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Enzymes in the D-alanine branch of bacterial cell wall peptidoglycan assembly.
C T Walsh
The Journal of biological chemistry, 264(5), 2393-2396 (1989-02-15)
C J L Silwood et al.
Journal of dental research, 81(6), 422-427 (2002-07-05)
We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and
Zhen Yan et al.
Biochimica et biophysica acta, 1844(4), 736-743 (2014-02-05)
Heterodimeric 2-oxoacid:ferredoxin oxidoreductase (OFOR) from Sulfolobus tokodaii (StOFOR) has only one [4Fe-4S]²⁺ cluster, ligated by 4 Cys residues, C12, C15, C46, and C197. The enzyme has no other Cys. To elucidate the role of these Cys residues in holding of
Dale A Schoeller
The Journal of nutrition, 143(6), 763-765 (2013-04-26)
Light element isotope signatures have been used to study food webs in many ecological niches, including those of ancient humans, but to a far lesser extent in modern humans. A recent paper presented results from a pilot study testing the
Industrial production of L-alanine using immobilized Escherichia coli and Pseudomonas dacunhae.
I Chibata et al.
Microbiological sciences, 1(3), 58-62 (1984-06-01)
Mark G Jones et al.
Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)
Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is
Aubérie Parent et al.
Nature communications, 6, 5686-5686 (2015-01-20)
Friedreich's ataxia is a severe neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein that stimulates iron-sulfur (Fe-S) cluster biogenesis. In mammals, the primary steps of Fe-S cluster assembly are performed by the NFS1-ISD11-ISCU complex via the
Riccardo Montioli et al.
Human molecular genetics, 23(22), 5998-6007 (2014-07-06)
Primary Hyperoxaluria type I (PH1) is a rare disease due to the deficit of peroxisomal alanine:glyoxylate aminotransferase (AGT), a homodimeric pyridoxal-5'-phosphate (PLP) enzyme present in humans as major (Ma) and minor (Mi) allele. PH1-causing mutations are mostly missense identified in
Seok-Min Kang et al.
Clinical biochemistry, 44(4), 293-299 (2010-12-21)
We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics. Patients with systolic HF of ischemic origin (n=15) and healthy controls (n=20) participated in this study. Patients with
Anthony El-Khoueiry et al.
Cancer chemotherapy and pharmacology, 72(1), 53-64 (2013-05-31)
Hepatic impairment may impede tyrosine kinase inhibitor metabolism. This phase I study compared the pharmacokinetics of brivanib in patients with hepatocellular carcinoma (HCC) and varying levels of hepatic impairment with those with non-HCC malignancies and normal liver function. Patients were
Y Subhash et al.
International journal of systematic and evolutionary microbiology, 64(Pt 5), 1580-1586 (2014-01-31)
Two bacterial strains (JC167T and JC168) were isolated from a soil sample collected from Mandpam, Tamilnadu, India. Colonies of both strains were orange and cells Gram-stain-positive. Cells were small rods, and formed terminal endospores of ellipsoidal to oval shape. Both
Rebamipide suppresses collagen-induced arthritis through reciprocal regulation of th17/treg cell differentiation and heme oxygenase 1 induction.
Moon SJ, Park JS, Woo YJ, et al.
Arthritis & Rheumatology (Hoboken, N.J.), 66(4), 874-885 (2014)
Karolina Malecek et al.
Journal of immunological methods, 392(1-2), 1-11 (2013-03-19)
T cell receptors (TCRs) on T cells recognize peptide-major histocompatibility complex (pMHC) molecules on the surface of antigen presenting cells and this interaction determines the T cell immune response. Due to negative selection, naturally occurring TCRs bind self (tumor) peptides
Reno Winter et al.
Biological chemistry, 394(8), 951-963 (2013-04-25)
The prospective increase in life expectancy will be accompanied by a rise in the number of elderly people who suffer from ill health caused by old age. Many diseases caused by aging are protein misfolding diseases. The molecular mechanisms underlying
P Klassen et al.
The American journal of clinical nutrition, 73(3), 647-652 (2001-03-10)
Plasma free amino acid patterns in health and disease have been reported. However, amino acid concentrations in adult populations in developing countries and in patients with dengue, as a model for an acute infectious viral disease endemic to the tropics
Antonio Rodríguez-Núñez et al.
Brain & development, 25(2), 102-106 (2003-02-13)
To determine the effects of meningitis on cerebral energy metabolism, cerebrospinal fluid concentrations of adenosine monophosphate, inosine monophosphate, inosine, adenosine, guanosine, adenine, guanine, hypoxanthine, xanthine and urate were determined by high-performance liquid chromatography, and neuron-specific enolase by an enzyme immunoassay
Damineh Morsali et al.
