显示 1-30 共 40 条结果 关于 "GF63970498"
Simone Vecchi et al.
Journal of pharmaceutical sciences, 101(1), 17-20 (2011-09-16)
Aluminum (Al) salt-based adjuvants are present in a large variety of licensed vaccines and their use is widely considered for formulations in clinical trials. Although the regulatory agencies have clearly stated the acceptable levels of Al salts in vaccines for...
Pulmonary fibrosis associated with aluminum trihydrate (Corian) dust.
Paul Gannon et al.
The New England journal of medicine, 370(22), 2156-2157 (2014-05-30)
Ryan J Mailloux et al.
Experimental cell research, 317(16), 2231-2238 (2011-07-27)
Aluminum (Al) is a metal toxin that has been implicated in the etiology of a number of diseases including Alzheimer's, Parkinson's, dialysis encephalopathy, and osteomalacia. Al has been shown to exert its effects by disrupting lipid membrane fluidity, perturbing iron...
J R Walton
Journal of Alzheimer's disease : JAD, 29(2), 255-273 (2012-02-15)
Most humans living in industrialized societies are routinely exposed to bioavailable aluminum salts in the form of additives-in commercially-prepared foods, alum-clarified drinking water, certain pharmaceuticals, sunscreens, and other topical applications. Minute amounts of this aluminum are absorbed into the circulation....
Vesa Riihimäki et al.
Critical reviews in toxicology, 42(10), 827-853 (2012-09-28)
Exposure to aluminum at work is widespread, and people are exposed to several species of aluminum, which differ markedly as to the kinetics and toxicity. Especially welding of aluminum is widely applied and continuously expanding. Inhalation of fine particles of...
C C Simões et al.
Genetics and molecular research : GMR, 11(3), 1949-1957 (2012-08-08)
Aluminum (Al) toxicity restricts root growth and agricultural yield in acid soils, which constitute approximately 40% of the potentially arable lands worldwide. The two main mechanisms of Al tolerance in plants are internal detoxification of Al and its exclusion from...
Todd D Terhune et al.
Journal of immunotoxicology, 10(2), 210-222 (2012-09-13)
Aluminum-containing adjuvants increase the effectiveness of vaccination, but their ability to augment immune responsiveness also carries the risk of eliciting non-target responses, especially in genetically susceptible individuals. This study reviews the relevant actions of aluminum adjuvants and sources of genetic...
Giovanni Muto et al.
Urology, 83(4), 851-855 (2014-02-20)
To determine whether thulium:yttrium-aluminum-garnet laser resection of bladder tumor (TmLRBT) may offer advantages over classic resection. From April 2011 to September 2012, 55 consecutive patients newly diagnosed with clinical stage ≤T2 bladder cancer were enrolled in a prospective study on TmLRBT....
Lisa A Cowan et al.
American journal of ophthalmology, 159(1), 138-143 (2014-10-14)
To illustrate 3 cases of chronic open-angle glaucoma secondary to the neodymium-yttrium-aluminum-garnet (Nd:YAG) laser vitreolysis procedure for symptomatic vitreous floaters. Observational case series. Location of the study was the Doheny Eye Institute. Three eyes of 2 patients who developed chronic...
Jian-Yong Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), 6503-6508 (2014-04-15)
Aluminum (Al) toxicity is a major constraint for crop production on acid soils which compose ∼ 40% of arable land in the tropics and subtropics. Rice is the most Al-tolerant cereal crop and offers a good model for identifying Al...
Aifeng Liu et al.
Journal of nanoscience and nanotechnology, 14(6), 4584-4589 (2014-04-18)
Ordered hexagonal mesoporous aluminosilicates with lower Si/Al ratio below 5 have been successfully synthesized via the co-assembly of preformed aluminosilicate precursors with Gemini surfactant [C12H25N+(CH3)2(CH2)6N+(CH3)2C12H25] x 2Br(-) as the template. Powder X-ray diffraction, transmission electron microscopy, scanning electron microscopy, N2...
Huyi He et al.
Plant signaling & behavior, 7(4), 469-471 (2012-04-14)
Nitric oxide (NO) is involved, together with plant hormones, in the adaptation to Al stress in plants. However, the mechanism by which NO and plant hormones interplay to improve Al tolerance are still unclear. We have recently shown that patterns...
Y Z Zhu et al.
Environmental toxicology and pharmacology, 35(1), 82-87 (2013-01-01)
Aluminum (Al) is widely used in daily life and will lead to environmental release and exposure. The toxicity of Al had been documented, and which attracted a growing concern on human and animal health. The immune system appears to be...
M W Calfee et al.
Letters in applied microbiology, 61(5), 418-422 (2015-09-04)
Five commercially available liquid antimicrobials were evaluated for their ability to decontaminate common environmental surface materials, contaminated with Burkholderia pseudomallei, using a spray-based disinfectant delivery procedure. Tests were conducted at both an ambient temperature (c. 20°C) and a lower temperature...
Pulmonary fibrosis associated with aluminum trihydrate (Corian) dust.
