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S A Wudy et al.
Steroids, 66(10), 759-762 (2001-08-28)
A first assay based on stable isotope dilution/gas chromatography-mass spectrometry has been developed for plasma 17alpha-hydroxypregnenolone, the leading marker of 3beta-hydroxysteroid dehydrogenase deficiency. Equilibration of plasma with internal standard was followed by solid phase extraction. After clean up using Sephadex
Vessela Vitcheva et al.
Oxidative medicine and cellular longevity, 2015, 157876-157876 (2015-11-18)
One of the mechanisms involved in the development of addiction, as well as in brain toxicity, is the oxidative stress. The aim of the current study was to investigate the effects of 7-nitroindazole (7-NI), a selective inhibitor of neuronal nitric
Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia.
Sascha Dietrich et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e300-e303 (2013-05-22)
Song Yi et al.
Nature protocols, 12(11), 2323-2341 (2017-10-06)
A complete understanding of human cancer variants requires new methods to systematically and efficiently assess the functional effects of genomic mutations at a large scale. Here, we describe a set of tools to rapidly clone and stratify thousands of cancer
Inge Derad et al.
Hypertension (Dallas, Tex. : 1979), 63(4), 762-767 (2014-01-15)
Intranasal administration of angiotensin II (ANGII) affects blood pressure in a mode different from intravenously administered ANGII via a direct access to the brain bypassing the blood-brain barrier. This clinical study investigated blood pressure regulation after intranasal ANGII administration in
Concerns for the heart failure reduction in the NAGOYA HEART Study based on meta-regression from the evidence.
Hisato Takagi et al.
Hypertension (Dallas, Tex. : 1979), 62(5), e31-e32 (2013-09-11)
Christoph B Messner et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(28), 7403-7407 (2017-06-28)
The evolutionary origins of metabolism, in particular the emergence of the sugar phosphates that constitute glycolysis, the pentose phosphate pathway, and the RNA and DNA backbone, are largely unknown. In cells, a major source of glucose and the large sugar
D Rating et al.
Journal of neurology, 230(4), 217-225 (1983-01-01)
In 14 children with epilepsy, 51 with febrile convulsions and 22 with meningitis gamma-aminobutyric acid (GABA) concentrations in lumbar CSF were determined. While the mean for CSF GABA concentrations for all epileptic children was unchanged [144 (range: 73-285) pmol/ml; controls:
C J L Silwood et al.
Journal of dental research, 81(6), 422-427 (2002-07-05)
We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and
Tatsuo K Sato et al.
Nature neuroscience, 17(1), 30-32 (2013-11-19)
Neurons in different locations across the cortex are connected through polysynaptic networks involving both excitation and inhibition. To probe the functional effect of such networks, we used optogenetic stimulation to trigger antidromic spikes in a local region of primary visual
Junbo Li et al.
Luminescence : the journal of biological and chemical luminescence, 30(5), 643-648 (2014-10-28)
In an HCl medium (pH 1.5), ligustrazine (2,3,5,6-tetramethylpyrazine, TMP) reacted with 12-tungstophosphoric acid (TP) to form a 3 : 1 ion-association complex. As a result, the intensities of resonance Rayleigh scattering (RRS), second-order scattering (SOS) and frequency doubling scattering (FDS) were
Shankar Sachidhanandam et al.
Nature neuroscience, 16(11), 1671-1677 (2013-10-08)
Neocortical activity can evoke sensory percepts, but the cellular mechanisms remain poorly understood. We trained mice to detect single brief whisker stimuli and report perceived stimuli by licking to obtain a reward. Pharmacological inactivation and optogenetic stimulation demonstrated a causal
William McDonald et al.
Biochemistry, 53(27), 4467-4475 (2014-06-18)
Knowing how the protein environment modulates ligand pathways and redox centers in the respiratory heme-copper oxidases is fundamental for understanding the relationship between the structure and function of these enzymes. In this study, we investigated the reactions of O2 and
Rachael M Giersch et al.
Bio-protocol, 7(18) (2017-10-31)
Genome manipulation has become more accessible given the advent of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) editing technology. The Cas9 endonuclease binds a single stranded (single guide) RNA (sgRNA) fragment that recruits the complex to a corresponding genomic
Plasma concentrations of phenyllactic acid in phenylketonuria.