Brain : a journal of neurology, 136(Pt 4), 1067-1082 (2013-03-23)
Axonal degeneration is a major cause of permanent disability in the inflammatory demyelinating disease multiple sclerosis, but no therapies are known to be effective in axonal protection. Sodium channel blocking agents can provide effective protection of axons in the white
Sami Hraiech et al.
PloS one, 9(10), e107125-e107125 (2014-10-29)
The effectiveness of antibiotic molecules in treating Pseudomonas aeruginosa pneumonia is reduced as a result of the dissemination of bacterial resistance. The existence of bacterial communication systems, such as quorum sensing, has provided new opportunities of treatment. Lactonases efficiently quench
Alanine scanning mutagenesis of the human erythrocyte glucose transporter putative ATP binding domain.
K B Levine et al.
Blood cells, molecules & diseases, 27(1), 139-142 (2001-05-19)
Aaron D Pearson et al.
Science (New York, N.Y.), 347(6224), 863-867 (2015-02-24)
The fleeting lifetimes of the transition states (TSs) of chemical reactions make determination of their three-dimensional structures by diffraction methods a challenge. Here, we used packing interactions within the core of a protein to stabilize the planar TS conformation for
Di Wu et al.
Biochemical and biophysical research communications, 433(4), 538-541 (2013-03-26)
The Hippo (Hpo) pathway is a conserved tumor suppressor pathway that controls organ size through the coordinated regulation of apoptosis and proliferation. Drosophila Salvador (Sav), which limits organ size, is a core component of the Hpo pathway. In this study
Yoon Jeong Choi et al.
Digestive diseases and sciences, 59(12), 2927-2934 (2014-10-07)
PMK-S005 is synthetic s-allyl-L-cysteine (SAC), a sulfur-containing amino acid, which was initially isolated from garlic. The antioxidant and anti-inflammation activities of SAC have been demonstrated in diverse experimental animal models. The purpose of this study was to investigate the gastroprotective
Su Young Noh et al.
Molecular immunology, 64(1), 183-189 (2014-12-08)
Lactobacilli are probiotic bacteria that are considered to be beneficial in the gastrointestinal tract of humans. Although lactobacilli are well known to alleviate intestinal inflammation, the molecular basis of this phenomenon is poorly understood. In this study, we investigated the
Semagacestat's fall: where next for AD therapies?
Kaj Blennow et al.
Nature medicine, 19(10), 1214-1215 (2013-10-09)
Paul J Kennedy et al.
Psychopharmacology, 232(8), 1357-1371 (2014-10-24)
A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine
Kevin Guo et al.
Analytical chemistry, 81(10), 3919-3932 (2009-03-25)
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be
J Saklatvala
The Journal of clinical investigation, 59(5), 794-801 (1977-05-01)
A new type of enzyme hydrolyzing the elastase substrate succinyl-L-alanyl-L-alanine-4-nitroanilide has been found in cell-free rheuma todi synovial fluid. Normal plasma and osteoarthritic synovial fluid contained relatively little enzyme. The pH optimum was 8.0. Unexpectedly, the enzyme activity was not
William A Dew et al.
Chemosphere, 112, 519-525 (2014-03-19)
The olfactory system of fish comprises several classes of olfactory sensory neurons (OSNs). The odourants L-alanine and taurocholic acid (TCA) specifically activate microvillous or ciliated OSNs, respectively, in fish. We recorded electro-olfactograms (EOG) in fathead minnows (Pimephales promelas; a laboratory-reared
Jolie Ringash et al.
Cancer, 120(2), 181-189 (2013-10-16)
The CO.20 trial randomized patients with K-RAS wild-type, chemotherapy-refractory, metastatic colorectal cancer to receive cetuximab (CET) plus brivanib alaninate (BRIV) or CET plus placebo (CET/placebo). Quality of life (QoL) was assessed using the European Organization for Research and Treatment of
Kesavan Devarayan et al.
Carbohydrate polymers, 94(1), 468-478 (2013-04-03)
N(α)-t-Butyloxycarbonyl (Boc)-amino acids (Xaa = Gly, Ala, or β-Ala) were reacted with the cellulose hydroxyl groups (O-acylation) using N,N'-carbonyl diimidazole. The degrees of substitution toward the total hydroxyl groups (DS%(/OH)s) were 38% for O-(Boc-Gly)-Cellulose, 29% for O-(Boc-Ala)-Cellulose and 53% for
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