Ganesh Raghu et al.
The New England journal of medicine, 370(22), 2154-2156 (2014-05-30)
Daeryong Park et al.
Environmental monitoring and assessment, 187(1), 4095-4095 (2014-11-17)
Eighteen sites impacted by abandoned mine drainage (AMD) in Pennsylvania were sampled and measured for pH, acidity, alkalinity, metal ions, and sulfate. This study compared the accuracy of four acidity calculation methods with measured hot peroxide acidity and identified the...
Rejane C Marques et al.
Environmental pollution (Barking, Essex : 1987), 187, 130-135 (2014-02-04)
We studied neurodevelopment in infants from two communities. Children living in the vicinity of tin-ore kilns and smelters - TOKS; n = 51) were compared to children from a fishing village (Itapuã; n = 45). Mean hair-Hg (HHg) concentrations were significantly higher in Itapuã...
Sungwon Han et al.
Cell biology and toxicology, 29(2), 75-84 (2013-03-07)
Metal pollutants are a global health risk due to their ability to contribute to a variety of diseases. Aluminum (Al), a ubiquitous environmental contaminant is implicated in anemia, osteomalacia, hepatic disorder, and neurological disorder. In this review, we outline how...
Yiyan Zhang et al.
Bulletin of environmental contamination and toxicology, 93(1), 78-83 (2014-03-13)
An enhanced Al(3+) tolerance has been observed in ethylene insensitive mutant ein2-1 and salicylic acid insensitive mutant npr1-1 of Arabidopsis. However, we found that the tolerant phenotype of ein2-1 and npr1-1 under Al stress was dependent on NPR and EIN...
Eric J B von Wettberg et al.
Molecular ecology, 23(24), 5931-5933 (2014-12-24)
Long-term ecological experiments provide unique opportunities to observe the effects of natural selection. The Park Grass Experiment at Rothamsted Experiment Station in Hertfordshire, UK, is the longest running ecological experiment that incorporates fertilization treatments and has been ongoing since 1856....
K I Bohuts'ka et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 60(1), 91-97 (2014-05-09)
Taking into consideration the nanodimension of functional components of living cells, the application of nanotechnology in the biomedical purposes is currently an urgent task. One of these directions is the use of aluminum nanoparticles for molecular diagnostics, targeted delivery of...
Steffen Rausch et al.
Urology, 85(1), 182-188 (2014-12-23)
To evaluate complications and functional outcome and to identify patient-associated risk factors, we analyzed consecutive patients undergoing thulium:yttrium-aluminum-garnet laser enucleation of the prostate (ThuLEP) in our department. A total of 234 patients were prospectively analyzed. Preoperative data, postoperative complications, and...
Wilberth Poot-Poot et al.
IUBMB life, 63(10), 864-872 (2011-09-10)
An early response of plants to environmental signals or abiotic stress suggests that the phospholipid signaling pathway plays a pivotal role in these mechanisms. The phospholipid signaling cascade is one of the main systems of cellular transduction and is related...
Jicheng Hu et al.
Environmental pollution (Barking, Essex : 1987), 193, 6-12 (2014-07-02)
Unintentionally produced persistent organic pollutants (UP-POPs) were determined in ambient air from around five secondary non-ferrous metal processing plants in China, to investigate the potential impacts of the emissions of these plants on their surrounding environments. The target compounds were...
Zulfiqar Ahmad et al.
Biochemistry, 53(47), 7376-7385 (2014-11-07)
This paper describes the role of α-subunit VISIT-DG sequence residue αThr-349 in the catalytic sites of Escherichia coli F1Fo ATP synthase. X-ray structures show the highly conserved αThr-349 in the proximity (2.68 Å) of the conserved phosphate binding residue βR182...
C A Shaw et al.
Immunologic research, 56(2-3), 304-316 (2013-04-24)
We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous...
Stephen C Bondy
Toxicology, 315, 1-7 (2013-11-06)
Aluminum is one of the most common metal elements in the earth's crust. It is not an essential element for life and has commonly been thought of as a rather inert and insoluble mineral. Therefore, it has often been regarded...
M A Santos et al.
Current medicinal chemistry, 19(17), 2773-2793 (2012-03-30)
This review is focused on recent developments on hydroxypyri(mi)dines, as aluminum and actinide chelating agents to combat the toxicity due to accumulations of these metal ions in human body resulting from excessive metal exposure. After a brief update revision of...
Maire E Percy et al.
Journal of inorganic biochemistry, 105(11), 1505-1512 (2011-11-22)
In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later...
R H Kadam et al.
Journal of nanoscience and nanotechnology, 14(6), 4101-4107 (2014-04-18)
Ferrite samples with a chemical formula Co0.5Ni0.5Al(x)Fe(2-x)O4 (where x = 0.0, 0.25, 0.5, 0.75 and 1.0) were synthesized by sol-gel auto-combustion method. The synthesized samples were annealed at 600 degrees C for 4 h. An analysis of X-ray diffraction (XRD)...

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