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Jin-Ah Lee et al.
Nutrients, 7(11), 9650-9661 (2015-11-28)
The aim of this study was to improve the anti-inflammatory activities of apigenin through co-treatment with resveratrol as a bioenhancer of apigenin. RAW 264.7 cells pretreated with hepatic metabolites formed by the co-metabolism of apigenin and resveratrol (ARMs) in HepG2
Sina R Gottstein-Schmidtke et al.
RNA (New York, N.Y.), 20(8), 1163-1172 (2014-06-22)
The U-turn is a classical three-dimensional RNA folding motif first identified in the anticodon and T-loops of tRNAs. It also occurs frequently as a building block in other functional RNA structures in many different sequence and structural contexts. U-turns induce
Yumin Wen et al.
BMC complementary and alternative medicine, 15, 155-155 (2015-05-28)
Yi Qi Qing Re Gao (YQQRG) formula is a traditional Chinese herbal medicine used to treat chronic nephritis. This study was designed to evaluate the underlying mechanism in the use of YQQRG formula to treat nephrosis induced by puromycin aminonucleoside
Xin-Zhuang Yang et al.
Molecular biology and evolution, 32(12), 3143-3157 (2015-09-06)
Although millions of RNA editing events have been reported to modify hereditary information across the primate transcriptome, evidence for their functional significance remains largely elusive, particularly for the vast majority of editing sites in noncoding regions. Here, we report a
Gábor Wittmann et al.
Endocrinology, 155(5), 2009-2019 (2014-03-08)
Thyroid hormone regulates immune functions and has antiinflammatory effects. In promoter assays, the thyroid hormone-activating enzyme, type 2 deiodinase (D2), is highly inducible by the inflammatory transcription factor nuclear factor-κ B (NF-κB), but it is unknown whether D2 is induced
T Trdan Lušin et al.
Die Pharmazie, 70(2), 94-96 (2015-05-23)
Bazedoxifene is used for the prevention and treatment of osteoporosis. After peroral application, bazedoxifene is metabolized by UDP-glucuronosyltransferases (UGTs) to bazedoxifene-4'-glucuronide (M4) and bazedoxifene-5-glucuronide (M5). It has already been shown that a relatively common UGT1A1*28 polymorphism can considerably affect raloxifene
Ana Sofia Soares et al.
Basic & clinical pharmacology & toxicology, 116(1), 25-36 (2014-06-10)
Malignant melanoma is the most deadly type of skin cancer. The lack of effective pharmacological approaches for this tumour can be related to the incomplete understanding of the pathophysiological mechanisms involved in melanoma cell proliferation. Adenosine has growth-promoting and growth
Szymon Bocian et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 990, 198-202 (2015-04-23)
Chromatographic properties of two columns was compared: commercial IAM.PC.DD2 that imitates the cell membrane and home-made Amino-P-C18 (N,O-dialkylphosphoramidate C18). The comparison has been done by correlation of retention (logkw parameters) of a series of solutes: hydrophobic (alkyl benzene derivatives and
Nourdine Hamdane et al.
PLoS genetics, 10(8), e1004505-e1004505 (2014-08-15)
Upstream Binding Factor (UBF) is a unique multi-HMGB-box protein first identified as a co-factor in RNA polymerase I (RPI/PolI) transcription. However, its poor DNA sequence selectivity and its ability to generate nucleosome-like nucleoprotein complexes suggest a more generalized role in
G P Connolly et al.
Trends in pharmacological sciences, 20(5), 218-225 (1999-06-04)
There are many disorders of pyrimidine metabolism and those that involve an alteration in uridine metabolism have neurological and systemic effects, which provide insights into the biological activity of uridine and its analogues. Studies of the metabolism and actions of
Cheng Ma et al.
PloS one, 10(11), e0143010-e0143010 (2015-11-26)
Membrane proteins play key roles in many biological processes, from acquisition of nutrients to neurotransmission, and are targets for more than 50% of current therapeutic drugs. However, their investigation is hampered by difficulties in their production and purification on a
Jermaine L Jenkins et al.
Nucleic acids research, 41(6), 3859-3873 (2013-02-05)
Degenerate splice site sequences mark the intron boundaries of pre-mRNA transcripts in multicellular eukaryotes. The essential pre-mRNA splicing factor U2AF(65) is faced with the paradoxical tasks of accurately targeting polypyrimidine (Py) tracts preceding 3' splice sites while adapting to both
Lingmin Yuan et al.
Biochemical pharmacology, 95(1), 58-70 (2015-03-17)
Most human UDP-glucuronosyltransferase (UGT; EC genes contain non-synonymous single nucleotide polymorphisms (nsSNPs) which cause amino acid substitutions. Allelic variants caused by nsSNPs may exhibit absent or reduced enzyme activity. UGT2B7 is one of the most important UGTs that glucuronidates
Zhen Liu et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 190, 46-53 (2015-09-06)
Stem-loop-binding proteins (SLBPs) have been revealed to interact with stem-loop of histones, and oocyte-specific and oocyte-preferential SLBP2 have been identified in vertebrates including Xenopus (S. tropicalis) and B. taurus to play a key role in histone translation regulation, but no
Johannes Zander et al.
Infection and immunity, 76(4), 1333-1339 (2007-12-28)
Thymidine-dependent small-colony variants (SCVs) of Staphylococcus aureus are frequently associated with persistent and recurrent infections in cystic fibrosis patients. The phenotypic appearance of S. aureus SCVs or normal-colony variants (NCVs) is postulated to be affected by the intracellular amount of
Racheal O Ogbodu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 149, 231-239 (2015-05-13)
The photophysical properties of the conjugate of uridine and zinc mono carboxy phenoxy phthalocyanine (ZnMCPPc-uridine, 4) are reported in this work. The conjugate was also adsorbed onto single walled carbon nanotubes (ZnMCPPc-uridine-SWCNT, 5). The X-ray photoelectron spectroscopy of 4 showed
Takuma Higurashi et al.
