Merck

The human cerebrospinal fluid metabolome.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2008-05-27)
David S Wishart, Michael J Lewis, Joshua A Morrissey, Mitchel D Flegel, Kevin Jeroncic, Yeping Xiong, Dean Cheng, Roman Eisner, Bijaya Gautam, Dan Tzur, Summit Sawhney, Fiona Bamforth, Russ Greiner, Liang Li
摘要

With continuing improvements in analytical technology and an increased interest in comprehensive metabolic profiling of biofluids and tissues, there is a growing need to develop comprehensive reference resources for certain clinically important biofluids, such as blood, urine and cerebrospinal fluid (CSF). As part of our effort to systematically characterize the human metabolome we have chosen to characterize CSF as the first biofluid to be intensively scrutinized. In doing so, we combined comprehensive NMR, gas chromatography-mass spectrometry (GC-MS) and liquid chromatography (LC) Fourier transform-mass spectrometry (FTMS) methods with computer-aided literature mining to identify and quantify essentially all of the metabolites that can be commonly detected (with today's technology) in the human CSF metabolome. Tables containing the compounds, concentrations, spectra, protocols and links to disease associations that we have found for the human CSF metabolome are freely available at http://www.csfmetabolome.ca.

材料
货号
品牌
产品描述

Sigma-Aldrich
甲醇, suitable for HPLC, ≥99.9%
Sigma-Aldrich
丙酮, ACS reagent, ≥99.5%
Sigma-Aldrich
2-丙醇, BioReagent, for molecular biology, ≥99.5%
Sigma-Aldrich
2-丙醇, suitable for HPLC, 99.9%
Sigma-Aldrich
甘油, for molecular biology, ≥99.0%
Sigma-Aldrich
甲醇, anhydrous, 99.8%
Sigma-Aldrich
2-丙醇, ACS reagent, ≥99.5%
Sigma-Aldrich
乙酸, glacial, ReagentPlus®, ≥99%
Sigma-Aldrich
丙酮, suitable for HPLC, ≥99.9%
Sigma-Aldrich
甲醇, ACS reagent, ≥99.8%
Sigma-Aldrich
2-丙醇, anhydrous, 99.5%
Sigma-Aldrich
乙酸, glacial, ACS reagent, ≥99.7%
Sigma-Aldrich
L -谷氨酰胺 溶液, 200 mM, solution, sterile-filtered, BioXtra, suitable for cell culture
Sigma-Aldrich
甘油, ≥99.5%
Sigma-Aldrich
丙酮, HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%
Sigma-Aldrich
柠檬酸, ACS reagent, ≥99.5%
Sigma-Aldrich
甲酸, reagent grade, ≥95%
Sigma-Aldrich
尿素, powder, BioReagent, for molecular biology, suitable for cell culture
Sigma-Aldrich
甘油, ACS reagent, ≥99.5%
Sigma-Aldrich
甲醇, HPLC Plus, ≥99.9%
Sigma-Aldrich
甲醇, suitable for HPLC, gradient grade, ≥99.9%
Sigma-Aldrich
尿素, ACS reagent, 99.0-100.5%
Sigma-Aldrich
甘油, ReagentPlus®, ≥99.0% (GC)
Supelco
对乙酰氨基酚, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
D -甘露醇, ≥98%
Sigma-Aldrich
异丙醇, 70% in H2O
Sigma-Aldrich
L-谷氨酰胺, meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source
Sigma-Aldrich
柠檬酸, 99%
Sigma-Aldrich
甲酸, ACS reagent, ≥96%
Sigma-Aldrich
异丙醇, ≥99.7%, FCC, FG