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Laura E Fredenburgh et al.
American journal of physiology. Lung cellular and molecular physiology, 309(8), L834-L846 (2015-09-01)
Inhaled carbon monoxide (CO) gas has therapeutic potential for patients with acute respiratory distress syndrome if a safe, evidence-based dosing strategy and a ventilator-compatible CO delivery system can be developed. In this study, we used a clinically relevant baboon model
Srinivasan V Narayanan et al.
Stroke, 46(6), 1626-1632 (2015-04-25)
Nuclear erythroid 2 related factor 2 (Nrf2) is an astrocyte-enriched transcription factor that has previously been shown to upregulate cellular antioxidant systems in response to ischemia. Although resveratrol preconditioning (RPC) has emerged as a potential neuroprotective therapy, the involvement of
Michael Challenor et al.
Biochimie, 112, 160-171 (2015-03-21)
Glutamate excitotoxicity contributes to damage following injury to the central nervous system via mechanisms including changes in the expression of receptors, calcium overload, oxidative stress and cell death. Excitotoxicity is triggered by glutamate binding to receptors, including calcium permeable AMPA
Mirna Lechpammer et al.
Annals of neurology, 75(4), 608-612 (2014-03-07)
We followed a patient with manganese transporter deficiency due to homozygous SLC30A10 mutations from age 14 years until his death at age 38 years and present the first postmortem findings of this disorder. The basal ganglia showed neuronal loss, rhodanine-positive
N M Tun et al.
Letters in applied microbiology, 60(1), 20-26 (2014-10-07)
HOM6 is a major gene in the aspartate pathway which leads to biosynthesis of threonine and methionine. The phenotypes of the gene deletion mutant (hom6∆) in a variety of cultural conditions have previously provided meaningful insights into the biological roles of
Melanie L Foster et al.
Toxicological sciences : an official journal of the Society of Toxicology, 145(2), 244-251 (2015-03-01)
Concerns exist as to whether individuals may be at greater risk for neurotoxicity following increased manganese (Mn) oral intake. The goals of this study were to determine the equivalence of 3 methods of oral exposure and the rate (mg Mn/kg/day)
Gursharan Kaur et al.
Journal of bacteriology, 196(14), 2587-2597 (2014-05-06)
Manganese is a micronutrient required for activities of several important enzymes under conditions of oxidative stress and iron starvation. In Escherichia coli, the manganese homeostasis network primarily constitutes a manganese importer (MntH) and an exporter (MntP), which are regulated by
Marcus K Giacci et al.
PloS one, 9(8), e104565-e104565 (2014-08-12)
Red/near-infrared irradiation therapy (R/NIR-IT) delivered by laser or light-emitting diode (LED) has improved functional outcomes in a range of CNS injuries. However, translation of R/NIR-IT to the clinic for treatment of neurotrauma has been hampered by lack of comparative information
Jean-Paul Otamonga et al.
Luminescence : the journal of biological and chemical luminescence, 30(5), 507-511 (2014-09-17)
In order to study the mechanism of the enhancement of solution chemiluminescence, the kinetics of the decay of the oxidant and the chemiluminescence emission were followed for oxidations by permanganate, manganese dioxide sol and Mn(3+) (aq) of glyoxylic acid, using
M Waheed Roomi et al.
International journal of oncology, 47(1), 370-376 (2015-05-23)
Colorectal, pancreatic and hepatic carcinomas are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions, allowing cancer cells to spread to distal organs. These and other proteases, such as uPA, play a key role in tumor cell invasion
Gustavo F de Sousa Viana et al.
Toxicology letters, 231(2), 169-178 (2014-07-06)
Manganese (Mn), an essential element to humans, in excess can cause neurotoxic damage. So far, Mn exposure assessment has no ideal biomarker. This study aims to investigate the association between Mn exposure, using noninvasive biomarkers, and neuropsychological effects in environmentally
Laura A Nelson et al.
Neuroscience letters, 591, 171-175 (2015-02-15)
In mammalian models it is well documented that the potent orexigenic factor, neuropeptide Y (NPY) causes preferential intake of high carbohydrate and fat diets; however, information on this is limited in non-mammalian species. The purpose of this study was to
Zhen-Ying Qin et al.
Experimental biology and medicine (Maywood, N.J.), 239(12), 1567-1574 (2014-06-07)
We previously proposed that LYR motif containing 1 (LYRM1)-induced mitochondrial reactive oxygen species (ROS) production contributes to obesity-related insulin resistance. Metformin inhibits ROS production and promotes mitochondrial biogenesis in specific tissues. We assessed the effects of metformin on insulin resistance
Haiping Zhao et al.
The FEBS journal, 281(19), 4411-4420 (2014-07-30)
T-LAK-cell-originated protein kinase (TOPK), a MAPKK-like kinase, is crucial for neural progenitor cell proliferation; however, the function of TOPK and the molecular mechanism underlying cerebral ischemia-reperfusion injury remains unknown. Therefore, we investigated the role of TOPK in experimental stroke. Sprague-Dawley
Rajbir Kaur et al.
Journal of toxicology and environmental health. Part A, 78(6), 388-396 (2015-03-04)
This study examined the impact of municipal wastewater on scale morphology of freshwater fish Labeo rohita. Fish were exposed to sublethal concentrations (17.7, 26.6, or 35.4%) of municipal wastewater for durations of 15, 30, and 60 d. Recovery experiments were
Karin Tuschl et al.
