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Cédric Montigny et al.
The Journal of biological chemistry, 289(49), 33850-33861 (2014-10-11)
Sarcolipin (SLN) is a regulatory peptide present in sarcoplasmic reticulum (SR) from skeletal muscle of animals. We find that native rabbit SLN is modified by a fatty acid anchor on Cys-9 with a palmitic acid in about 60% and, surprisingly
Yoshiyuki Okano et al.
Molecular genetics and metabolism, 110(4), 424-430 (2013-10-08)
High serum phenylalanine in adult patients with phenylketonuria (PKU) causes neuropsychological and psychosocial problems that can be resolved by phenylalanine-restricted diet. Therefore, PKU patients must continue to adhere to phenylalanine-restricted diet for life, although the optimal serum phenylalanine level in
Recombinant phenylalanine ammonia lyase in phenylketonuria.
Francjan J van Spronsen et al.
Lancet (London, England), 384(9937), 6-8 (2014-04-20)
Tianwen Zhu et al.
Gene, 529(1), 80-87 (2013-08-13)
The value of genotyping to predict variant phenotypes in patients with phenylalanine hydroxylase (Pah) deficiency is a matter of debate. However, there exists no comprehensive population relationship study focused on the Han Chinese. We analyzed genotype-phenotype correlation for 186 different
Anthony Bertucci et al.
Bioorganic & medicinal chemistry, 18(6), 2300-2303 (2010-02-24)
The activity of the coral Stylophora pystillata secretory carbonic anhydrase STPCA has been tested in presence of amino acids and amines. All the investigated compounds showed a positive, activating effect on k(cat) and have been separated in weak (K(A) in
A C Cutró et al.
The journal of physical chemistry. B, 119(31), 10060-10065 (2015-07-29)
We study the binding of phenylalanine (Phe) with dipalmitoylphosphocholine (DPPC) vesicles in gel (25 °C) and in liquid crystalline states (50 °C) and in gel large unilamellar vesicles (LUVs) subjected to osmotic dehydration with merocyanine (MC 540) as a fluorescent
K J Bär et al.
Neurobiology of aging, 24(2), 333-338 (2002-12-25)
Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of
Is there a standard meal plan for phenylketonuria (PKU)?
Wendy Marcason
Journal of the Academy of Nutrition and Dietetics, 113(8), 1124-1124 (2013-07-28)
CTI Reviews
Clinical Chemistry, Principles, Procedures, Correlations (2016)
Protein and Amino Acid Metabolism
ESSENTIALS OF MEDICINAL CHEMISTRY null
J Zhang et al.
European review for medical and pharmacological sciences, 17(17), 2372-2382 (2013-09-26)
We previously showed that the calcium-binding protein S100A4 is overexpressed and related to metastasis in hepatocellular carcinoma (HCC). However, whether S100A4 participates in the regulation of metastasis and its mechanisms in HCC is mostly unknown. Given the associations of S100A4
Cem Albayrak et al.
Nucleic acids research, 41(11), 5949-5963 (2013-04-17)
We describe a new cell-free protein synthesis (CFPS) method for site-specific incorporation of non-natural amino acids (nnAAs) into proteins in which the orthogonal tRNA (o-tRNA) and the modified protein (i.e. the protein containing the nnAA) are produced simultaneously. Using this
Hunter Cuchiaro et al.
Journal of agricultural and food chemistry, 67(19), 5672-5679 (2019-04-25)
The analysis of protein in algal biomass is one of the most critical areas of commercial development of algae characterization for nutritional or other high value applications. A new rapid and accurate method is required that can be widely implemented
Yasuo Ido et al.
PloS one, 10(2), e0115341-e0115341 (2015-02-04)
The aging process is perceived as resulting from a combination of intrinsic factors such as changes in intracellular signaling and extrinsic factors, most notably environmental stressors. In skin, the relationship between intrinsic changes and keratinocyte function is not clearly understood.
Beatrice Bocca et al.
Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <
Mark G Jones et al.
Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)
Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is
Peptide deactivation: Spectroscopy meets theory.
Wolfgang Domcke et al.
Nature chemistry, 5(4), 257-258 (2013-03-21)
Oliver C Witard et al.
