• 主页
  • 查找结果
  • Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model.

Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model.

Journal of virology (2013-01-25)
Helen E Farrell, Alexander M Abraham, Rhonda D Cardin, Ann-Sofie Mølleskov-Jensen, Mette M Rosenkilde, Nicholas Davis-Poynter
摘要

The mouse cytomegalovirus chemokine receptor homologue (CKR) M33 is required for salivary gland tropism and efficient reactivation from latency, phenotypes partially rescued by the human cytomegalovirus CKR US28. Herein, we demonstrate that complementation of salivary gland tropism is mediated predominantly by G protein-dependent signaling conserved with that of M33; in contrast, both G protein-dependent and -independent pathways contribute to the latency phenotypes. A novel M33-dependent replication phenotype in cultured bone marrow macrophages is also described.

材料
货号
品牌
产品描述

Sigma-Aldrich
Triton X-100, laboratory grade
Sigma-Aldrich
Triton X-100, for molecular biology
Sigma-Aldrich
Triton X-100, BioXtra
Sigma-Aldrich
Triton X-100 溶液, BioUltra, for molecular biology, ~10% in H2O
Sigma-Aldrich
Triton X-45
Sigma-Aldrich
Triton X-102
Sigma-Aldrich
Triton X-305 溶液, 70% in H2O
Sigma-Aldrich
Triton X-100, peroxide- and carbonyl-free
聚乙二醇单辛基苯基醚, European Pharmacopoeia (EP) Reference Standard