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María Antiñolo et al.
Nature communications, 6, 6812-6812 (2015-04-16)
Although it is known that soot particles are emitted in large quantities to the atmosphere, our understanding of their environmental effects is limited by our knowledge of how their composition is subsequently altered through atmospheric processing. Here we present an
Vijay Pawar et al.
Drug delivery, 22(3), 359-366 (2014-03-29)
The aim of this work was to prepare salts of 6-methoxy-2-naphthylacetic acid (6-MNA) to improve its physicochemical properties for percutaneous application. 6-MNA, an active metabolite of non-steroidal anti-inflammatory drug nabumetone has long half life and has the tendency to penetrate
Nargis Jamila et al.
Journal of enzyme inhibition and medicinal chemistry, 30(1), 133-139 (2014-03-29)
Context: Garcinia hombroniana Pierre, known as manggis hutan in Malaysia is a rich source of xanthones and benzophenones. This study was aimed to isolate and characterize potential cholinesterase inhibitors from the extracts of G. hombroniana bark and investigate their interactions
Diego E Kassuha et al.
Pharmaceutical development and technology, 20(4), 401-409 (2014-01-15)
The polymorphism of new and old active pharmaceutical ingredients (APIs) is of great importance due to performance, stability and processability aspects. The objective of this study was to investigate the polymorphism of deflazacort (DEF), a glucocorticoid discovered >40 years ago
Ting Guo et al.
Biosensors & bioelectronics, 74, 498-503 (2015-07-16)
A novel method combined the high selectivity of molecular imprinting technology with the strong fluorescence property of upconversion nanoparticles (UCNPs) for sensing of Cytochrome c (Cyt c) was proposed. The molecularly imprinted material-coated upconversion nanoparticles (UCNPs@MIP) were obtained by in
Abuzer Ali et al.
Natural product research, 29(14), 1307-1314 (2015-02-13)
The fruits of Withania coagulans Dunal (family: Solanaceae) are sweet, sedative, emetic, alterative and diuretic; used to treat asthma, biliousness, strangury, wounds, dyspepsia, flatulent colic, liver complaints and intestinal infections in the indigenous system of medicine. Phytochemical investigation of the
Jumah Masoud M Salmani et al.
Pharmaceutical development and technology, 20(4), 465-472 (2014-02-05)
Serious efforts have been made to overcome the bioavailability problems of ever increasing number of poorly soluble drugs, including atorvastatin (ATO); however, enhancing its gastric solubility has not received much attention. To improve the bioavailability of ATO by increasing its
Sha Li et al.
ACS applied materials & interfaces, 7(34), 19153-19162 (2015-08-14)
Because of their unique advantages, fluorescent carbon dots are gaining popularity in various biomedical applications. For these applications, good biosafety is a prerequisite for their use in vivo. Studies have reported the preliminary biocompatibility evaluations of fluorescent carbon dots (mainly
Nguyen-Thach Tung et al.
Archives of pharmacal research, 38(11), 1999-2007 (2015-05-06)
The potential of hydrogel containing nanostructured lipid carriers (NLC) to enhance the skin permeation rate and skin deposition of dexamethasone acetate (DEA) was investigated. The particle size of obtained NLCs was around 224.4 nm. NLCs had core-shell structure and DEA existed
Yan Han et al.
Chemical & pharmaceutical bulletin, 63(11), 882-889 (2015-11-03)
Novel tranylcypromine/hydroxylcinnamic acid hybrids 15a, b, and 19a-l were designed and synthesized by connecting tranylcypromine with hydroxylcinnamic acid, and their biological activities were evaluated. The in vitro assay of their inhibitory activities against lysine-specific demethylase 1 (LSD1) showed that most
João Bosco P da Silva et al.
European journal of medicinal chemistry, 100, 162-175 (2015-06-19)
A set of aryl- and phenoxymethyl-(thio)semicarbazones were synthetized, characterized and biologically evaluated against the larvae of Aedes aegypti (A. aegypti), the vector responsible for diseases like Dengue and Yellow Fever. (Q)SAR studies were useful for predicting the activities of the compounds
Benyi Xiao et al.
Bioresource technology, 196, 109-115 (2015-08-02)
This study investigated the damages of microbial cell structures, as well as the relationships between these damages and the release of cellular organic matter in the pretreatment of waste activated sludge (WAS) by using alkaline pretreatment as model. In the
Yifen Wen et al.
Colloids and surfaces. B, Biointerfaces, 133, 246-253 (2015-06-30)
Polysaccharide-based crosslinked nanogles (bionanogels) exhibiting multiple stimuli-responsive release of encapsulated therapeutics hold a great potential as tumor-targeting intracelluar durg delivery nanocarriers. Herein, we report the synthesis of monodisperse dual temperature/acidic pH-responsive bionanogels (DuR-BNGs) by aqueous crosslinking polymerization through temperature-induced self-association
Hariom Gupta et al.
Journal of colloid and interface science, 430, 221-228 (2014-06-24)
Water dispersible and biologically important molecule dehydroascorbic acid (DHA, capable to cross the blood brain barrier) coated Fe3O4 superparamagnetic nanoparticles having an average size of ∼6 nm were synthesized through one pot aqueous coprecipitation method under atmospheric air. An antioxidant
Johny Nicolas et al.
Environmental science. Processes & impacts, 17(11), 1952-1958 (2015-09-26)
The wide application and production of nanotechnology have increased the interest in studying the toxicity of nano- and micro-sized particles escaping into air from various aspects of the production process. Metal oxides (MOs) are one particular class of particles that
Ramakrishna V S Nirogi et al.
