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Klas Gustafson et al.
Acta orthopaedica, 85(4), 348-354 (2014-06-17)
Metal-on-metal (MOM) total hip arthroplasties were reintroduced because of the problems with osteolysis and aseptic loosening related to polyethylene wear of early metal-on-polyethylene (MOP) arthroplasties. The volumetric wear rate has been greatly reduced with MOM arthroplasties; however, because of nano-size...
Karan M Shah et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(1), 114-121 (2014-09-25)
Cobalt and chromium species are released in the local tissues as a result of tribo-corrosion, and affect bone cell survival and function. However we have little understanding of the mechanisms of cellular entry, intracellular distribution, and speciation of the metals...
O Lainiala et al.
The bone & joint journal, 96-B(12), 1610-1617 (2014-12-03)
We conducted a retrospective study to assess the prevalence of adverse reactions to metal debris (ARMD) in patients operated on at our institution with metal-on-metal (MoM) total hip replacements with 36 mm heads using a Pinnacle acetabular shell. A total...
Aya Watanabe et al.
Clinical science (London, England : 1979), 126(9), 671-678 (2013-11-22)
In the present study we sought to determine the effect of CoCl2, an inhibitor of PHD (prolyl hydroxylase domain protein), on the development of AAA (abdominal aortic aneurysm). AAA was induced in C57BL/6 mice by periaortic application of CaCl2 (AAA...
S Dianat et al.
Chemico-biological interactions, 215, 25-32 (2014-03-13)
The parent and nanosized starch, and lipid encapsulated K6[SiW11O39Co(H2O)]·nH2O (abbreviated as SEP, LEP and SiW11Co, respectively), as potent antitumor candidates, were synthesized and characterized by FT-IR spectroscopy, ICP, TG analysis, SEM and TEM images. The results show that the SiW11Co...
Guang Jin et al.
Surgery, 156(2), 221-228 (2014-06-22)
Therapeutic hypothermia and histone deacetylase inhibitors, such as valproic acid (VPA), independently have been shown to have neuroprotective properties in models of cerebral ischemic and traumatic brain injury. However, the depth of hypothermia and the dose of VPA needed to...
F Barras et al.
Metallomics : integrated biometal science, 3(11), 1130-1134 (2011-09-29)
Cobalt (Co) is present in trace amounts in the environment but it can be toxic when it accumulates in cells. The question of how Co produces its toxic effects and how living organisms protect themselves from, and resist to, such...
Kenneth M Unice et al.
Chemico-biological interactions, 216, 53-74 (2014-04-15)
An updated biokinetic model for human exposures to cobalt (Co) was developed based on a comprehensive set of human pharmacokinetics data collected from five male and five female volunteers who ingested ∼1 mg Co/day of a Co supplement for 3...
Lars Ole Simonsen et al.
The Science of the total environment, 432, 210-215 (2012-06-27)
Cobalt metabolism and toxicology are summarized. The biological functions of cobalt are updated in the light of recent understanding of cobalt interference with the sensing in almost all animal cells of oxygen deficiency (hypoxia). Cobalt (Co(2+)) stabilizes the transcriptional activator...
Emmanuel Thienpont et al.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 21(3), 636-640 (2012-04-11)
Hypersensitivity to metallic implants remains relatively unpredictable and poorly understood. Although 20-25 % of total joint arthroplasty patients develop metal sensitivity, only a few highly susceptible persons (<1 %) exhibit symptoms. We present a case report of a fifty-two-year-old woman with a...
Dalia Nayak et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 65(8), 891-896 (2007-05-29)
Heavy ion activation of natural cobalt foil with 84MeV (12)C results in the formation of no-carrier-added (nca) (66,67)As radionuclides, along with their corresponding decay products, (66,67)Ge and (66,67)Ga, in the matrix. Because arsenic and germanium radionuclides are short-lived, after a...
Mak A Saito et al.
Science (New York, N.Y.), 345(6201), 1173-1177 (2014-09-06)
Marine primary productivity is strongly influenced by the scarcity of required nutrients, yet our understanding of these nutrient limitations is informed by experimental observations with sparse geographical coverage and methodological limitations. We developed a quantitative proteomic method to directly assess...
K Praveena et al.
Journal of nanoscience and nanotechnology, 14(6), 4371-4376 (2014-04-18)
The Cobalt ferrite (CoFe2O4) powders were synthesized by Co-precipitation method. The as prepared ferrite powders were incorporated into a polyaniline matrix at various volumetric ratios. The as prepared composites of ferrite and polyaniline powders were characterized using X-ray diffraction (XRD)...
Brent L Finley et al.
Journal of toxicology and environmental health. Part B, Critical reviews, 15(8), 493-523 (2012-12-04)
Cobalt (Co) is an essential component of vitamin B(12). As with all metals, at sufficiently high doses, Co may exert detrimental effects on different organ systems, and adverse responses have been observed in animals, patients undergoing Co therapy, and workers...
Kazuhiro Yamada
Metal ions in life sciences, 13, 295-320 (2014-01-29)
The primarily function of cobalt in humans is based on its role in cobalamin (Cbl, vitamin B12). Therefore, this chapter will focus on the physiological roles of Cbl and the importance of cobalt in human health. Cbl acts as the...
