Merck
Search Within
Applications
Content Type
Applied Filters:
Applications:Protein labeling and modification
Content Type:Technical Article
Showing 1-30 of 63 results
Sort by Relevance
用于抗体表征的酶
抗体现今是治疗药物中成长最快的类别
NIR荧光染料
NIR荧光染料
肽偶联剂选择指南
Novabiochem®可提供大量的偶联剂用于原位活化。原位活化试剂易于使用 - 即使是利用空间位阻氨基酸,并且它们的使用通常没有副反应。
聚糖标记
蛋白质的结构修饰对于活细胞是必不可少的。发生调节异常时,它们往往是会引发疾病。聚糖是生物系统中许多结构变异的原因,它们在细胞表面的表现通常被称为“糖”。
肽聚糖
肽聚糖(PGN)的基本结构含有N-乙酰葡糖胺(GlcNAc)与N-乙酰胞壁酸交替单元的碳水化合物主链,其中N-乙酰胞壁酸残基与肽交联。
自组装单层:烷硫醇的优点
我们提供了一篇关于自组装单层的文章:烷硫醇的优点。
Rink酰胺(RAM)树脂
目前已经开发了多种4-((2,4-二甲氧基苯基)(芴甲氧羰基-氨基)甲基)苯氧基烷基官能化载体用于肽羧酰胺的合成。
手性胺
手性胺已被广泛用于不对称合成中,例如用作对映选择性去质子化反应中的手性碱,或用于拆分消旋的酸。
固相合成
多肽是采用固相FMOC或BOC化学法在PEG-聚苯乙烯载体树脂上合成的。合成完成后,先去除侧链保护基团,同时从树脂上切割多肽。随后,将经切割和去保护的多肽材料沉淀、清洗并溶解在含H2O/ACN/HOAC的缓冲液中,然后进行冻干处理。
O-聚糖
O-连接糖蛋白通常是分子量>200kDa的大蛋白。糖基化通常发生在高密度簇上,并可占总量的50-80%。
Ni-NTA-Atto共轭物
Ni-NTA-Atto共轭物为 His 标记的融合蛋白提供特异性和高灵敏度的检测。
DMABA Derivatization: Aminophospholipid Detection Multiplexing
In this video Dr. Robert Murphy, professor at University of Colorado - Denver, discusses DMABA Derivatization: Aminophospholipid Detection Multiplexing.
Proline Derivatives and Analogs
Proline analogues are promising candidates for tuning the biological, pharmaceutical, or physicochemical properties of naturally occuring, as well as de novo designed, linear, and, cyclic peptides.
EX-CELL® Glycosylation Adjust (GAL+)
Our protein quality supplement, EX-CELL® Glycosylation Adjust (Gal+), provides customers with a novel chemically defined product which targets glycosylation attributes.
N-Linked Glycans Overview
N-linked glycosylation, modification, and degradation
Methods and Matrices for Mass Spectrometry of Glycans
Glycosylation is known to have profound influence on various physiochemical, cellular and biological functions of proteins. Alterations in this modification are known to affect the immune system and have been associated with various pathological states such as cancer, rheumatoid arthritis
O Linked Glycans
O-Linked glycans are usually attached to the peptide chain through serine or threonine residues. O-Linked glycosylation is a true post-translational event and does not require a consensus sequence. The most common type of O-linked glycans contain an initial GalNAc residue
Peptide Stability
When selecting peptides for custom synthesis, several important factors should be considered during the design process. These considerations include sequence length, solubility and sequence stability.
Glycoprotein Deglycosylation
Information about Glycoprotein deglycosylation. The diversity of oligosaccharide structures, both O-linked and N-linked, often results in heterogeneity in the mass and charge of glycoproteins.
Chiral Amines in Asymmetric Synthesis
Chiral amines have found widespread application in asymmetric synthesis serving, for instance, as chiral bases in enantioselective deprotonation reactions or being valuable substances for resolving racemic mixtures of acids.
Post Translational Modification
Post-translational modifications such as glycosylation, phosphorylation, and sulfation, to name a few, serve many functions. As a result, the analysis of proteins and their post-translational modifications is particularly important for the study of diseases where multiple genes are known to
Peptidoglycan Structure, Biosynthesis and Function
The basic structure of peptidoglycan (PGN) contains a carbohydrate backbone of alternating units of N-acetylglucosamine (GlcNAc) and Nacetylmuramic acid, with the N-acetylmuramic acid residues cross-linked to peptides.
Glycosyltransferases
Glycosyltransferases were initially considered to be specific for a single glycosyl donor and acceptor, which led to the one enzyme-one linkage concept. Subsequent observations have refuted the theory of absolute enzymatic specificity by describing the transfer of analogs of some
Introduction to Proximity Labeling
A novel method has been developed to tag antibodies with a photoreactive iridium catalyst. Light activates the catalyst to convert a diazirine compound into a reactive carbene intermediate that can label membrane proteins in close proximity. The diazirine adds a
ChiPros Chiral Amines
Chiral amines play an important role in stereoselective organic synthesis. They are used directly as resolving agents, building blocks, or chiral auxiliaries.
Page 1 of 3
Page 1 of 3