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[Ionic conjugates of sulfate carboxymethyl cellulose with dialkylaminomethyl derivatives of 2-isobornyl-4-methylphenol: synthesis and study of anti-inflammatory and analgesic activity].

Bioorganicheskaia khimiia (2013-04-04)
I Iu Chukicheva, E V Buravlev, M A Torlopov, Iu B Vikharev, L V Anikina, V V Grishko
ABSTRACT

Water-soluble sulfate polysalts of carboxymethyl cellulose and tertiary aminomethyl derivatives of 2-isobornyl-4-methylphenol was obtained. For the synthesized conjugates investigated in vivo anti-inflammatory activity in the test of acute formalin inflammation and analgesic activity in tests the "hot plate" and "vinegar cramps".

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
甲醛 溶液, ACS reagent, 37 wt. % in H2O, contains 10-15% Methanol as stabilizer (to prevent polymerization)
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SAFC
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Supelco
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羧甲基纤维素钠, average Mw ~250,000, degree of substitution 1.2
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甲醛 溶液, tested according to Ph. Eur.
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羧甲基纤维素 钠盐, ultra high viscosity, highly purified