench-stable alternative to sulfuryl fluoride gas has been developed, 4-(Acetylamino)phenyl]imidodisulfuryl difluoride (ASIF). ASIF is a shelf-stable, crystallilne reagent for the installation of the valuable SO2F functional group.
Trimethyl(trifluoromethyl)silane (Ruppert–Prakash Reagent)
Technical article for Trimethyl(trifluoromethyl)silane (Ruppert–Prakash Reagent)
Deoxyfluorination with 2-Pyridinesulfonyl Fluoride (PyFluor)
The prevalence of organofluorine compounds in industry and drug design necessitates the ability to introduce C–F bonds to molecules.
AlPhos and [(AlPhosPd)2•COD] for Pd-Catalyzed Fluorination
Fluorine containing aromatics (ArF) are desirable compounds with applications in medicinal chemistry and the agricultural industry.
Trifluoromethylator™, A Robust Arene Trifluoromethylation Reagent: (Phen)Cu-CF3*
(Phen)Cu-CF3 (cat. #L510009) is an easily handled, thermally stable, single-component reagent for the trifluoromethylation of aryl iodides.
Selectfluor™
Selectfluor™ (F-TEDA) is a mild, stable reagent for electrophilic fluorination, enhancing user-friendly fluorination reactions.