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Non-intravenous approaches to iron therapy in chronic kidney disease: will it improve the benefit-to-risk ratio?
Anatole Besarab
Nephrology news & issues, 28(2), 12-12 (2014-03-22)
Oliver M Theusinger
Praxis, 103(21), 1257-1262 (2014-10-12)
Blood transfusions are in general considered as lifesaving. Current data and evidence show, that blood transfusions are associated with increased morbidity and mortality, and this apparently dose-dependent. Basic research and results from randomized controlled trials show a causal relationship between
Crystal D Karakochuk et al.
The Journal of nutrition, 145(1), 134-142 (2014-12-21)
Anemia is common in Cambodian women. Potential causes include micronutrient deficiencies, genetic hemoglobin disorders, inflammation, and disease. We aimed to investigate factors associated with anemia (low hemoglobin concentration) in rural Cambodian women (18-45 y) and to investigate the relations between
Jun-Won Jang et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 59(12), 2503-2507 (2009-06-23)
Zero valent iron has been successfully used for the degradation of a wide range of contaminants. However, this reaction of using ZVI particle produces a large quantity of iron sludge. To solve the problem, we report the synthesis of self-organized
Koichiro Uto et al.
Journal of nanoscience and nanotechnology, 14(4), 3193-3201 (2014-04-17)
(Apo)ferritins are cage-shaped proteins which have recently received a great deal of attention because the inner cavity of the protein shell can be used as a size-restricted reaction field for the synthesis of nanomaterials. The biomineralization behavior and inorganic nanoparticle
Florence Lima et al.
Environmental and molecular mutagenesis, 55(3), 266-277 (2014-04-12)
DNA methylation is an epigenetic mechanism that drives phenotype and that can be altered by environmental exposures including radiation. The majority of human radiation exposures occur in a relatively low dose range; however, the biological response to low dose radiation
Vivek Kumar Srivastava et al.
The Biochemical journal, 463(1), 103-114 (2014-07-06)
Iron is an essential nutrient for all living organisms and human pathogens employ a battery of factors to scavenge iron from the high-affinity iron-binding host proteins. In the present study, we have elucidated, via a candidate gene approach, major iron
Lucie Y Guo et al.
Experimental eye research, 129, 31-37 (2014-12-03)
Age-related macular degeneration (AMD) is the most common cause of blindness among older adults in developed countries, and retinal iron accumulation may exacerbate the disease. Iron can upregulate the production of amyloid precursor protein (APP). Since amyloid-β (Aβ), a byproduct
Céline Termote et al.
Food and nutrition bulletin, 35(4), 458-479 (2015-02-03)
Wild foods and their actual and potential contributions to nutrition security have rarely been studied or considered in nutrition and conservation programs. To study the role of wild food biodiversity in achieving a cost reduction of a nutritionally adequate diet
Catherine F M Bowden et al.
Biochemistry, 53(14), 2286-2294 (2014-03-22)
The Isd (iron-regulated surface determinant) system is a multiprotein transporter that allows bacterium Staphylococcus aureus to take up iron from hemoglobin (Hb) during human infection. In this system, IsdB is a cell wall-anchored surface protein that contains two near iron
Sandra Isabel Escobar-Megchún et al.
Journal of water and health, 12(4), 722-726 (2014-12-05)
This study relates to a method for evaluating the degradation efficiency of Ascaris lumbricoides eggs through a Fenton reaction, using hydrogen peroxide (H2O2) at 100, 250, and 500 mg/L, ferrous sulfate (FeSO4) at 458 mg/L Fe(2+) and pH values of
Shuichi Sekine et al.
Toxicology and applied pharmacology, 282(3), 237-243 (2014-12-30)
Patients with long-lasting hepatitis C virus (HCV) infection are at major risk of hepatocellular carcinoma (HCC). Iron accumulation in the livers of these patients is thought to exacerbate conditions of oxidative stress. Transgenic mice that express the HCV core protein
Ewelina Łukaszyk et al.
Przeglad lekarski, 71(2), 95-97 (2014-07-16)
Subclinical inflammation is one of the key mechanisms responsible for the development and progression of chronic kidney disease. It may stem from uremia, ongoing inflammation in kidney as well as latent bacterial and viral infections. Inflammation also plays a significant
The role of intravenous iron for the treatment of restless legs syndrome.
Michael Auerbach
American journal of hematology, 89(10), 1016-1016 (2014-08-05)
Courtni E Allen et al.
Journal of bacteriology, 197(3), 553-562 (2014-11-19)
The use of hemin iron by Corynebacterium diphtheriae requires the DtxR- and iron-regulated ABC hemin transporter HmuTUV and the secreted Hb-binding protein HtaA. We recently described two surface anchored proteins, ChtA and ChtC, which also bind hemin and Hb. ChtA
James C Barton et al.