Journal of enzyme inhibition and medicinal chemistry, 30(1), 85-97 (2014-03-29)
A series of N'-[3-(indole-1-sulfonyl) aryl]-N,N-dimethyl ethane-1,2-diamines and N'-[3-(indole-1-sulfonyl) aryl]-N,N-dimethyl propane-1,3-diamines was designed and synthesized as 5-HT6 receptor ligands. These compounds, when screened in a functional reporter gene-based assay, displayed potent antagonistic activity with Kb values in the range of 1.8-60 nM.
Youjing Lv et al.
Marine drugs, 13(6), 3710-3731 (2015-06-26)
An apigalacturonan (AGA)-rich polysaccharide, ZCMP, was isolated from the sea grass Zostera caespitosa Miki. The depolymerized fragments derived from ZCMP were obtained by either acidic degradation or pectinase degradation, and their structures were characterized by electrospray ionization collision-induced-dissociation mass spectrometry
Fouzi Mouffouk et al.
International journal of nanomedicine, 10, 63-76 (2015-01-08)
Early cancer detection is a major factor in the reduction of mortality and cancer management cost. Here we developed a smart and targeted micelle-based contrast agent for magnetic resonance imaging (MRI), able to turn on its imaging capability in the
Gökhan Ceyhan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 149, 731-743 (2015-05-20)
Two imine compounds, 4-[(E)-(2-methoxybenzylidene)amino]phenol (L(1)) and 4-[(E)-(3,4-dimethoxybenzylidene)amino]phenol (L(2)) were synthesized and characterized by the analytical and spectroscopic methods. The electrochemical and photoluminescence properties of the imine compounds L(1) and L(2) were investigated in different solvents. The compounds L(1) and L(2)
Donna V Peralta et al.
Journal of microencapsulation, 31(8), 824-831 (2014-08-05)
Progress has been made in using human serum albumin nanoparticles (HSAPs) as promising colloidal carrier systems for early detection and targeted treatment of cancer and other diseases. Despite this success, there is a current lack of multi-functional HSAP hybrids that
Zhiwei Lu et al.
Materials science & engineering. C, Materials for biological applications, 52, 251-258 (2015-05-09)
The effect of the surface topography on protein adsorption process is of great significance for designing hydroxyapatite (HA) ceramic material surfaces. In this work, three different topographies of HA materials HA-sheet, HA-rod, and HA-whisker were synthesized and testified by X-ray
Yangmei Zhang et al.
Natural product research, 29(13), 1207-1211 (2015-01-03)
Phytochemical investigation of the roots of Gypsophila oldhamiana afforded two new β-carboline alkaloids, oldhamiaines A and B (1 and 2), along with a known analogue (3). Their structures were elucidated by using spectroscopic and chemical methods. This is the first
Sophie Rodrigues et al.
Probiotics and antimicrobial proteins, 7(1), 45-51 (2014-10-22)
Vibrio tapetis CECT4600 is a pathogenic Gram-negative bacterium causing the brown ring disease in the Manila clam Ruditapes philippinarum. This vibriosis is induced by bacterial attachment on the periostracal lamina, yielding a decalcification of the bivalve shell. As in many
Juan-Fernando Padín et al.
American journal of physiology. Cell physiology, 305(2), C160-C172 (2013-04-19)
The activity of the plasmalemmal Na(+)/Ca(2+) exchanger (NCX) is highly sensitive to temperature. We took advantage of this fact to explore here the effects of the NCX blocker KB-R7943 (KBR) at 22 and 37°C on the kinetics of Ca(2+) currents
Botao Qu et al.
Nanoscale research letters, 10, 42-42 (2015-04-09)
Porous metallic copper was successfully prepared by a simple thermal decomposition strategy. A coordination compound of Cu(BTA)2 with the morphology of micro-rod crystal was synthesized as the precursor. The precursor to copper transformation was performed and annealed at 600°C with
Chunfang Ma et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 72(3), 451-462 (2015-07-24)
The activated carbons (ACs) were prepared from glycyrrhiza residue by KOH or H₃PO₄activation and were used for removing Pb²⁺, Cd²⁺ and Ni²⁺ from simulated wastewater. The changes of the physical structure and chemical properties of the glycyrrhiza residue before and
Jun Zhou et al.
Journal of ethnopharmacology, 164, 229-238 (2015-02-24)
Rehmannia glutinosa (Gaertn.) DC. (RG) has been widely used as traditional Chinese herbal medicine for treatment of diabetes and its complications. The polysaccharide fraction of RG has been proposed to possess hypoglycemic effect by intraperitoneal administration, however, the mechanisms responsible
Zhanmin Liu et al.
Carbohydrate polymers, 134, 627-634 (2015-10-03)
Figures of persimmons for the world's top ten persimmon producing countries are about 4000,000 tons in 2011 and are increasing every year according to FAO statistics. However, there is not any report on pectin production by microbial with persimmon peel
PLGA-Mesoporous Silicon Microspheres for the in Vivo Controlled Temporospatial Delivery of Proteins.
Silvia Minardi et al.
ACS applied materials & interfaces, 7(30), 16364-16373 (2015-06-26)
In regenerative medicine, the temporospatially controlled delivery of growth factors (GFs) is crucial to trigger the desired healing mechanisms in the target tissues. The uncontrolled release of GFs has been demonstrated to cause severe side effects in the surrounding tissues.
Ke Zhang et al.
Nanoscale, 7(29), 12445-12451 (2015-07-03)
Due to the specific physical and chemical properties of a highly branched noble metal, the controllable synthesis has attracted much attention. This article reports the synthesis of Pd/Ru nanodendrites by a facile method using an oil bath in the presence
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