• 主页
  • 查找结果
  • Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease.

Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease.

Biological psychiatry (1999-09-24)
M A Raskind, E R Peskind, C Holmes, D S Goldstein
摘要

High cerebrospinal fluid (CSF) norepinephrine (NE) concentrations in aging and Alzheimer's disease (AD) could reflect decreased NE clearance from central nervous system (CNS) extracellular fluid or increased release of NE into CNS extracellular fluid. Measuring CSF concentrations of the intraneuronal NE metabolite dihydroxyphenylglycol (DHPG), an estimate of NE clearance, and the NE precursor dihydroxyphenylacetic acid (DOPA), an estimate of NE biosynthesis, can help differentiate these mechanisms. NE, DHPG, and DOPA were determined by HPLC in CSF and plasma obtained following yohimbine, clonidine, and placebo. Ten AD, 10 older, and 11 young subjects were studied. CSF DOPA following yohimbine was higher in older and AD than in young subjects. CSF DHPG did not differ among groups. Plasma DOPA following yohimbine was higher in AD than in young subjects. During alpha-2 adrenoreceptor blockade in both aging and AD, there are increased responses of CNS NE biosynthesis and release with unchanged CNS NE clearance. This pattern is consistent with partial loss of CNS noradrenergic neurons with compensatory activation of remaining CNS noradrenergic neurons. Given the marked loss of locus coeruleus (LC) noradrenergic neurons in AD, achievement of high CSF NE suggests particularly prominent compensatory activation of remaining LC neurons in this disorder.

材料
货号
品牌
产品描述

Sigma-Aldrich
L -谷氨酰胺 溶液, 200 mM, solution, sterile-filtered, BioXtra, suitable for cell culture
Sigma-Aldrich
甘氨酸, suitable for electrophoresis, ≥99%
Sigma-Aldrich
甘氨酸, ReagentPlus®, ≥99% (HPLC)
Sigma-Aldrich
D -山梨醇, ≥98%
Sigma-Aldrich
D -甘露醇, ≥98%
Sigma-Aldrich
L-谷氨酰胺, meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source
Sigma-Aldrich
L-谷氨酸, ReagentPlus®, ≥99% (HPLC)
Sigma-Aldrich
L -赖氨酸, ≥98% (TLC)
Sigma-Aldrich
L-脯氨酸, ReagentPlus®, ≥99% (HPLC)
Sigma-Aldrich
左旋多巴, ≥98% (TLC)
Sigma-Aldrich
肌醇 -肌醇, ≥99%
Sigma-Aldrich
甘氨酸, BioUltra, for molecular biology, ≥99.0% (NT)
Sigma-Aldrich
γ-氨基丁酸, ≥99%
SAFC
L-谷氨酰胺溶液 200mM, 29.23 mg/mL in saline, solution, suitable for cell culture
Sigma-Aldrich
L-亮氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-脯氨酸, from non-animal source, meets EP, USP testing specifications, suitable for cell culture
Sigma-Aldrich
L-酪氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-异亮氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
锌, dust, <10 μm, ≥98%
Sigma-Aldrich
L-谷氨酰胺, ReagentPlus®, ≥99% (HPLC)
Sigma-Aldrich
L-异亮氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Sigma-Aldrich
肌醇 -肌醇, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture
Sigma-Aldrich
反丁烯二酸, ≥99.0% (T)
Sigma-Aldrich
L-天冬氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-苯基丙氨酸, reagent grade, ≥98%
Sigma-Aldrich
镁, turnings, reagent grade, 98%
Sigma-Aldrich
甘氨酸, ACS reagent, ≥98.5%
Sigma-Aldrich
锌, granular, 20-30 mesh, ACS reagent, ≥99.8%
Sigma-Aldrich
L -缬氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-丝氨酸, ReagentPlus®, ≥99% (HPLC)