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Yong-Seok Han et al.
International journal of cardiology, 198, 187-195 (2015-07-15)
Mesenchymal stem cells (MSCs) have the potential to differentiate into multiple cell lineages. Given this potential for tissue regeneration, MSC-based therapeutic applications have been considered in recent years. However, ischemia-induced apoptosis has been reported to be one of the main...
Majid Motaghinejad et al.
Fundamental & clinical pharmacology, 29(3), 299-309 (2015-04-08)
Chronic consumption of morphine induces physical dependency, anxiety, and neurodegeneration. In this study, morphine on its own has been used for the management of morphine-induced dependency, oxidative stress, and apoptosis. Forty-eight male rats were randomly divided into six groups. Rats...
Priyanka Singh et al.
Antonie van Leeuwenhoek, 108(3), 711-720 (2015-07-15)
The type strain DCY99(T) was isolated from soil collected from a ginseng field in Hwacheon, Republic of Korea. Strain DCY99(T) is Gram-negative, non-spore forming, motile, rod-shaped, and strictly aerobic. The bacteria grow optimally at 25-30 °C and pH 6.0-6.5. Phylogenetically...
Syed Moshfiqur Rahman et al.
Reproductive toxicology (Elmsford, N.Y.), 53, 68-74 (2015-04-02)
The essential element manganese (Mn) might be toxic at excess exposure. We assessed the impact of elevated Mn exposure through drinking water during pregnancy on birth size in a population-based cohort(n = 1695) in rural Bangladesh. Concentrations of water Mn...
Robert E Brennan et al.
BMC microbiology, 15, 99-99 (2015-05-13)
Periplasmically localized copper-zinc co-factored superoxide dismutase (SodC) enzymes have been identified in a wide range of Gram-negative bacteria and are proposed to protect bacteria from exogenously produced toxic oxygen radicals, which indicates the potential significance of a Coxiella burnetii SodC....
Johny Nicolas et al.
Environmental science. Processes & impacts, 17(11), 1952-1958 (2015-09-26)
The wide application and production of nanotechnology have increased the interest in studying the toxicity of nano- and micro-sized particles escaping into air from various aspects of the production process. Metal oxides (MOs) are one particular class of particles that...
Qi Ye et al.
Environmental toxicology and pharmacology, 40(1), 333-341 (2015-07-21)
Manganese in excess promotes unstable emotional behavior. Our previous study showed that olfactory manganese uptake into the brain is altered in Hfe(-/-) mice, a model of iron overload hemochromatosis, suggesting that Hfe deficiency could modify the neurotoxicity of airborne manganese....
Wynne Q Zhang et al.
Neuropharmacology, 90, 1-8 (2014-12-03)
Clinical evidence indicates brain serotonin (5-HT) stores and neurotransmission may be inadequate in subpopulations of individuals with autism, and this may contribute to characteristically impaired social behaviors. Findings that depletion of the 5-HT precursor tryptophan (TRP) worsens autism symptoms support...
Julia E Martin et al.
PLoS genetics, 11(3), e1004977-e1004977 (2015-03-17)
Escherichia coli does not routinely import manganese, but it will do so when iron is unavailable, so that manganese can substitute for iron as an enzyme cofactor. When intracellular manganese levels are low, the cell induces the MntH manganese importer...
Yassine Chtourou et al.
Environmental toxicology, 29(10), 1147-1154 (2013-01-23)
Metal toxicity may occur after exposure from many sources. Oxidative stress is thought to be involved in manganese-induced toxicity and leads to various health disorders. Silymarin (SIL), a natural flavonoid, has been reported to have many benefits and medicinal properties....
Tao Guo et al.
Scientific reports, 5, 8016-8016 (2015-01-27)
Bone homeostasis is maintained by the balance of osteoblasts (OBs) and osteoclasts (OCs). Increased activity of OCs not only contributes to pathological bone resorption, such as osteoporosis and periodontitis, but also is responsible for physiological conditions like orthodontic tooth movement...
Nicholas Cox et al.
Science (New York, N.Y.), 345(6198), 804-808 (2014-08-16)
The photosynthetic protein complex photosystem II oxidizes water to molecular oxygen at an embedded tetramanganese-calcium cluster. Resolving the geometric and electronic structure of this cluster in its highest metastable catalytic state (designated S3) is a prerequisite for understanding the mechanism...
Xiang Sheng et al.
Biochemistry, 53(27), 4455-4466 (2014-06-26)
Pyruvate carboxylase (PC) catalyzes the carboxylation of pyruvate to produce oxaloacetate. Its activity is directly related to insulin release and thus PC has recently attracted great interest as a potential target for diabetes treatment. In this article, the catalytic mechanism...
Y Chen et al.
Free radical research, 49(10), 1275-1284 (2015-06-30)
Mitochondrial oxidative damage is hypothesized to contribute to the pathogenesis of chronic cholestatic liver diseases. Melatonin, an indolamine synthesized in the pineal gland, shows a wide range of physiological functions, and is under clinical investigation for expanded applications. Melatonin has...
M W Roomi et al.
International journal of oncology, 44(3), 986-992 (2014-01-01)
Strong clinical and experimental evidence demonstrates association of elevated levels of matrix metalloproteinase MMP-9 with cancer progression, metastasis and shortened patient survival, as it plays a key role in tumor cell invasion and metastasis by digesting the basement membrane and...
