• 主页
  • 查找结果
  • Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease.

Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease.

Neurochemical research (2003-07-02)
S Engelborghs, B Marescau, P P De Deyn
摘要

To study changes in amino acid metabolism and biogenic amines in Parkinson's disease, we set up a prospective study and measured biogenic amines, their main metabolites, and 22 different amino acids, in cerebrospinal fluid of Parkinson's disease patients (n = 24) and age-matched controls (n = 30). A trend toward higher dopamine levels in Parkinson's disease patients was interpreted as an effect of treatment with levodopa and/or selegiline. Significantly lower concentrations of the dopamine metabolite 3,4-dihydroxyphenylacetic acid in the Parkinson's disease group might reflect dopaminergic cell loss. Our results revealed decreased serotonin catabolism that was interpreted as an effect of treatment with selegiline. Whereas all amino acid levels were unchanged, taurine was significantly lower in Parkinson's disease patients. Studies showed that taurine exerts a trophic action on the central nervous system. In this view, decreased taurine in a neurodegenerative disorder as Parkinson's disease deserves attention.

材料
货号
品牌
产品描述

Sigma-Aldrich
甘氨酸, suitable for electrophoresis, ≥99%
Sigma-Aldrich
甘氨酸, ReagentPlus®, ≥99% (HPLC)
Sigma-Aldrich
乙醇胺, ≥98%
Sigma-Aldrich
L -赖氨酸, ≥98% (TLC)
Sigma-Aldrich
牛磺酸, ≥99%
Sigma-Aldrich
甘氨酸, BioUltra, for molecular biology, ≥99.0% (NT)
Sigma-Aldrich
L-甲硫氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-酪氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-异亮氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
锌, dust, <10 μm, ≥98%
Sigma-Aldrich
乙醇胺, ACS reagent, ≥99.0%
Sigma-Aldrich
L-异亮氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Sigma-Aldrich
L-天冬氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-苯基丙氨酸, reagent grade, ≥98%
Sigma-Aldrich
镁, turnings, reagent grade, 98%
Sigma-Aldrich
甘氨酸, ACS reagent, ≥98.5%
Sigma-Aldrich
锌, granular, 20-30 mesh, ACS reagent, ≥99.8%
Sigma-Aldrich
(-)-肾上腺素
Sigma-Aldrich
L-丝氨酸, ReagentPlus®, ≥99% (HPLC)
Sigma-Aldrich
L-甲硫氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0%
Sigma-Aldrich
甘氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, ≥98.5%
Sigma-Aldrich
锌, purum, powder
Sigma-Aldrich
锌, powder, <150 μm, 99.995% trace metals basis
SAFC
L-甲硫氨酸
Sigma-Aldrich
L-苯基丙氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Sigma-Aldrich
S-(5′-腺苷)-L-高半胱氨酸, crystalline
Sigma-Aldrich
L-瓜氨酸, ≥98% (TLC)
Sigma-Aldrich
乙醇胺, liquid, BioReagent, suitable for cell culture, ≥98%
Sigma-Aldrich
铜, powder, <425 μm, 99.5% trace metals basis
Sigma-Aldrich
L -胱氨酸, ≥98% (TLC), crystalline