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关键词:'J4750'
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Ilan Feine et al.
PloS one, 7(7), e41633-e41633 (2012-08-23)
Major circulation pathologies are initiated by oxidative insult expansion from a few injured endothelial cells to distal sites; this possibly involves mechanisms that are important to understanding circulation physiology and designing therapeutic management of myocardial pathologies. We tested the hypothesis
JNK signaling: regulation and functions based on complex protein-protein partnerships
Zeke A, et al.
Microbiology and Molecular Biology Reviews, 80(3), 793-835 (2016)
Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis
Stambe C, et al.
Kidney International, 64(6), 2121-2132 (2003)
Sarah Kraus et al.
International journal of molecular sciences, 21(22) (2020-11-19)
The key participants in G-protein-coupled receptor (GPCR) signaling are the mitogen-activated protein kinase (MAPK) signaling cascades. The mechanisms involved in the activation of the above cascades by GPCRs are not fully elucidated. The prototypical GPCR is the receptor for gonadotropin-releasing
Edward Kabara et al.
Frontiers in microbiology, 3, 215-215 (2012-07-27)
Mycobacterium avium subspecies paratuberculosis (MAP) is able to survive intracellularly in macrophages by preventing normal phagosome maturation processes utilized to destroy bacteria. Infected macrophages often undergo apoptotic cell death to efficiently present bacterial antigens to the host adaptive immune system
JNK-signaling: a multiplexing hub in programmed cell death
Dhanasekaran, Danny N and Reddy, E Premkumar
Genes & cancer, 8(9-10), 682-682 (2017)
Ulkan Kilic et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(2), 249-251 (2004-11-24)
Apart from its hematopoietic function, erythropoietin (Epo) exerts neuroprotective activity upon reduced oxygenation or ischemia of brain, retina, and spinal cord. To examine whether Epo has an impact on the retrograde degeneration of retinal ganglion cells (RGCs) following optic nerve
Zhi-Hu Lin et al.
International journal of biological macromolecules, 241, 124648-124648 (2023-04-30)
Clinically, COVID-19 is often accompanied by a severe immune response (cytokine storm) which produces a large number of cytokines, such as TNF-α, IL-6 and IL-12, and consequently causes acute respiratory distress syndrome (ARDS). GMI is a type of fungal immunomodulatory
Alexey I Goncharov et al.
Biochemistry. Biokhimiia, 86(11), 1446-1460 (2021-12-16)
Progesterone and its synthetic analogues act on cells through different types of receptors, affecting proliferation and apoptosis. These compounds exert their effect through the nuclear receptors and the insufficiently studied membrane progesterone receptors (mPRs) belonging to the progestin and adiponectin
Cosimo Stambe et al.
Kidney international, 64(6), 2121-2132 (2003-11-25)
The p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) are intracellular signal transduction pathways involved in the production of inflammatory mediators. Little, however, is known about the contribution of these pathways to renal inflammation, nor the cell types
M W Lopes et al.
Translational psychiatry, 6(12), e986-e986 (2016-12-14)
Glucocorticoids (GC) released during stress response exert feedforward effects in the whole brain, but particularly in the limbic circuits that modulates cognition, emotion and behavior. GC are the most commonly prescribed anti-inflammatory and immunosuppressant medication worldwide and pharmacological GC treatment
Pigment Epithelium-Derived Factor Alleviates Tamoxifen-Induced Endometrial Hyperplasia
Goldberg K, et al.
Molecular Cancer Therapeutics, 14(12), 2840-2849 (2015)
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