The American journal of the medical sciences, 349(1), 50-55 (2015-01-07)
Primary iron overload in African Americans has been reported predominantly from autopsy studies. We characterized hepatic iron phenotypes in 83 African Americans who underwent liver biopsy during the interval 1990 to 1995. We tabulated pathology report form data, iron grades
Satoshi Wakai et al.
Microbial ecology, 68(3), 519-527 (2014-05-28)
Elemental iodine is produced in Japan from underground brine (fossil salt water). Carbon steel pipes in an iodine production facility at Chiba, Japan, for brine conveyance were found to corrode more rapidly than those in other facilities. The corroding activity
[Cutting-edge of medicine; iron metabolism--recent findings].
Hideo Harigae
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 102(10), 2699-2704 (2014-01-10)
Alexander Liberman et al.
The Journal of surgical research, 190(2), 391-398 (2014-06-29)
High intensity-focused ultrasound (HIFU) is an alterative ablative technique currently being investigated for local treatment of breast cancer and fibroadenomas. Current HIFU therapies require concurrent magnetic resonance imaging monitoring. Biodegradable 500 nm perfluoropentane-filled iron-silica nanoshells have been synthesized as a sensitizing
V N Marty et al.
Radiation research, 182(6), 653-665 (2014-11-18)
The evaluation of potential health risks associated with neuronal exposure to space radiation is critical for future long duration space travel. The purpose of this study was to evaluate and compare the effects of low-dose proton and high-energy charged particle
Yukio Miyamoto et al.
AJR. American journal of roentgenology, 202(4), W400-W407 (2014-03-26)
The objective of our study was to compare the efficacy of contrast-enhanced ultrasound (CEUS) using the ultrasound contrast agent Sonazoid (perflubutane) with unenhanced ultrasound and supplementary contrast-enhanced MRI in the differential diagnosis (benign vs malignant) of focal breast lesions. The
S J Ford et al.
Annals of the Royal College of Surgeons of England, 96(4), 275-278 (2014-05-02)
The incidence of oesophageal adenocarcinoma (OAC) is rising dramatically and overall survival remains extremely poor. Iron has been shown to potentiate tumourigenesis in OAC, and iron chelation therapy demonstrates promise in vivo as an adjunct to neoadjuvant and palliative chemotherapy.
Oriana Marques et al.
Cancer letters, 347(1), 1-14 (2014-02-04)
Iron is an essential element and a critical component of molecules involved in energy production, cell cycle and intermediate metabolism. However, the same characteristic chemistry that makes it so biologically versatile may lead to iron-associated toxicity as a consequence of
Julia Steuber et al.
Nature, 516(7529), 62-67 (2014-12-05)
NADH oxidation in the respiratory chain is coupled to ion translocation across the membrane to build up an electrochemical gradient. The sodium-translocating NADH:quinone oxidoreductase (Na(+)-NQR), a membrane protein complex widespread among pathogenic bacteria, consists of six subunits, NqrA, B, C
M Pasalar et al.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 20(11), 726-731 (2015-01-21)
This study investigated the prevalence of iron-deficiency anaemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency and β-thalassaemia trait among Arab migrating nomad children in southern Islamic Republic of Iran. Blood samples were analysed from 134 schoolchildren aged < 18 years (51 males, 83
Nanda Kumar N Shanmugam et al.
Journal of immunology (Baltimore, Md. : 1950), 193(3), 1398-1407 (2014-06-29)
States of chronic inflammation such as inflammatory bowel disease are often associated with dysregulated iron metabolism and the consequent development of an anemia that is caused by maldistribution of iron. Abnormally elevated expression of the hormone hepcidin, the central regulator
Lucia Banci et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), 6203-6208 (2014-04-16)
Monothiol glutaredoxins play a crucial role in iron-sulfur (Fe/S) protein biogenesis. Essentially all of them can coordinate a [2Fe-2S] cluster and have been proposed to mediate the transfer of [2Fe-2S] clusters from scaffold proteins to target apo proteins, possibly by
Geochemistry. How sulfur beats iron.
Michael W Friedrich et al.
Science (New York, N.Y.), 344(6187), 974-975 (2014-05-31)
Pirkko Peuranpää et al.
Acta obstetricia et gynecologica Scandinavica, 93(7), 654-660 (2014-06-11)
To assess the impact of anemia and iron deficiency on health-related quality of life (HRQoL) in women treated for heavy menstrual bleeding (HMB). Secondary analysis of a randomized controlled trial. Five university hospitals in Finland. A total of 236 women
Mitchell R Olson et al.
Chemosphere, 114, 144-149 (2014-08-13)
Polychlorinated biphenyls (PCBs) are well-known for being hydrophobic and persistent in the environment. Although many treatment approaches have been demonstrated to result in degradation of PCBs in water or water/cosolvent systems, few examples exist where such approaches have been applied
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