• 主页
  • 查找结果
  • A baculovirus dual expression system-based vaccine confers complete protection against lethal challenge with H9N2 avian influenza virus in mice.

A baculovirus dual expression system-based vaccine confers complete protection against lethal challenge with H9N2 avian influenza virus in mice.

Virology journal (2011-06-07)
Wenyao Lin, Huiying Fan, Xiaoliang Cheng, Yu Ye, Xiaowei Chen, Tao Ren, Wenbao Qi, Ming Liao
摘要

Avian influenza viruses of H9N2 subtype have become highly prevalent in avian species. Although these viruses generally cause only mild to moderate disease, they can infect a wide variety of species, including chickens, quail, turkeys, ducks, geese, pheasant, partridge, and pigeon, even transmitted to mammalian species, including humans, accelerating the efforts to devise protective strategies against them. The results showed that stronger immune responses were induced in a mouse model immunized with BV-Dual-HA than in those vaccinated with a DNA vaccine encoding the same antigen. Moreover, complete protection against lethal challenge with H9N2 virus was observed in mice. BV-Dual-HA could be utilized as a vaccine candidate against H9N2 virus infection.

材料
货号
品牌
产品描述

Sigma-Aldrich
金, nanopowder, <100 nm particle size, 99.9% trace metals basis