P C Clemens et al.
Journal of inherited metabolic disease, 13(2), 227-228 (1990-01-01)
Airi Sekine et al.
SpringerPlus, 4, 48-48 (2015-02-13)
The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor at endogenous brain concentrations. Recent studies have suggested that increase of brain KYNA levels is involved in psychiatric disorders such as schizophrenia and depression.
Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma.
Frederic J Kaye et al.
Journal of the National Cancer Institute, 107(1), 378-378 (2014-12-06)
S Ishiwata et al.
The Tohoku journal of experimental medicine, 176(1), 61-68 (1995-05-01)
To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mouse IgG and 3,3',5,5'-tetramethylbenzidine (TMBZ) were used as a secondary antibody and a substrate, respectively. The
BRAF V600E mutation identifies a subset of low-grade diffusely infiltrating gliomas in adults.
Andrew S Chi et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(14), e233-e236 (2013-04-03)
L H Elvers et al.
Journal of inherited metabolic disease, 30(4), 609-609 (2007-06-19)
Neonatal screening for congenital disorders like phenylketonuria (PKU), congenital hypothyroidism (CH) and congenital adrenal hyperplasia (CAH) is generally performed in dried blood spots on filter paper. The analytes of interest for testing for PKU, CH and CAH are phenylalanine, thyrotropin
Mark G Jones et al.
Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)
Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is
T De Smedt et al.
Toxicology letters, 231(3), 344-351 (2014-09-17)
On Saturday May 4, 2013, a train transporting chemicals derailed in the village of Wetteren (Belgium) and caused a leak of acrylonitrile (ACN). To assess the human exposure to acrylonitrile in the local population with the highest suspected exposure. Between
Zhe Yang et al.
Cell research, 28(10), 1013-1025 (2018-09-14)
Adequate protein intake is crucial for the survival and well-being of animals. How animals assess prospective protein sources and ensure dietary amino acid intake plays a critical role in protein homeostasis. By using a quantitative feeding assay, we show that
K J Bär et al.
Neurobiology of aging, 24(2), 333-338 (2002-12-25)
Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of
Nebivolol and valsartan: useful treatment for hypertension?
Bernard Waeber et al.
Lancet (London, England), 383(9932), 1864-1866 (2014-06-03)
Xin Zhang et al.
Hypertension (Dallas, Tex. : 1979), 64(1), 87-93 (2014-04-23)
Renovascular hypertension alters cardiac structure and function. Autophagy is activated during left ventricular hypertrophy and linked to adverse cardiac function. The angiotensin II receptor blocker, valsartan, lowers blood pressure and is cardioprotective, but whether it modulates autophagy in the myocardium
Mattia Quattrocelli et al.
JCI insight, 4(24) (2019-12-20)
In humans, chronic glucocorticoid use is associated with side effects like muscle wasting, obesity, and metabolic syndrome. Intermittent steroid dosing has been proposed in Duchenne Muscular Dystrophy patients to mitigate the side effects seen with daily steroid intake. We evaluated
Mary J Burton et al.
The American journal of the medical sciences, 348(6), 455-459 (2014-08-28)
We performed a pilot study examining the safety and tolerability of valacyclovir in veterans with herpes simplex virus type 2 and hepatitis C virus (HCV) coinfection. We performed a randomized double-blind, placebo-controlled, crossover clinical trial in U.S. veterans with genotype
M J McKinley
American journal of physiology. Regulatory, integrative and comparative physiology, 304(12), R1149-R1160 (2013-04-19)
Most ingested sodium is contained in food. The aim was to investigate whether sodium depletion, dehydration, or DOCA alters intakes of salted and unsalted foods by rats given choices of two foods: salted (0.2-0.5% Na) and unsalted food containing either
Byoung-Mo Koo et al.
Cell systems, 4(3), 291-305 (2017-02-13)
A systems-level understanding of Gram-positive bacteria is important from both an environmental and health perspective and is most easily obtained when high-quality, validated genomic resources are available. To this end, we constructed two ordered, barcoded, erythromycin-resistance- and kanamycin-resistance-marked single-gene deletion libraries
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