International review of neurobiology, 110, 277-312 (2013-11-12)
Manganese (Mn) is an essential trace metal that is pivotal for normal cell function and metabolism. Its homeostasis is tightly regulated; however, the mechanisms of Mn homeostasis are poorly characterized. While a number of proteins such as the divalent metal
Leiming Wang et al.
PloS one, 10(5), e0127773-e0127773 (2015-05-27)
Manganese-enhanced magnetic resonance imaging (MEMRI) is a powerful technique for assessing the functional connectivity of neurons within the central nervous system. Despite the widely held proposition that MEMRI signal is dependent on neuronal activity, few studies have directly tested this
Jie Liu et al.
Environmental monitoring and assessment, 186(4), 2269-2279 (2013-11-26)
Revegetation and ecological restoration of a Mn mineland are important concerns in southern China. To determine the major constraints for revegetation and select suitable plants for phytorestoration, pedological and botanical characteristics of a Mn mine in Guangxi, southern China were
Rajbir Kaur et al.
Environmental toxicology and pharmacology, 39(2), 747-757 (2015-02-28)
The present study was aimed to evaluate the effect of municipal wastewater of Tung Dhab drain on morphology of scale melanophores in freshwater fish Labeo rohita (Ham.). Chronic, non-renewal toxicity tests were performed with sub lethal concentrations (17.7, 26.6 and
Esra Yıldız et al.
Food chemistry, 194, 143-148 (2015-10-17)
A new, simple and rapid coprecipitation method has been developed to separate and preconcentrate traces of Co(II), Cu(II), Fe(III), Pb(II) and Mn(II) in different samples prior to their determinations by flame atomic absorption spectrometry (FAAS). 2-[(E)-(8-hydroxy-2-methylquinolin-5-yl) diazenyl] benzoic acid (QAN)
Valeria C Culotta et al.
Antioxidants & redox signaling, 19(9), 933-944 (2012-12-20)
Antioxidant enzymes are thought to provide critical protection to cells against reactive oxygen species (ROS). However, many organisms can fully compensate for the loss of such enzymatic defenses by accumulating metabolites and Mn²⁺, which can form catalytic Mn-antioxidants. Accumulated metabolites
A Nasser et al.
Chemosphere, 107, 175-179 (2013-12-18)
DCP (2,4-dichlorophenol) is the key-intermediate in the synthesis of some widely used pesticides and is an EPA priority pollutant. The mechanochemical breakdown of DCP loaded on birnessite (δ-MnO2), montmorillonite saturated with Na(+) or Cu(2+) and hematite was investigated. Mechanical force
Katarzyna Zabłocka-Słowińska et al.
Postepy higieny i medycyny doswiadczalnej (Online), 66, 549-553 (2012-08-28)
Manganese (Mn) is an essential trace element, necessary for development and growth of the organism. The adequate content of this element in the body determines proper metabolism of amino acids, cholesterol and carbohydrates. This mineral influences activity of several enzymes
Shih-Hsin Chiu et al.
Journal of virology, 88(9), 4962-4975 (2014-02-21)
Epstein-Barr virus (EBV) lytic replication involves complex processes, including DNA synthesis, DNA cleavage and packaging, and virion egress. These processes require many different lytic gene products, but the mechanisms of their actions remain unclear, especially for DNA cleavage and packaging.
Amina Habbeche et al.
Journal of bioscience and bioengineering, 117(4), 413-421 (2013-10-22)
An extracellular thermostable keratinase (KERAK-29) was purified and biochemically characterized from a thermophilic actinomycete Actinomadura keratinilytica strain Cpt29 newly isolated from Algerian poultry compost. The isolate exhibited high keratinase production when grown in chicken feather meal media (24,000 U/ml). Based
Daiana Silva Avila et al.
Metal ions in life sciences, 13, 199-227 (2014-01-29)
Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and
Michael Joe Vaughan et al.
Microbial ecology, 70(1), 175-187 (2015-01-23)
Research on the distribution and structure of fungal communities in caves is lacking. Kartchner Caverns is a wet and mineralogically diverse carbonate cave located in an escarpment of Mississippian Escabrosa limestone in the Whetstone Mountains, Arizona, USA. Fungal diversity from
Darina Schelonka et al.
Photochemistry and photobiology, 91(5), 1071-1077 (2015-05-23)
ZnO doped with Cr, Mn, Fe, Co, Ni and Cu was prepared by homogeneous hydrolysis of sulfates with urea. The samples were annealed at various temperatures and characterized by X-ray powder diffraction, UV/VIS reflectance spectroscopy, BET (Brunauer-Emmet-Teller) surface area and
Ankur Datta et al.
American journal of physiology. Lung cellular and molecular physiology, 309(4), L369-L377 (2015-06-21)
Animal models demonstrate that exposure to supraphysiological oxygen during the neonatal period compromises both lung and pulmonary vascular development, resulting in a phenotype comparable to bronchopulmonary dysplasia (BPD). Our prior work in murine models identified postnatal maturation of antioxidant enzyme
Anansa S Ahmed et al.
Scientific reports, 5, 13773-13773 (2015-09-09)
Multifunctional materials inspired by biological structures have attracted great interest, e.g. for wearable/ flexible "skin" and smart coatings. A current challenge in this area is to develop an artificial material which mimics biological skin by simultaneously displaying color change on
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