The American journal of clinical nutrition, 99(1), 86-95 (2013-11-22)
The intake of whey, compared with casein and soy protein intakes, stimulates a greater acute response of muscle protein synthesis (MPS) to protein ingestion in rested and exercised muscle. We characterized the dose-response relation of postabsorptive rates of myofibrillar MPS
Rico Schwarz et al.
Journal of medicinal chemistry, 56(11), 4252-4263 (2013-05-04)
Chemical cross-linking combined with an enzymatic digestion and mass spectrometric analysis of the reaction products has evolved into an alternative strategy to structurally resolve protein complexes. We investigated conformational changes in peroxisome proliferator-activated receptor α (PPARα) upon ligand binding. Using
Marcin Horbowicz et al.
Acta biochimica Polonica, 62(2), 235-240 (2015-04-10)
Methyl jasmonate has a strong effect on secondary metabolizm in plants, by stimulating the biosynthesis a number of phenolic compounds and alkaloids. Common buckwheat (Fagopyrum esculentum Moench) is an important source of biologically active compounds. This research focuses on the
T Nikopensius et al.
Journal of dental research, 92(10), 893-898 (2013-08-24)
Class III malocclusion is a common dentofacial phenotype with a variable prevalence according to ethnic background. The etiology of Class III malocclusion has been attributed mainly to interactions between susceptibility genes and environmental factors during the morphogenesis of the mandible
János Bókay et al.
Orvosi hetilap, 154(18), 683-687 (2013-05-01)
Elevated maternal phenylalanine levels during pregnancy are teratogenic, and may result in embryo-foetopathy, which could lead to stillbirth, significant psychomotor handicaps and birth defects. This foetal damage is known as maternal phenylketonuria. Women of childbearing age with all forms of
Georg A Sprenger
Applied microbiology and biotechnology, 75(4), 739-749 (2007-04-17)
Recombinant strains of Escherichia coli K-12 for the production of the three aromatic amino acids (L-phenylalanine, L-tryptophan, L-tyrosine) have been constructed. The largest demand is for L-phenylalanine (L-Phe), as it can be used as a building block for the low-calorie
Kevin Guo et al.
Analytical chemistry, 81(10), 3919-3932 (2009-03-25)
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be
G Neurauter et al.
Current drug metabolism, 9(7), 622-627 (2008-09-11)
Neuropsychiatric symptoms like mood changes and depression are common in patients with chronic inflammatory disorders such as infections, autoimmune diseases or cancer. The pathogenesis of these symptoms is still unclear. Pro-inflammatory stimuli interfere not only with the neural circuits and
Paul J Kennedy et al.
Psychopharmacology, 232(8), 1357-1371 (2014-10-24)
A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine
Penelope J Cross et al.
FEBS letters, 587(18), 3063-3068 (2013-08-07)
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS) catalyses the first step of the shikimate pathway for the biosynthesis of aromatic amino acids. Allosteric regulation of Thermotoga maritima DAH7PS is mediated by L-Tyr binding to a discrete ACT regulatory domain appended to a core
Maureen Cleary et al.
Molecular genetics and metabolism, 110(4), 418-423 (2013-10-05)
Fluctuations in blood phenylalanine concentrations may be an important determinant of intellectual outcome in patients with early and continuously treated phenylketonuria (PKU). This review evaluates the studies on phenylalanine fluctuations, factors affecting fluctuations, and if stabilizing phenylalanine concentrations affects outcomes
Bart Pennings et al.
The American journal of clinical nutrition, 98(1), 121-128 (2013-05-03)
Older individuals generally experience a reduced food-chewing efficiency. As a consequence, food texture may represent an important factor that modulates dietary protein digestion and absorption kinetics and the subsequent postprandial protein balance. We assessed the effect of meat texture on
Mark R Charbonneau et al.
Communications biology, 4(1), 898-898 (2021-07-24)
The development of therapeutics depends on predictions of clinical activity from pre-clinical data. We have previously described SYNB1618, an engineered bacterial therapeutic (synthetic biotic) for the treatment of Phenylketonuria (PKU), a rare genetic disease that leads to accumulation of plasma
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