Carcinogenesis, 35(9), 2134-2141 (2014-06-25)
Leptin, secreted by the adipose tissue and known to be related to obesity, is considered to be involved in the onset and progression of colorectal cancer. However, the exact role of leptin in colorectal carcinogenesis is still unclear, as several
Vicente Ramírez et al.
PLoS genetics, 11(10), e1005586-e1005586 (2015-10-23)
tRNA is the most highly modified class of RNA species, and modifications are found in tRNAs from all organisms that have been examined. Despite their vastly different chemical structures and their presence in different tRNAs, occurring in different locations in
Chunjing Feng et al.
Talanta, 143, 101-106 (2015-06-17)
Here, we developed an enzyme-free, label-free, and sensitive fluorescence cooperative amplification strategy based on a hairpin assembly circuit which coupled catalytic hairpin assembly (CHA) with hybridization chain reaction (HCR) for small molecule adenosine. A double-strand DNA probe with aptamer-catalysis strand
Ellen J B Derissen et al.
Journal of pharmaceutical and biomedical analysis, 110, 58-66 (2015-03-26)
5-Fluorouracil (5-FU) and its oral prodrug capecitabine are among the most widely used chemotherapeutics. For cytotoxic activity, 5-FU requires cellular uptake and intracellular metabolic activation. Three intracellular formed metabolites are responsible for the antineoplastic effect of 5-FU: 5-fluorouridine 5'-triphosphate (FUTP)
Fay Probert et al.
Journal of pharmaceutical and biomedical analysis, 117, 276-288 (2015-09-24)
Niemann-Pick type C1 (NP-C1) disease is a neurodegenerative lysosomal storage disease for which the only approved therapy is miglustat (MGS). In this study we explored the applications and value of both one- and two-dimensional high-resolution NMR analysis strategies to the
Majida Charif et al.
American journal of medical genetics. Part A, 167A(10), 2366-2374 (2015-06-11)
We report on clinical, genetic and metabolic investigations in a family with optic neuropathy, non-progressive cardiomyopathy and cognitive disability. Ophthalmic investigations (slit lamp examination, funduscopy, OCT scan of the optic nerve, ERG and VEP) disclosed mild or no decreased visual
Izabella Z A Pawluczyk et al.
Laboratory investigation; a journal of technical methods and pathology, 95(9), 1019-1028 (2015-06-30)
Defects in sialylation are known to have serious consequences on podocyte function leading to collapse of the glomerular filtration barrier and the development of proteinuria. However, the cellular processes underlying aberrant sialylation in renal disease are inadequately defined. We have
D Essaid et al.
Journal of pharmaceutical and biomedical analysis, 114, 227-240 (2015-06-24)
Porphyrins are a class of photosensitizers used in photodynamic therapy (PDT). Understanding the interaction of porphyrins with membrane cells components is important in order to improve this therapy. Many analytical methods can be used for this aim. High performance liquid
Mehmet Cansev
Brain research reviews, 52(2), 389-397 (2006-06-14)
The pyrimidines cytidine (as CTP) and uridine (which is converted to UTP and then CTP) contribute to brain phosphatidylcholine and phosphatidylethanolamine synthesis via the Kennedy pathway. Their uptake into brain from the circulation is initiated by nucleoside transporters located at
Lucía Ibares-Frías et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 253(7), 1071-1083 (2015-03-07)
To evaluate corneal wound healing in the hen animal model after additive surgery with an intracorneal ring segment (ICRS). We implanted one ICRS in each eye of 76 hens. In control group 1 (n = 22 hens), the stromal channel was prepared
Dan Liu et al.
Journal of chromatography. A, 1356, 157-162 (2014-07-08)
Hydrophilic organic/salt-containing aqueous two-phase system composing of ethanol, water and ammonium sulfate for separation polar compounds was investigated on multilayer coil associated with J-type HSCCC devices. Compared to the classical polar solvent system based on 1-butanol-water or PEG1000-ammonium sulfate-water, the
Roman Komor et al.
Acta poloniae pharmaceutica, 69(6), 1259-1269 (2013-01-05)
The synthesis of (5-nitro-2-pyridyl) 2-deoxy-1-thioglycosides is presented. Obtained compounds were used in the synthesis of uridine derivatives, potential glycosyltransferases inhibitors. In the first stage of the research 2-deoxyglucose and 2-deoxygalactose were connected to aglycone (nitropyridine derivative) via alpha-1-thioglycosidic bond. Therefore
Salvador Meseguer et al.
Human molecular genetics, 24(1), 167-184 (2014-08-26)
Mitochondrial dysfunction activates mitochondria-to-nucleus signaling pathways whose components are mostly unknown. Identification of these components is important to understand the molecular mechanisms underlying mitochondrial diseases and to discover putative therapeutic targets. MELAS syndrome is a rare neurodegenerative disease caused by
Wei Wang et al.
Molecular cell, 56(5), 708-716 (2014-12-03)
PIWI-interacting RNAs (piRNAs) silence transposons in animal germ cells. PIWI proteins bind and amplify piRNAs via the "Ping-Pong" pathway. Because PIWI proteins cleave RNAs between target nucleotides t10 and t11-the nucleotides paired to piRNA guide positions g10 and g11-the first
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