• 主页
  • 查找结果
  • Cobryketone derived from vitamin B12 via palladium-catalyzed cleavage of the sp3-sp3 carbon-carbon bond.

Cobryketone derived from vitamin B12 via palladium-catalyzed cleavage of the sp3-sp3 carbon-carbon bond.

The Journal of organic chemistry (2013-04-03)
Sylwester Kurcoń, Keith ó Proinsias, Dorota Gryko
摘要

Heptamethyl cobyrinate was transformed into hexamethyl 8-nor-cobyrinate. The crucial step involved the synthesis of new, vitamin B12 derived cobryketone via palladium-catalyzed cleavage of the sp(3)-sp(3) carbon-carbon bond with the liberation of the ketone. The replacement of sp(3) carbon atom with sp(2) (C═O) at the 8-position produces a bathochromic shift of all absorption bands and makes α and β bands equal as a consequence of the expansion of the existing conjugated system of double bonds.

材料
货号
品牌
产品描述

Sigma-Aldrich
维生素 B 12, ≥98%
Supelco
维生素B12, pharmaceutical secondary standard, certified reference material
Sigma-Aldrich
维生素 B 12, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%
Supelco
腈钴胺(维生素 B12), analytical standard
Sigma-Aldrich
氰钴胺, meets USP testing specifications
Supelco
维生素B12标准液 CRM 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Sigma-Aldrich
钯, powder, <1 μm, ≥99.9% trace metals basis
Sigma-Aldrich
钯, powder, 99.995% trace metals basis
Sigma-Aldrich
钯黑, surface area 40-60 m2/g, 99.95% trace metals basis
Sigma-Aldrich
氰钴胺, tested according to Ph. Eur.
Sigma-Aldrich
钯, wire, diam. 1.0 mm, 99.9% trace metals basis
Sigma-Aldrich
钯, granular, 99.99% trace metals basis
Sigma-Aldrich
钯, wire, diam. 0.5 mm, 99.9% trace metals basis
Sigma-Aldrich
钯, foil, thickness 0.025 mm, 99.9% trace metals basis
Sigma-Aldrich
钯, sponge, 99.9% trace metals basis
Sigma-Aldrich
钯, foil, thickness 0.05 mm, 99.9% trace metals basis
Sigma-Aldrich
钯, nanopowder, <25 nm particle size (TEM), ≥99.5%
Sigma-Aldrich
钯, rod, diam. 6.25 mm, ≥99.9% trace metals basis
Sigma-Aldrich
钯, foil, thickness 0.5 mm, 99.9% trace metals basis
Sigma-Aldrich
钯, powder, <75 μm, 99.9% trace metals basis
Sigma-Aldrich
钯, foil, thickness 0.25 mm, 99.98% trace metals basis
Sigma-Aldrich
钯, foil, thickness 1.0 mm, 99.9% trace metals basis
Sigma-Aldrich
钯, evaporation slug, diam. × L 0.6 cm × 0.6 cm, 99.95% trace metals basis