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Carole Laffont et al.
PloS one, 10(1), e0116819-e0116819 (2015-01-07)
Cytokinins are phytohormones that regulate many developmental and environmental responses. The Medicago truncatula cytokinin receptor MtCRE1 (Cytokinin Response 1) is required for the nitrogen-fixing symbiosis with rhizobia. As several cytokinin signaling genes are modulated in roots depending on different biotic
Yong Wang et al.
Chemical biology & drug design, 84(6), 685-696 (2014-06-04)
Peptidoglycan glycosyltransferase (PGT) has been shown to be an important pharmacological target for the inhibition of bacterial cell wall biosynthesis. Structure-based virtual screening of about 3,000,000 commercially available compounds against the crystal structure of the glycosyltransferase (GT) domain of the
David Giganti et al.
Nature communications, 5, 4833-4833 (2014-09-11)
The Plasmodium subtilase SUB1 plays a pivotal role during the egress of malaria parasites from host hepatocytes and erythrocytes. Here we report the crystal structure of full-length SUB1 from the human-infecting parasite Plasmodium vivax, revealing a bacterial-like catalytic domain in
Robert A Bender
Microbiology and molecular biology reviews : MMBR, 76(3), 565-584 (2012-08-31)
The ability to degrade the amino acid histidine to ammonia, glutamate, and a one-carbon compound (formate or formamide) is a property that is widely distributed among bacteria. The four or five enzymatic steps of the pathway are highly conserved, and
George S Chuck et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), 18775-18780 (2014-12-17)
The separation of male and female flowers in maize provides the potential for independent regulation of traits that affect crop productivity. For example, tassel branch number controls pollen abundance and length of shedding time, whereas ear row number directly affects
S K Falahati-Pour et al.
Journal of applied microbiology, 118(4), 976-988 (2015-01-08)
Organophosphorus pesticides are widely used in agriculture. Accordingly, decontamination of these pesticides and their residual in environment is an important aim of researchers. One of the best approaches is enzymatic detoxification of these compounds with organophosphorus hydrolase (OPH). The immobilization
Xavier Brazzolotto et al.
The Biochemical journal, 460(1), 79-89 (2014-03-15)
Iron is an essential element for almost all organisms. In eukaryotes, it is mainly used in mitochondria for the biosynthesis of iron-sulfur clusters and haem group maturation. Iron is delivered into the mitochondrion by mitoferrins, members of the MCF (mitochondrial
Lingchao Gao et al.
Gene, 549(1), 70-76 (2014-07-20)
Coconut (Cocos nucifera L.) is an economically tropical fruit tree with special fatty acid compositions. The stearoyl-acyl carrier protein (ACP) desaturase (SAD) plays a key role in the properties of the majority of cellular glycerolipids. In this paper, a full-length
Jeffrey M Brown et al.
Journal of neurochemistry, 129(2), 275-283 (2013-11-26)
NMDA receptor hypofunction is hypothesized to contribute to cognitive deficits associated with schizophrenia. Since direct activation of NMDA receptors is associated with serious adverse effects, modulation of the NMDA co-agonists, glycine or D-serine, represents a viable alternative therapeutic approach. Indeed
Viswanathan Thiruselvam et al.
Biochemical and biophysical research communications, 446(4), 945-951 (2014-03-22)
RNA binding proteins control gene expression by the attenuation/antitermination mechanism. HutP is an RNA binding antitermination protein. It regulates the expression of hut operon when it binds with RNA by modulating the secondary structure of single-stranded hut mRNA. HutP necessitates
Fa-Cai Li et al.
Parasites & vectors, 7, 498-498 (2014-11-13)
Phosphoinositide 3-kinases (PI3Ks) are relatively conserved and important intracellular lipid kinases involved in signalling and other biological pathways. In the free-living nematode Caenorhabditis elegans, the heterodimeric form of PI3K consists of catalytic (AGE-1) and regulatory (AAP-1) subunits. These subunits are
Sunanda Margrett Williams et al.
The Journal of biological chemistry, 289(16), 11042-11058 (2014-02-28)
Dps (DNA-binding protein from starved cells) are dodecameric assemblies belonging to the ferritin family that can bind DNA, carry out ferroxidation, and store iron in their shells. The ferritin-like trimeric pore harbors the channel for the entry and exit of
Anna-Lena Henche et al.
Extremophiles : life under extreme conditions, 18(5), 905-913 (2014-08-12)
In Archaea, type IV prepilins and prearchaellins are processed by designated signal peptidase III (SPaseIII) prior to their incorporation into pili and the archaellum, respectively. These peptidases belong to the family of integral membrane aspartic acid proteases that contain two
Hui Y Yang et al.
Virology journal, 11, 165-165 (2014-09-17)
The antiviral therapy of chronic hepatitis B virus (HBV) infection pursues the dual goals, virological response (undetectable serum HBV DNA) and hepatitis B e antigen (HBeAg) serological response (serum HBeAg loss/seroconversion). It is relatively difficult, however, to realize the serological
Jiancheng Hu et al.
Molecular and cellular biology, 35(1), 264-276 (2014-10-29)
A new model of kinase regulation based on the assembly of hydrophobic spines has been proposed. Changes in their positions can explain the mechanism of kinase activation. Here, we examined mutations in human cancer for clues about the regulation of
Ivan Anastassov et al.