Tiebing Liu et al.
PloS one, 10(7), e0133622-e0133622 (2015-07-18)
The etiology and pathophysiology of schizophrenia remain obscure. This study explored the associations between schizophrenia risk and serum levels of 10 trace elements. A 1:1 matched case-control study was conducted and matched by age and sex. Blood samples were collected...
Renaud Persoons et al.
Toxicology letters, 231(2), 135-141 (2014-09-17)
Welding fumes contain various toxic metals including chromium (Cr), nickel (Ni) and manganese (Mn). An assessment of the risk to health of local and systemic exposure to welding fumes requires the assessment of both external and internal doses. The aims...
Wangning Yu et al.
PloS one, 9(10), e110319-e110319 (2014-10-22)
Saccharomonospora viridis is a thermophilic actinomycete that may have biotechnological applications because of its dye decolorizing activity, though the enzymatic oxidative system responsible for this activity remains elusive. Bioinformatic analysis revealed a DyP-type peroxidase gene in the genome of S....
Lisa M Yates et al.
Chembiochem : a European journal of chemical biology, 16(3), 415-423 (2015-02-03)
Protein pyrophosphorylation is emerging as a new post-translational modification, yet its role in cellular signaling remains poorly characterized. Important factors in determining the biological relevance of pyrophosphorylation include understanding the chemical and biochemical stability of the pyrophosphoryl group and elucidating...
Haiping Zhao et al.
Stroke, 45(8), 2417-2424 (2014-07-12)
Ischemic postconditioning (IPostC) protects against ischemic brain injury. To date, no study has examined the role of T-LAK-cell-originated protein kinase (TOPK) in IPostC-afforded neuroprotection. We explored the molecular mechanism related with TOPK in antioxidant effect of IPostC against ischemia/reperfusion. Focal...
San Zeng et al.
Pharmaceutical research, 32(8), 2548-2558 (2015-02-13)
Citral is composed of a random mixture of two geometric stereoisomers geranial (trans-citral) and neral (cis-citral) yet few studies have directly compared their in vivo antitumor properties. A micelle formulation was therefore developed. Geranial and neral were synthesized. Commercially-purchased citral...
M Sidoryk-Wegrzynowicz et al.
Journal of internal medicine, 273(5), 466-477 (2013-01-31)
Manganese (Mn) is an essential trace element that is required for maintaining proper function and regulation of numerous biochemical and cellular reactions. Despite its essentiality, at excessive levels Mn is toxic to the central nervous system (CNS). Increased accumulation of...
M Waheed Roomi et al.
International journal of oncology, 45(2), 887-894 (2014-05-29)
Brain tumors are highly aggressive tumors that are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions that degrade the extracellular matrix (ECM) and basement membrane, allowing cancer cells to spread to distal organs. Proteases play a key...
Sang Jun Han et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(9), 1497-1506 (2015-07-05)
Progression of acute kidney injury to chronic kidney disease (CKD) is associated with inadequate recovery of damaged kidney. Hydrogen sulfide (H2S) regulates a variety of cellular signals involved in cell death, differentiation and proliferation. This study aimed to identify the...
Gustavo F de Sousa Viana et al.
Toxicology letters, 231(2), 169-178 (2014-07-06)
Manganese (Mn), an essential element to humans, in excess can cause neurotoxic damage. So far, Mn exposure assessment has no ideal biomarker. This study aims to investigate the association between Mn exposure, using noninvasive biomarkers, and neuropsychological effects in environmentally...
Laura A Nelson et al.
Neuroscience letters, 591, 171-175 (2015-02-15)
In mammalian models it is well documented that the potent orexigenic factor, neuropeptide Y (NPY) causes preferential intake of high carbohydrate and fat diets; however, information on this is limited in non-mammalian species. The purpose of this study was to...
Aldo Nicosia et al.
BioMed research international, 2015, 437328-437328 (2015-02-24)
Due to anthropogenic activities the relative concentrations of cadmium and manganese have increased in the marine environment. Cephalopods are able to accumulate such metals and, as inhabitant of coastal waters, Octopus vulgaris is continuously exposed to anthropogenic activities. Since no...
Michael Challenor et al.
Biochimie, 112, 160-171 (2015-03-21)
Glutamate excitotoxicity contributes to damage following injury to the central nervous system via mechanisms including changes in the expression of receptors, calcium overload, oxidative stress and cell death. Excitotoxicity is triggered by glutamate binding to receptors, including calcium permeable AMPA...
Mirna Lechpammer et al.
Annals of neurology, 75(4), 608-612 (2014-03-07)
We followed a patient with manganese transporter deficiency due to homozygous SLC30A10 mutations from age 14 years until his death at age 38 years and present the first postmortem findings of this disorder. The basal ganglia showed neuronal loss, rhodanine-positive...
Biljana Macanovic et al.
Disease markers, 2015, 436236-436236 (2015-02-19)
Semen analysis is the cornerstone in the evaluation of male (in)fertility. However, there are men with normal semen tests but with impaired fertilizing ability, as well as fertile men with poor sperm characteristics. Thus, there is rising interest to find...
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