Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Journal of inorganic biochemistry (2011-11-22)

Maire E Percy, Theo P A Kruck, Aileen I Pogue, Walter J Lukiw

PMID22099160

摘要

In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this treatment worked still is not clear. In this critical interdisciplinary review, we provide an overview of the complexities of AD and involvement of metal ions, and revisit the neglected DFO trial. We discuss research done by us and others that is helping to explain involvement of metal ion catalyzed production of reactive oxygen species in the pathogenesis of AD, and emerging strategies for inhibition of metal-ion toxicity. Highlighted are insights to be considered in the quests to prevent potentially toxic effects of aluminum toxicity and prevention and intervention in AD.

材料

货号

品牌

产品描述

11009

Sigma-Aldrich

铝, powder, ≥91% (complexometric)

518573

Sigma-Aldrich

铝, granular, <1 mm, 99.7% trace metals basis

266558

Sigma-Aldrich

铝, wire, diam. 1.0 mm, 99.999% trace metals basis

326852

Sigma-Aldrich

铝, foil, thickness 0.25 mm, 99.999% trace metals basis

266523

Sigma-Aldrich

铝, ReagentPlus^®, beads, 5-15 mm, 99.9% trace metals basis

266574

Sigma-Aldrich

铝, foil, thickness 0.45-0.55 mm, 99.999% trace metals basis

310360

Sigma-Aldrich

铝, ACS reagent, 99%, wire, wire diam. ~1.5 mm

326860

Sigma-Aldrich

铝, foil, thickness 0.13 mm, ≥99.99% trace metals basis

338788

Sigma-Aldrich

铝, pellets, 3-12 mm, 99.99% trace metals basis

326887

Sigma-Aldrich

铝, wire, diam. 0.58 mm, ≥99.99% trace metals basis

326941

Sigma-Aldrich

铝, pellets, 3-8 mesh, ≥99.999% trace metals basis

GF24569602

铝, foam, 150x150mm, thickness 30mm, bulk density 0.2g/cm³, porosity 0.93, aluminum 6101 grade, 98.5%

266957

Sigma-Aldrich

铝, foil, thickness 1.0 mm, 99.999% trace metals basis

GF44675781

铝, rod, 1000mm, diameter 12.7mm, 99%

GF98718935

铝, sphere, 100pcs, diameter 1.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

433705

Sigma-Aldrich

铝, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis

GF26812043

铝, foam, 150x150mm, thickness 3.2mm, bulk density 0.2g/cm³, porosity 0.93, 16 pores/cm, aluminum 6101 grade, 98.5%

GF63629219

铝, tube, 500mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%

GF51598761

铝, rod, 200mm, diameter 12.7mm, 99%

GF94706354

铝, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF95825403

铝, sphere, 100pcs, diameter 3.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

GF29732496

铝, tube, 200mm, outside diameter 3.0mm, inside diameter 1.62mm, wall thickness 0.69mm, hard, 99.5%

GF64700524

铝, rod, 1000mm, diameter 5.0mm, as drawn, 99.999%

GF32029444

铝, rod, 100mm, diameter 12.7mm, 99%

GF31003456

铝, rod, 100mm, diameter 5.0mm, as drawn, 99.999%

GF72634103

铝, rod, 50mm, diameter 28mm, as drawn, 99.999%

GF51278070

铝, honeycomb, 300x300mm, thickness 10mm, cell size 3.2mm, cell wall 0.025mm, core density 0g/cm³, phenolic adhesive (resin), 99.5%

GF02417677

铝, tube, 100mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%

GF72281088

铝, wire reel, 20m, diameter 0.7mm, as drawn, 99.5%

GF93280732

铝, rod, 500mm, diameter 15.0mm, as drawn, 99.999%