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  • Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)
A G Quiroga
摘要

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

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铂, wire, diam. 0.5 mm, 99.99% trace metals basis
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铂, foil, thickness 0.025 mm, 99.9% trace metals basis
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铂, wire, diam. 0.25 mm, 99.9% trace metals basis
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铂, wire, diam. 0.5 mm, 99.9% trace metals basis
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铂, gauze, 100 mesh, 99.9% trace metals basis
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铂黑, black, powder, ≤20 μm, ≥99.95% trace metals basis
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铂, wire, diam. 1.0 mm, 99.9% trace metals basis
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铂, foil, thickness 0.05 mm, 99.99% trace metals basis
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铂, powder, 99.995% trace metals basis
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铂, gauze, 52 mesh, 99.9% trace metals basis
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铂, nanopowder, <50 nm particle size (TEM)
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铂, wire, diam. 2.0 mm, 99.9% trace metals basis
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铂, wire, diam. 0.10 mm, 99.99% trace metals basis
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铂, powder, ≤10 μm, 99.9% trace metals basis
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铂, wire, diam. 0.25 mm, 99.99% trace metals basis
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铂黑, fuel cell grade, ≥99.9% trace metals basis
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铂, wire, diam. 0.076 mm, ≥99.99% trace metals basis
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铂, foil, thickness 0.125-0.135 mm, 99.9% trace metals basis
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铂, foil, thickness 1.0 mm, 99.99% trace metals basis
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铂, foil, thickness 0.25 mm, 99.99% trace metals basis
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铂, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)
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铂, wire, diam. 0.25 mm, thermocouple grade
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铂, wire, diam. 0.127 mm, 99.99% trace metals basis
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铂, wire, diam. 1.0 mm, 99.99% trace metals basis
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铂, wire, diam. 0.20 mm, ≥99.99% trace metals basis
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铂, wire, diam. 0.127 mm, 99.9% trace metals basis
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铂, powder (coarse), 99.99% trace metals basis
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铂黑, low bulk density, ≥99.9% trace metals basis
铂, wire reel, 0.1m, diameter 1.0mm, annealed, may be used as one component of a thermocouple, 99.99%
铂, wire reel, 1m, diameter 0.3mm, annealed, may be used as one component of a thermocouple, 99.99%

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