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Linda Mondini et al.
Molecular genetics and genomics : MGG, 290(2), 531-544 (2014-10-22)
To identify potential and useful markers able to discriminate promising lines of durum wheat (Triticum turgidum L. var durum) tolerant to salt and drought stresses, nucleotide sequences of Dehydration-Responsive-Element Binding Factor (DREB) genes were used to design primers probed with
Domenica Scumaci et al.
PloS one, 10(6), e0129762-e0129762 (2015-06-11)
Breast cancer (BC) is a leading cause of death among women. Among the major risk factors, an important role is played by familial history of BC. Germ-line mutations in BRCA1/2 genes account for most of the hereditary breast and/or ovarian
Paul M Klenowski et al.
Journal of neurophysiology, 114(2), 942-957 (2015-06-05)
The basolateral amygdala (BLA) is a complex brain region associated with processing emotional states, such as fear, anxiety, and stress. Some aspects of these emotional states are driven by the network activity of synaptic connections, derived from both local circuitry
Nabil A Rashdan et al.
American journal of physiology. Heart and circulatory physiology, 309(10), H1655-H1666 (2015-09-27)
Placental growth factor (PLGF), a potent stimulator of arteriogenesis, is upregulated during outward arterial remodeling. Increased fluid shear stress (FSS) is a key physiological stimulus for arteriogenesis. However, the role of FSS in regulating PLGF expression is unknown. To test
Maria Favia et al.
American journal of physiology. Lung cellular and molecular physiology, 307(1), L48-L61 (2014-05-13)
Cystic fibrosis transmembrane conductance regulator (CFTR) carrying the F508del mutation is retained in endoplasmic reticulum and fails to traffic to the cell surface where it functions as a protein kinase A (PKA)-activated chloride channel. Pharmacological correctors that rescue the trafficking
Keita Fukushima et al.
Cancer science, 106(8), 1000-1007 (2015-05-29)
Patients with inflammatory bowel disease (IBD) have an increased risk of developing colitis-associated colorectal cancer (CAC). CAC cells often develop chemoresistance, resulting in a poorer prognosis than that of sporadic colorectal cancer (CRC). The mechanism by which CAC enhances malignant
Knut H Lauritzen et al.
American journal of physiology. Heart and circulatory physiology, 309(3), H434-H449 (2015-06-10)
Cardiac mitochondrial dysfunction has been implicated in heart failure of diverse etiologies. Generalized mitochondrial disease also leads to cardiomyopathy with various clinical manifestations. Impaired mitochondrial homeostasis may over time, such as in the aging heart, lead to cardiac dysfunction. Mitochondrial
David Schult et al.
Scientific reports, 5, 16965-16965 (2015-11-26)
Enhancer of zeste homolog 2 (EZH2) is a core epigenetic regulator, playing a crucial role in cell cycle regulation. The protein is known to be associated with proliferation and worse outcome in several tumor entities. In this study, we immunohistochemically
Yan Yan et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 329-338 (2015-05-23)
There is a lack of an HSV-2 vaccine, in part as the result of various factors that limit robust and long-term memory immune responses at the mucosal portals of viral entry. We previously demonstrated that chemokine CCL19 augmented mucosal and
Ningfeng Tang et al.
Alcoholism, clinical and experimental research, 38(11), 2722-2730 (2014-11-26)
Fetal alcohol spectrum disorder, the leading known cause of mental retardation, is caused by alcohol exposure during pregnancy. One mechanism of ethanol (EtOH) teratogenicity is the disruption of the functions of L1 cell adhesion molecule (L1). These functions include enhancement
Objective, comparative assessment of the penetration depth of temporal-focusing microscopy for imaging various organs.
Christopher J Rowlands et al.
Journal of biomedical optics, 20(6), 61107-61107 (2015-04-07)
Junjie Zhang et al.
PLoS pathogens, 11(6), e1005001-e1005001 (2015-06-25)
Human gamma herpesviruses, including Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), are capable of inducing tumors, particularly in in immune-compromised individuals. Due to the stringent host tropism, rodents are resistant to infection by human gamma herpesviruses, creating a significant
Jie Yang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 72, 125-134 (2015-06-10)
Oridonin, a bioactive diterpenoid isolated from Rabdosia rubescens, has been found to exhibit various anti-tumor effects. In this work, to investigate its pharmacological effects on human colorectal carcinoma HCT-116 and LoVo cells, cell proliferation and apoptosis were respectively evaluated by
B K A Seong et al.
Oncogene, 34(27), 3582-3592 (2014-09-16)
Osteosarcoma (OS) is the most common malignant bone tumor and the majority of recurrences are due to metastasis. However, the molecular mechanisms that regulate OS metastatic spread are largely unknown. In this study, we report that special AT-rich-binding protein 2
Martin Alexander Schick et al.
PloS one, 10(9), e0137247-e0137247 (2015-09-05)
Volume therapy is a standard procedure in daily perioperative care, and there is an ongoing discussion about the benefits of colloid resuscitation with hydroxyethylstarch (HES). In sepsis HES should be avoided due to a higher risk for acute kidney injury
Q-j Wang et al.