Journal of neurochemistry, 129(2), 249-255 (2013-11-30)
Our recent studies have shown that endogenous zinc, co-released with glutamate from the synaptic terminals of vertebrate retinal photoreceptors, provides a feedback mechanism that reduces calcium entry and the concomitant vesicular release of glutamate. We hypothesized that zinc feedback may
Patrick Lugenbiel et al.
PloS one, 10(3), e0116395-e0116395 (2015-03-17)
Atrial fibrillation (AF) and heart failure (HF) are two of the most common cardiovascular diseases. They often coexist and account for significant morbidity and mortality. Alterations in cellular Ca2+ homeostasis play a critical role in AF initiation and maintenance. This
Christine E Engeland et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(11), 1949-1959 (2014-08-27)
We hypothesized that the combination of oncolytic virotherapy with immune checkpoint modulators would reduce tumor burden by direct cell lysis and stimulate antitumor immunity. In this study, we have generated attenuated Measles virus (MV) vectors encoding antibodies against CTLA-4 and
Johanna Rajasärkkä et al.
Analytical and bioanalytical chemistry, 406(23), 5695-5702 (2014-05-13)
Bioluminescent Saccharomyces cerevisiae yeast-based bioreporters were used to monitor bisphenol A and other estrogenic chemicals in thermal paper samples collected mainly from Finland on two occasions in 2010/2011, and 2013. The bisphenol A-targeted (BPA-R) and the human oestrogen receptor (hERα)
Serena Rinaldo et al.
Journal of bacteriology, 197(8), 1525-1535 (2015-02-19)
The intracellular level of the bacterial secondary messenger cyclic di-3',5'-GMP (c-di-GMP) is determined by a balance between its biosynthesis and degradation, the latter achieved via dedicated phosphodiesterases (PDEs) bearing a characteristic EAL or HD-GYP domain. We here report the crystal
Susanne Klumpp et al.
Science signaling, 2(61), pe13-pe13 (2009-03-13)
Signaling by kinases and phosphatases that act on serine, threonine, and tyrosine residues of proteins is among the most extensively studied regulatory mechanisms in mammalian cells, and research focused in this area is ongoing. We are just beginning to appreciate
Eva M Fernandez et al.
PloS one, 10(1), e0117206-e0117206 (2015-01-23)
Intrinsically disordered proteins (IDPs) are abundant in complex organisms. Due to their promiscuous nature and their ability to adopt several conformations IDPs constitute important points of network regulation. The family of Brain Expressed and X-linked (Bex) proteins consists of 5
Junlei Sun et al.
Biochimica et biophysica acta, 1837(8), 1362-1375 (2014-04-22)
The axial ligands of the acceptor chlorophylls, A(0A) and A(0B), in Photosystem I are the Met sulfur atoms of M688(PsaA) and M668(PsaB). To determine the role of the Met, His variants were generated in Synechocystis sp. PCC 6803. Molecular dynamics
Junjie Zhao et al.
Biochemistry, 53(15), 2474-2482 (2014-03-29)
Dehaloperoxidase hemoglobin A (DHP A) is a multifunctional hemoglobin that appears to have evolved oxidative pathways for the degradation of xenobiotics as a protective function that complements the oxygen transport function. DHP A possesses at least two internal binding sites
Neha Sawhney et al.
Applied and environmental microbiology, 80(19), 6114-6125 (2014-07-27)
Methylglucuronoarabinoxylan (MeGAXn) from agricultural residues and energy crops is a significant yet underutilized biomass resource for production of biofuels and chemicals. Mild thermochemical pretreatment of bagasse yields MeGAXn requiring saccharifying enzymes for conversion to fermentable sugars. A xylanolytic bacterium, Paenibacillus
A T Da Poian et al.
Protein and peptide letters, 16(7), 779-785 (2009-07-16)
Membrane fusion is an essential step in the entry of enveloped viruses into their host cells, what makes it a potentially attractive target for viral inactivation approaches. Fusion is mediated by viral surface glycoproteins that undergo conformational changes triggered by
Vladimir Mishin et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(2), 344-352 (2014-07-26)
Microsomal enzymes generate H2O2 in the presence of NADPH. In this reaction, referred to as "oxidase" activity, H2O2 is generated directly or indirectly via the formation of superoxide anion. In the presence of redox active transition metals, H2O2 can form
Cecilia M Casadei et al.
Science (New York, N.Y.), 345(6193), 193-197 (2014-07-12)
Heme enzymes activate oxygen through formation of transient iron-oxo (ferryl) intermediates of the heme iron. A long-standing question has been the nature of the iron-oxygen bond and, in particular, the protonation state. We present neutron structures of the ferric derivative
Tetsuya Chujo et al.
PloS one, 9(6), e98737-e98737 (2014-06-04)
WRKY transcription factors and mitogen-activated protein kinase (MAPK) cascades have been shown to play pivotal roles in the regulation of plant defense responses. We previously reported that OsWRKY53-overexpressing rice plants showed enhanced resistance to the rice blast fungus. In this
Chaoyang Ma et al.
Journal of pharmaceutical and biomedical analysis, 105, 84-90 (2014-12-30)
An ultra-performance liquid chromatography-quadrupole time-of-flight-based metabolomic approach was developed to study influence of salidroside, an anti-fatigue ingredient from Rhoiola rosea, on urinary metabolic profiling of rats to a single dose of 180 mg/kg per day. Unsupervised principal component analysis (PCA)
页码 1 来自 6
页码 1 来自 6