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Jason M Sobota et al.
Journal of bacteriology, 196(11), 1980-1991 (2014-03-25)
In Escherichia coli, aromatic compound biosynthesis is the process that has shown the greatest sensitivity to hydrogen peroxide stress. This pathway has long been recognized to be sensitive to superoxide as well, but the molecular target was unknown. Feeding experiments
Robert E Brennan et al.
BMC microbiology, 15, 99-99 (2015-05-13)
Periplasmically localized copper-zinc co-factored superoxide dismutase (SodC) enzymes have been identified in a wide range of Gram-negative bacteria and are proposed to protect bacteria from exogenously produced toxic oxygen radicals, which indicates the potential significance of a Coxiella burnetii SodC.
Julia E Martin et al.
PLoS genetics, 11(3), e1004977-e1004977 (2015-03-17)
Escherichia coli does not routinely import manganese, but it will do so when iron is unavailable, so that manganese can substitute for iron as an enzyme cofactor. When intracellular manganese levels are low, the cell induces the MntH manganese importer
Priyanka Singh et al.
Antonie van Leeuwenhoek, 108(3), 711-720 (2015-07-15)
The type strain DCY99(T) was isolated from soil collected from a ginseng field in Hwacheon, Republic of Korea. Strain DCY99(T) is Gram-negative, non-spore forming, motile, rod-shaped, and strictly aerobic. The bacteria grow optimally at 25-30 °C and pH 6.0-6.5. Phylogenetically
Syed Moshfiqur Rahman et al.
Reproductive toxicology (Elmsford, N.Y.), 53, 68-74 (2015-04-02)
The essential element manganese (Mn) might be toxic at excess exposure. We assessed the impact of elevated Mn exposure through drinking water during pregnancy on birth size in a population-based cohort(n = 1695) in rural Bangladesh. Concentrations of water Mn
J F Zhang et al.
Journal of animal science, 93(4), 1656-1665 (2015-05-29)
A total of 400 1-d-old Arbor Acres broiler chicks were raised at a recommended environmental temperature from d 1 to 20 (experimental day [ED] = ED1 to ED20). On ED21, the chicks were weighed and reallocated into 5 treatment groups
Snežana Tepavčević et al.
Endocrine, 50(1), 193-201 (2015-02-24)
Polycystic ovary syndrome (PCOS) is associated with an altered plasma lipid profile and increased risk for cardiovascular diseases. We hypothesized that molecular mechanisms underlying cardiac pathology in PCOS involve changes in expression and subcellular localization of several key proteins involved
Nicholas Cox et al.
Science (New York, N.Y.), 345(6198), 804-808 (2014-08-16)
The photosynthetic protein complex photosystem II oxidizes water to molecular oxygen at an embedded tetramanganese-calcium cluster. Resolving the geometric and electronic structure of this cluster in its highest metastable catalytic state (designated S3) is a prerequisite for understanding the mechanism
Shu-Hui Dai et al.
International journal of molecular sciences, 15(8), 14591-14609 (2014-09-10)
Oxidative stress is a well-established event in the pathology of several neurobiological diseases. Sirt3 is a nicotinamide adenine nucleotide (NAD+)-dependent protein deacetylase that regulates mitochondrial function and metabolism in response to caloric restriction and stress. This study aims to investigate
Johny Nicolas et al.
Environmental science. Processes & impacts, 17(11), 1952-1958 (2015-09-26)
The wide application and production of nanotechnology have increased the interest in studying the toxicity of nano- and micro-sized particles escaping into air from various aspects of the production process. Metal oxides (MOs) are one particular class of particles that
M W Roomi et al.
International journal of oncology, 44(3), 986-992 (2014-01-01)
Strong clinical and experimental evidence demonstrates association of elevated levels of matrix metalloproteinase MMP-9 with cancer progression, metastasis and shortened patient survival, as it plays a key role in tumor cell invasion and metastasis by digesting the basement membrane and
Xiang Sheng et al.
Biochemistry, 53(27), 4455-4466 (2014-06-26)
Pyruvate carboxylase (PC) catalyzes the carboxylation of pyruvate to produce oxaloacetate. Its activity is directly related to insulin release and thus PC has recently attracted great interest as a potential target for diabetes treatment. In this article, the catalytic mechanism
Qi Ye et al.
Environmental toxicology and pharmacology, 40(1), 333-341 (2015-07-21)
Manganese in excess promotes unstable emotional behavior. Our previous study showed that olfactory manganese uptake into the brain is altered in Hfe(-/-) mice, a model of iron overload hemochromatosis, suggesting that Hfe deficiency could modify the neurotoxicity of airborne manganese.
Wangning Yu et al.
PloS one, 9(10), e110319-e110319 (2014-10-22)
Saccharomonospora viridis is a thermophilic actinomycete that may have biotechnological applications because of its dye decolorizing activity, though the enzymatic oxidative system responsible for this activity remains elusive. Bioinformatic analysis revealed a DyP-type peroxidase gene in the genome of S.
Jingjing Xie et al.
Poultry science, 93(4), 959-969 (2014-04-08)
Manganese is an essential microelement. Manganese deficiency affects reproduction performance and reproductive hormones in layers. However, little is known about its effects and the possible mechanism in regulating reproduction in broiler breeder hens. In the current study, broiler breeder hens
M Sidoryk-Wegrzynowicz et al.