Placenta, 36(4), 350-356 (2015-02-07)
Preeclampsia (PE) is a pregnancy-specific complication and it is related to insufficient extravillous trophoblast invasion. To date, the pathophysiology of PE has not yet been fully elucidated. Response gene to complement 32 (RGC32) is a novel cellular protein, and it
Ronald P M Gonçalves et al.
Shock (Augusta, Ga.), 42(5), 415-423 (2014-07-09)
The aim of the present study was to investigate the existence of gender-related differences in the profile of changes that occur in cardiac functionality during endotoxic shock. For this, both male and female Wistar rats received a single injection of
Jianquan Chen et al.
PLoS genetics, 10(1), e1004145-e1004145 (2014-02-06)
WNT signaling has been implicated in both embryonic and postnatal bone formation. However, the pertinent WNT ligands and their downstream signaling mechanisms are not well understood. To investigate the osteogenic capacity of WNT7B and WNT5A, both normally expressed in the
Charlotte M Thomas et al.
Parasitology, 142(11), 1375-1386 (2015-07-15)
FhCaBP2 is a Fasciola hepatica protein which belongs to a family of helminth calcium-binding proteins which combine an N-terminal domain containing two EF-hand motifs and a C-terminal dynein light chain-like (DLC-like) domain. Its predicted structure showed two globular domains joined
Hanna Österman et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(10), R1204-R1214 (2015-10-02)
Fetal growth restriction programs an increased risk of cardiovascular disease in adulthood, but the actual mechanisms of this developmental programming are not fully understood. Previous studies in mammalian models suggest that hearts of growth-restricted fetuses have reduced cardiomyocyte number due
Ai-Hui Tang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(9), 3938-3945 (2015-03-06)
The Fmr1 knock-out mouse model of fragile X syndrome (Fmr1(-/y)) has an epileptogenic phenotype that is triggered by group I metabotropic glutamate receptor (mGluR) activation. We found that a membrane-permeable peptide that disrupts mGluR5 interactions with long-form Homers enhanced mGluR-induced
Chun-Chun Hsu et al.
Journal of applied physiology (Bethesda, Md. : 1985), 118(12), 1533-1543 (2015-04-11)
Both transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are abundantly expressed in bronchopulmonary C-fiber sensory nerves and can be activated by a number of endogenous inflammatory mediators. A recent study has reported a synergistic effect of
Marisa O King et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 185(3), 333-342 (2015-01-15)
Migrant birds require large flight muscles and hearts to enhance aerobic capacity and support sustained flight. A potential mechanism for increasing muscle and heart masses during migration in birds is the muscle growth inhibitor myostatin and its metalloproteinase activators, tolloid-like
Rand Arafeh et al.
Nature genetics, 47(12), 1408-1410 (2015-10-27)
Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in
Maritta Küspert et al.
RNA (New York, N.Y.), 21(7), 1294-1305 (2015-05-24)
mRNAs are key molecules in gene expression and subject to diverse regulatory events. Regulation is accomplished by distinct sets of trans-acting factors that interact with mRNAs and form defined mRNA-protein complexes (mRNPs). The resulting "mRNP code" determines the fate of
Yeonee Seol et al.
Molecular cancer therapeutics, 14(11), 2552-2559 (2015-09-10)
Human nuclear type IB topoisomerase (Top1) inhibitors are widely used and powerful anticancer agents. In this study, we introduce and validate a single-molecule supercoil relaxation assay as a molecular pharmacology tool for characterizing therapeutically relevant Top1 inhibitors. Using this assay
Ling-yun Li et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(41), 13670-13683 (2014-10-10)
Sensory information undergoes ordered and coordinated processing across cortical layers. Whereas cortical layer (L) 4 faithfully acquires thalamic information, the superficial layers appear well staged for more refined processing of L4-relayed signals to generate corticocortical outputs. However, the specific role
Yan He et al.
Journal of chromatography. A, 1408, 261-266 (2015-07-22)
This paper describes the use of an anionic ion-pair reagent (IPR) to impove the ultraviolet (UV) detection and hydrophobic retention of polar and UV transparent cations. Anionic IPR added to the mobile phase forms an ion-pair with cations. Formation of
Elena Berezhnaya et al.
Journal of biomedical optics, 20(7), 75004-75004 (2015-07-15)
Photodynamic therapy (PDT) is currently used in the treatment of brain tumors. However, not only malignant cells but also neighboring normal neurons and glial cells are damaged during PDT. In order to study the potential role of transcription factors-nuclear factor
Jason M Dwyer et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(19), 6188-6193 (2015-04-29)
Current treatments for major depressive disorder (MDD) have a time lag and are ineffective for a large number of patients. Development of novel pharmacological therapies requires a comprehensive understanding of the molecular events that contribute to MDD pathophysiology. Recent evidence
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