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  • Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Journal of inorganic biochemistry (2011-11-22)
Maire E Percy, Theo P A Kruck, Aileen I Pogue, Walter J Lukiw
摘要

In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this treatment worked still is not clear. In this critical interdisciplinary review, we provide an overview of the complexities of AD and involvement of metal ions, and revisit the neglected DFO trial. We discuss research done by us and others that is helping to explain involvement of metal ion catalyzed production of reactive oxygen species in the pathogenesis of AD, and emerging strategies for inhibition of metal-ion toxicity. Highlighted are insights to be considered in the quests to prevent potentially toxic effects of aluminum toxicity and prevention and intervention in AD.

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Sigma-Aldrich
铝, foil, thickness 0.45-0.55 mm, 99.999% trace metals basis
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铝, granular, <1 mm, 99.7% trace metals basis
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铝, wire, diam. 1.0 mm, 99.999% trace metals basis
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铝, ReagentPlus®, beads, 5-15 mm, 99.9% trace metals basis
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铝, foil, thickness 0.25 mm, 99.999% trace metals basis
Sigma-Aldrich
铝, pellets, 3-12 mm, 99.99% trace metals basis
Sigma-Aldrich
铝, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis
Sigma-Aldrich
铝, wire, diam. 0.58 mm, ≥99.99% trace metals basis
Sigma-Aldrich
铝, ≤30 μm, spherical powder, ≥99%
Sigma-Aldrich
铝, foil, thickness 0.13 mm, ≥99.99% trace metals basis
Sigma-Aldrich
铝, pellets, 3-8 mesh, ≥99.999% trace metals basis
Sigma-Aldrich
铝, ACS reagent, 99%, wire, wire diam. ~1.5 mm
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铝, rod, diam. × L 3.0 mm × 100 mm, 99.999% trace metals basis
铝, IRMM®, certified reference material, 0.1 mm foil
铝, wire reel, 25m, diameter 0.25mm, as drawn, 99.5%
铝, wire reel, 10m, diameter 0.025mm, as drawn, 99.0+%
铝, honeycomb, 300x300mm, thickness 5mm, cell size 3.2mm, cell wall 0.025mm, core density 0.072g/cm3, phenolic adhesive (resin), 99.5%
铝, wire reel, 500m, diameter 0.5mm, as drawn, 99.5%
铝, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh
铝, foam, 150x150mm, thickness 10mm, bulk density 0.2g/cm3, porosity 0.93, aluminum 6101 grade, 98.5%
铝, foam, 150x150mm, thickness 3.2mm, bulk density 0.2g/cm3, porosity 0.93, 16 pores/cm, aluminum 6101 grade, 98.5%
铝, foam, 150x150mm, thickness 30mm, bulk density 0.2g/cm3, porosity 0.93, aluminum 6101 grade, 98.5%
铝, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 16 pores/cm, aluminum 6101 grade, 98.5%
铝, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 2 pores/cm, aluminum 6101 grade, 98.5%
铝, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 4 pores/cm, aluminum 6101 grade, 98.5%
铝, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 8 pores/cm, aluminum 6101 grade, 98.5%
铝, foam, 300x400mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, aluminum 6101 grade, 98.5%
铝, foam, 33x140mm, thickness 20mm, bulk density 0.2g/cm3, porosity 0.93, aluminum 6101 grade, 98.5%
铝, honeycomb, 150x150mm, thickness 10mm, cell size 3.2mm, cell wall 0.025mm, core density 0g/cm3, phenolic adhesive (resin), 99.5%
铝, honeycomb, 150x150mm, thickness 52.3mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm3, phenolic adhesive (resin), facing skin aluminum 0.55mm, 99.9%

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