Journal of internal medicine, 273(5), 466-477 (2013-01-31)
Manganese (Mn) is an essential trace element that is required for maintaining proper function and regulation of numerous biochemical and cellular reactions. Despite its essentiality, at excessive levels Mn is toxic to the central nervous system (CNS). Increased accumulation of
Aldo Nicosia et al.
BioMed research international, 2015, 437328-437328 (2015-02-24)
Due to anthropogenic activities the relative concentrations of cadmium and manganese have increased in the marine environment. Cephalopods are able to accumulate such metals and, as inhabitant of coastal waters, Octopus vulgaris is continuously exposed to anthropogenic activities. Since no
Sang Jun Han et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(9), 1497-1506 (2015-07-05)
Progression of acute kidney injury to chronic kidney disease (CKD) is associated with inadequate recovery of damaged kidney. Hydrogen sulfide (H2S) regulates a variety of cellular signals involved in cell death, differentiation and proliferation. This study aimed to identify the
M Waheed Roomi et al.
International journal of oncology, 45(2), 887-894 (2014-05-29)
Brain tumors are highly aggressive tumors that are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions that degrade the extracellular matrix (ECM) and basement membrane, allowing cancer cells to spread to distal organs. Proteases play a key
Marin Tota et al.
Archives of environmental & occupational health, 70(3), 126-132 (2014-06-27)
Environmental impact of natural gas facility near Molve (Podravina, Croatia) was assessed using hares (Lepus europaeus Pallas) as biomonitors. Elevated levels of heavy metals in the environment lead to their accumulation in different tissues of hares. The authors have tested
Michael Challenor et al.
Biochimie, 112, 160-171 (2015-03-21)
Glutamate excitotoxicity contributes to damage following injury to the central nervous system via mechanisms including changes in the expression of receptors, calcium overload, oxidative stress and cell death. Excitotoxicity is triggered by glutamate binding to receptors, including calcium permeable AMPA
Mirna Lechpammer et al.
Annals of neurology, 75(4), 608-612 (2014-03-07)
We followed a patient with manganese transporter deficiency due to homozygous SLC30A10 mutations from age 14 years until his death at age 38 years and present the first postmortem findings of this disorder. The basal ganglia showed neuronal loss, rhodanine-positive
N M Tun et al.
Letters in applied microbiology, 60(1), 20-26 (2014-10-07)
HOM6 is a major gene in the aspartate pathway which leads to biosynthesis of threonine and methionine. The phenotypes of the gene deletion mutant (hom6∆) in a variety of cultural conditions have previously provided meaningful insights into the biological roles of
Masakazu Nakamura et al.
Clinica chimica acta; international journal of clinical chemistry, 439, 185-190 (2014-12-03)
Accurate high-density lipoprotein cholesterol (HDL-C) measurements are important for management of cardiovascular diseases. The US Centers for Disease Control and Prevention (CDC) and Cholesterol Reference Method Laboratory Network (CRMLN) perform ultracentrifugation (UC) reference measurement procedure (RMP) to value assign HDL-C.
Yong-Seok Han et al.
International journal of cardiology, 198, 187-195 (2015-07-15)
Mesenchymal stem cells (MSCs) have the potential to differentiate into multiple cell lineages. Given this potential for tissue regeneration, MSC-based therapeutic applications have been considered in recent years. However, ischemia-induced apoptosis has been reported to be one of the main
Wynne Q Zhang et al.
Neuropharmacology, 90, 1-8 (2014-12-03)
Clinical evidence indicates brain serotonin (5-HT) stores and neurotransmission may be inadequate in subpopulations of individuals with autism, and this may contribute to characteristically impaired social behaviors. Findings that depletion of the 5-HT precursor tryptophan (TRP) worsens autism symptoms support
Tiebing Liu et al.
PloS one, 10(7), e0133622-e0133622 (2015-07-18)
The etiology and pathophysiology of schizophrenia remain obscure. This study explored the associations between schizophrenia risk and serum levels of 10 trace elements. A 1:1 matched case-control study was conducted and matched by age and sex. Blood samples were collected
Lisa M Yates et al.
Chembiochem : a European journal of chemical biology, 16(3), 415-423 (2015-02-03)
Protein pyrophosphorylation is emerging as a new post-translational modification, yet its role in cellular signaling remains poorly characterized. Important factors in determining the biological relevance of pyrophosphorylation include understanding the chemical and biochemical stability of the pyrophosphoryl group and elucidating
Haiping Zhao et al.
Stroke, 45(8), 2417-2424 (2014-07-12)
Ischemic postconditioning (IPostC) protects against ischemic brain injury. To date, no study has examined the role of T-LAK-cell-originated protein kinase (TOPK) in IPostC-afforded neuroprotection. We explored the molecular mechanism related with TOPK in antioxidant effect of IPostC against ischemia/reperfusion. Focal
Christian Nyrop Albers et al.
Water research, 83, 61-70 (2015-07-01)
Groundwater is an important drinking water resource. Yet, this resource is threatened by pollution from chemicals, such as pesticides and their degradation products. To investigate the potential for remediation of groundwater polluted by trace concentrations of the pesticide residue 2,6-dichlorobenzamide
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