Anthony F Pizon et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 9(4), 416-417 (2013-11-22)
Prosthetic hip-associated cobalt toxicity (PHACT) is gaining recognition due to the use of metal-on-metal total hip replacements. Identifying true toxicity from merely elevated cobalt levels can be extremely difficult due to the lack of available data. An extensive review of...
Juliane Fritzsche et al.
Clinical orthopaedics and related research, 470(8), 2325-2331 (2012-06-14)
Metal-on-metal bearings frequently are used in young patients leading to the concern that disseminated metals such as chromium (Cr) and cobalt (Co) as the main constituents could affect pregnancies. We describe a 41-year-old patient with bilateral metal-on-metal hip arthroplasties, a...
Mehmet Kardas et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 15-23 (2014-06-26)
High concentrations of heavy metals can be toxic for bacteria. However, after prolonged exposure, bacteria can become acclimated and begin to be able to grow in the presence of heavy metals. Acclimation can involve alterations of metabolism and molecular structures....
Andrea L Armstead et al.
Toxicology and applied pharmacology, 278(1), 1-8 (2014-04-22)
Tungsten carbide cobalt (WC-Co) has been recognized as a workplace inhalation hazard in the manufacturing, mining and drilling industries by the National Institute of Occupational Safety and Health. Exposure to WC-Co is known to cause "hard metal lung disease" but...
Qun Qian et al.
Mini reviews in medicinal chemistry, 13(6), 802-813 (2013-04-03)
Cross-coupling of alkyl halides with alkenes leading to Heck-type and addition products is summarized. The development of Heck reaction with aliphatic halides although has made significant progress in the past decade and particularly recently, it was much less explored in...
Sooim Shin et al.
Biochimica et biophysica acta, 1837(10), 1595-1601 (2014-05-27)
The 6×-Histidine tag which is commonly used for purification of recombinant proteins was converted to a catalytic redox-active center by incorporation of Co(2+). Two examples of the biological activity of this engineered protein-derived cofactor are presented. After inactivation of the...
Marie C Heffern et al.
Current opinion in chemical biology, 17(2), 189-196 (2012-12-29)
Inorganic complexes are versatile platforms for the development of potent and selective pharmaceutical agents. Cobalt possesses a diverse array of properties that can be manipulated to yield promising drug candidates. Investigations into the mechanism of cobalt therapeutic agents can provide...
Hao-Di Wu et al.
Journal of nanoscience and nanotechnology, 14(6), 4097-4100 (2014-04-18)
Cocrystal nanofibres of cobalt octaethylporphyrin and tetracyanoquinodimethane were prepared by a facile solution method and fully characterized by SEM, AFM, XRD, Raman, EDX, and UV-vis-NIR. The as-prepared cocrystal nanofibres had smooth surfaces and uniform dimension. When incorporated into prototype devices...
Karl Ap Payne et al.
Nature, 517(7535), 513-516 (2014-10-21)
Organohalide chemistry underpins many industrial and agricultural processes, and a large proportion of environmental pollutants are organohalides. Nevertheless, organohalide chemistry is not exclusively of anthropogenic origin, with natural abiotic and biological processes contributing to the global halide cycle. Reductive dehalogenases...
Tea Romih et al.
The Science of the total environment, 508, 76-84 (2014-12-02)
The aim of this study was to determine whether citric acid adsorbed onto cobalt ferrite (CoFe2O4) nanoparticles (NPs) influences the bioavailability of their constituents Co and Fe. Dissolution of Co and Fe was assessed by two measures: (i) in aqueous...
Shinji Tsuchida et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(8), 975-980 (2014-03-29)
We assessed whether heat shock protein 70 (HSP70) is involved in hypoxia inducible factor 1 alpha (HIF-1α)-dependent anabolic pathways in articular chondrocytes under hypoxic conditions. Primary rabbit chondrocytes were cultured under normoxia (20% oxygen condition) or hypoxia (1% oxygen condition)....
J J Jacobs et al.
The Journal of arthroplasty, 29(4), 668-669 (2014-03-25)
Mechanically assisted crevice corrosion (MACC) at metal/metal modular junctions in which at least one of the components is fabricated from cobalt-chromium alloy, has reemerged as a potential clinically significant complication in total hip arthroplasty. The clinical manifestation of MACC may...
Caroline Ann Lim et al.
Documenta ophthalmologica. Advances in ophthalmology, 130(1), 43-48 (2014-11-09)
The effect of elevated serum cobalt on the human visual system has not yet been established. In light of recent reports of visual problems with elevated cobalt in association with hip prostheses, this review examines the literature for evidence regarding...
Matej Adámik et al.
Biochemical and biophysical research communications, 456(1), 29-34 (2014-12-03)
Site-specific DNA recognition and binding activity belong to common attributes of all three members of tumor suppressor p53 family proteins: p53, p63 and p73. It was previously shown that heavy metals can affect p53 conformation, sequence-specific binding and suppress p53...
Dennis J Paustenbach et al.
Clinical toxicology (Philadelphia, Pa.), 52(2), 98-112 (2013-11-22)
INTRODUCTION. There has been some recent concern regarding possible systemic health effects resulting from elevated blood cobalt concentrations in patients with cobalt containing hip implants. To date there are no blood cobalt criteria to help guide physicians when evaluating an...
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