Merck
  • Home
  • Search Results
  • Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis.

Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis.

Journal of neurology (1983-01-01)
D Rating, H Siemes, W Löscher
ABSTRACT

In 14 children with epilepsy, 51 with febrile convulsions and 22 with meningitis gamma-aminobutyric acid (GABA) concentrations in lumbar CSF were determined. While the mean for CSF GABA concentrations for all epileptic children was unchanged [144 (range: 73-285) pmol/ml; controls: 148 (range: 90-243) pmol/ml] extraordinarily high GABA levels were found in the CSF of two children on valproate (525 and 557 pmol/ml) and remarkably low GABA concentrations in hitherto untreated epileptic children [109 (range: 67-176) pmol/ml]. Children with febrile convulsions [103 (range: 63-170) pmol/ml] and acute meningitis [105 (range: 65-171) pmol/ml] had significantly decreased CSF GABA concentrations (P less than 0.001 and P less than 0.02 compared with controls). The data indicate that valproate intake increases dramatically the GABA concentrations in the CSF of epileptic children. Furthermore, the study supports the concept that low GABAergic activity within the CNS may be one cause for an increased seizure frequency.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
L -谷氨酰胺 溶液, 200 mM, solution, sterile-filtered, BioXtra, suitable for cell culture
Sigma-Aldrich
尿素, powder, BioReagent, for molecular biology, suitable for cell culture
Sigma-Aldrich
尿素, ACS reagent, 99.0-100.5%
Sigma-Aldrich
L-谷氨酰胺, meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source
SAFC
L-谷氨酰胺溶液 200mM, 29.23 mg/mL in saline, solution, suitable for cell culture
Sigma-Aldrich
L-谷氨酸, ReagentPlus®, ≥99% (HPLC)
Sigma-Aldrich
L-亮氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
牛磺酸, ≥99%
Sigma-Aldrich
L-甲硫氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
尿素, ReagentPlus®, ≥99.5%, pellets
Sigma-Aldrich
L -异亮氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
丙酮酸, 98%
Sigma-Aldrich
L-甲硫氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0%
Sigma-Aldrich
L-酪氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-苯基丙氨酸, reagent grade, ≥98%
Sigma-Aldrich
L-谷氨酰胺, ReagentPlus®, ≥99% (HPLC)
Sigma-Aldrich
L-天冬氨酸, reagent grade, ≥98% (HPLC)
Supelco
尿素, 8 M (after reconstitution with 16 mL high purity water)
Sigma-Aldrich
γ-氨基丁酸, ≥99%
Sigma-Aldrich
L -缬氨酸, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-天冬酰胺, ≥98% (HPLC)
Sigma-Aldrich
L-亮氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Sigma-Aldrich
L -异亮氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Sigma-Aldrich
L-丙氨酸, ≥98% (TLC)
Sigma-Aldrich
尿素, BioXtra, pH 7.5-9.5 (20 °C, 5 M in H2O)
SAFC
L-甲硫氨酸
Sigma-Aldrich
L-苏氨酸, reagent grade, ≥98% (HPLC)
SAFC
L-谷氨酰胺
Sigma-Aldrich
尿素 溶液, BioUltra, ~8 M in H2O
Sigma-Aldrich
L-苯基丙氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%